Taw qhia

Ursodeoxycholic Acid (UDCA), tseem hu ua ursodiol, yog ib qho tshwm sim ntawm cov kua tsib nyob rau hauv cov kua tsib me me hauv tib neeg cov kua tsib. Nws yog tib yam tshuaj uas tsim los rau kev kho mob cholestatic daim siab kab mob- tej yam kev mob uas cov kua tsib ntws tsis zoo, ua rau cov kua tsib kua qaub uas muaj kuab lom thiab ua rau lub siab puas tsuaj.^[1].

Dab tsi ua rau UDCA tshwj xeeb yog nws cov txheej txheem ntau lub hom phiaj. Tsis zoo li cov tshuaj uas tsuas yog tswj cov tsos mob xwb, UDCA hauv paus hloov cov kab mob ntawm koj cov kua tsib- ua rau nws tsis tshua muaj peev xwm tsim cov cholesterol gallstones-thaum ib txhij tiv thaiv koj lub siab hlwb los ntawm cov kua tsib acid-induced raug mob. Nws ua qhov no los ntawm kev txhim kho cov kua tsib kua qaub, txo oxidative kev nyuaj siab, tiv thaiv cell tuag (apoptosis), thiab calming o.^[2].

Niaj hnub no, UDCA yog tsim los ntawm kev siv tshuaj lom neeg zoo dua li ntawm cov kab mob dais, muab kev coj ncaj ncees, zoo ib yam, thiab siab dawb huv rau kev siv tshuaj thiab nutraceutical thoob ntiaj teb. Nws tau txais dav raws li thawj kab qauv ntawm kev saib xyuas rau thawj tus kab mob biliary cholangitis (PBC) thiab cholesterol gallstone dissolution.^[4], thiab tau txais kev lees paub ntau ntxiv rau nws lub luag haujlwm hepatoprotective hauv tshuaj tiv thaiv lub siab raug mob (DILI)^[2]intrahepatic cholestasis ntawm cev xeeb tub (ICP)^[5], thiab ntau yam kab mob siab^[1].

Physicochemical Properties & Specifications

Khoom	Tus nqi
CAS Nr	128-13-2
Molecular Formula	C₂₄H₄₀O₄
Molecular Luj	392.58 g / mol
Qhov tshwm sim	Dawb rau tawm -dawb crystalline hmoov
Melting Point	200-204℃(decomposes)
Specific Optical Rotation	+59.0℃rau +62.0℃(c=1 hauv ethanol)
Purity	Ntau dua los yog sib npaug rau 99.0% (HPLC, USP / EP, ntawm lub hauv paus qhuav)
Poob rau ziab	Tsawg dua lossis sib npaug li 1.0%
Residue ntawm Ignition	Tsawg dua lossis sib npaug li 0.1%
Hnyav Hlau	Tsawg dua lossis sib npaug li 10 ppm
Lead (Pb)	Tsawg dua lossis sib npaug li 1 ppm
Yam khoom (tag nrho impurities)	Tsawg dua lossis sib npaug li 1.0%
Cholic Acid impurity	Tsawg dua los yog sib npaug li 0.5%
Deoxycholic Acid impurity	Tsawg dua los yog sib npaug li 0.5%
Solubility hauv dej	Xyaum insoluble
Solubility hauv Ethanol	Dawb soluble
Solubility hauv Chloroform	Soluble
Solubility hauv DMSO	Soluble (~ 30 mg/mL)
pH (1% tshem tawm)	6.5–8.0
Microbiological txwv	USP<61>ua raws
Kev cia khoom	Ntim ntim, 2-8 degree, tiv thaiv los ntawm lub teeb thiab noo noo
Txee lub neej	36–48 lub hlis

Mechanism ntawm Action

Xav txog UDCA li koj lub siab"Shock absorber thiab kho neeg coob"ua ke rau hauv ib lub molecule. Nov yog nws ua haujlwm li cas:

Kauj Ruam 1 - UDCA hloov koj cov kua tsib muaj pes tsawg leeg (kev tiv thaiv gallstone).
Koj lub siab tsim cov kua tsib kom zom cov rog. Thaum muaj cov roj (cholesterol) ntau dhau los ntawm cov kua tsib acids, cov roj (cholesterol) tuaj yeem ua crystallize thiab tsim cov gallstones. UDCA txo cov roj (cholesterol) tso rau hauv cov kua tsib thiab ua kom cov kua qaub tiv thaiv, ua rau koj cov kua tsib tsawg "pob zeb tsim." Sij hawm dhau mus, qhov no tuaj yeem pab yaj cov roj cholesterol uas twb muaj lawm thiab tiv thaiv cov tshiab los ntawm kev tsim^[1].

Kauj Ruam 2 - UDCA tiv thaiv koj lub siab hlwb (cytoprotection).
Hauv cov kab mob cholestatic daim siab, cov kua tsib kua qaub tsim tawm hauv cov hlwb thiab ua zoo li "dawb huv," ua rau mitochondria ua rau lub cev tuag. UDCA txhim kho kev thauj mus los ntawm cov kua tsib kua qaub tawm ntawm cov hlwb, txo cov kev ntxhov siab oxidative, thiab tiv thaiv apoptosis (programmed cell tuag) [2]. Nws kuj stabilizes cell membranes thiab muaj antioxidant zog^[1].

Kauj Ruam 3 - UDCA calms o thiab txhawb kev tiv thaiv kab mob.
UDCA muaj cov teebmeem immunomodulatory-nws pab txo cov kab mob inflammatory uas ua rau lub siab puas tsuaj rau cov kab mob autoimmune daim siab zoo li PBC^[2][4].

Nyob rau hauv ib tug nutshell,UDCA ua haujlwm ntawm peb lub ntsej muag ib txhij: tiv thaiv kab mob gallstones los ntawm kev txo cov roj cholesterol, tiv thaiv lub siab ntawm cov kua tsib kua qaub, thiab txo qhov mob. Qhov kev txiav txim triple no ua rau nws muaj ntau yam thiab muaj kev nyab xeeb hepatoprotective tus neeg sawv cev^[1][2].

Cov txiaj ntsig kev noj qab haus huv

1. First-Line Treatment for Primary Biliary Cholangitis (PBC)
UDCA yog tus qauv thawj kab kev kho mob rau PBC, kab mob siab autoimmune uas tuaj yeem ua rau mob cirrhosis^[4]. Ntawm cov koob tshuaj pom zoo ntawm 13–15 mg / kg / hnub, UDCA txhim kho daim siab biochemical cim cim thiab cuam tshuam nrog kev muaj sia nyob thiab kev xav tau qeeb rau kev hloov pauv daim siab.^[1]. Txog 60–70% ntawm cov neeg mob teb txaus rau UDCA ib leeg; Cov tsis teb yuav yog cov neeg sib tw rau kev kho mob thib ob xws li PPAR agonists^[4].

2. Txo cov roj (cholesterol) hauv cov pob zeb
UDCA tsuas yog FDA pom zoo tshuaj rau kev tshem tawm cov roj cholesterol hauv cov pob zeb hauv cov neeg mob uas tsis yog cov neeg sib tw rau kev phais. Nws ua haujlwm los ntawm kev txo cov roj cholesterol saturation ntawm cov kua tsib, maj mam yaj cov pob zeb dhau 6-12 lub hlis [1]. A 2025 meta-analysis tau lees paub tias UDCA txo qhov kev pheej hmoo ntawm cholecystectomy rau cov tsos mob pob zeb^[4].

3. Txhawb nqa rov qab los ntawm Tshuaj Txhaum Mob Siab (DILI)
UDCA tau raug siv los txhawb lub siab rov qab los ntawm kev siv tshuaj tiv thaiv lub siab, tshwj xeeb yog cholestatic DILI. Cov kev tshawb fawb soj ntsuam ua ntej kuj tau pom muaj txiaj ntsig zoo hauv hepatocellular DILI, uas qhia txog UDCA cov khoom siv dav dav hauv hepatoprotective, suav nrog cov tshuaj tiv thaiv kab mob, tshuaj tua kab mob, tshuaj tiv thaiv kab mob, thiab tshuaj tiv thaiv apoptotic.^[2].

4. Tswj Intrahepatic Cholestasis of Pregnancy (ICP)
UDCA yog thawj kws kho mob rau ICP, lub siab tsis zoo ntawm cev xeeb tub uas ua rau khaus hnyav thiab ua rau muaj kev pheej hmoo ntawm fetus.^[5]. Meta-analyses tau pom tias UDCA txo qhov mob pruritus, txhim kho lub siab ua haujlwm, thiab txo qis tus me nyuam yug ntxov thiab kev ntxhov siab hauv plab.^[5].

5. Cov txiaj ntsig zoo rau Cardiometabolic Health
Ib xyoo 2025 kev tshuaj xyuas thiab kev tshuaj xyuas meta-analyses ntawm 12 RCTs pom tias UDCA supplementation ua tau zoo tuaj yeem txhim kho lub cev qhov hnyav (BMI) thiab diastolic ntshav siab.^[3]. Txawm hais tias ua ntej, cov kev tshawb pom no qhia tias muaj peev xwm siv tau rau UDCA hauv kev noj qab haus huv metabolic dhau lub siab.

Daim ntawv thov

1. Pharmaceutical API

Primary biliary cholangitis (PBC) - thawj kab kev kho mob ntawm 13–15 mg / kg / hnub [1][4]

Cov roj cholesterol dissolution ntawm gallstones (radiolucent, non-calcified pob zeb<20 mm diameter) [1]

Intrahepatic cholestasis ntawm cev xeeb tub (ICP) [5]

Drug-induced siab raug mob (DILI), tshwj xeeb tshaj yog hom cholestatic [2]

Cystic fibrosis-uas cuam tshuam rau daim siab kab mob, pediatric cholestatic mob

2. Nutraceuticals & Cov Khoom Siv Kho Mob Siab
UDCA tau siv ntau ntxiv hauv cov khoom noj khoom haus tsom rau lub siab noj qab haus huv, detoxification, thiab metabolic noj qab haus huv. Muaj nyob rau hauv cov ntsiav tshuaj, ntsiav tshuaj, thiab hmoov sib tov.

3. Tsiaj Kev Noj Qab Haus Huv & Veterinary Tshuaj
Siv rau hauv dev, miv, thiab tsiaj nyeg rau kab mob siab cholestatic, hepatotoxicity, thiab kev txhawb nqa metabolic. Pub-qib UDCA yog tsim los rau hauv cov khoom noj khoom haus tsiaj rau kev kho mob thiab kev siv tshuaj tiv thaiv.

4. Kev Tshawb Fawb & Kev Txhim Kho
High-purity UDCA yog siv nyob rau hauv preclinical thiab soj ntsuam kev tshawb fawb, nrog rau kev tshawb fawb rau NAFLD, MASLD, thiab daim siab mob cancer tiv thaiv [2].

Cov lus nug nquag nug (FAQ)

Q: Dab tsi yog qhov txawv ntawm ursodeoxycholic acid (UDCA) thiab ursodiol?

A: Lawv yog chemically tib yam. Ursodiol yog US Adopted Name (USAN) rau cov tshuaj, thaum ursodeoxycholic acid yog lub npe tshuaj. Ob leeg xa mus rau tib lub ntsiab lus.

Q: UDCA ruaj khov npaum li cas, thiab yuav tsum khaws nws li cas?

A: UDCA ruaj khov thaum khaws cia zoo. Rau txee lub neej ntawm 36-48 lub hlis, khaws cia rau hauv cov thawv kaw nruj nreem, tiv thaiv lub teeb thiab noo noo, ntawm 2-8℃(txias). Short-term cia ntawm chav tsev kub (<25°C) in dry conditions is acceptable for limited durations.

Q: Cov kev xaiv ntim khoom twg muaj?

A: Pharmaceutical-grade ntim rau hauv cov hnab ntawv txhuas (1-5 kg), ntim yas nruas (10-25 kg), fiber ntau nruas (25-50 kg), thiab ntim customized rau cov khoom tiav.

Q: Lub sij hawm ua ntej rau kev txiav txim ntau yog dab tsi?

A: Standard bulk orders (Ntau tshaj los yog sib npaug rau 25 kg) feem ntau xa tuaj nyob rau hauv 10-15 hnub ua hauj lwm tom qab kev txiav txim pom zoo.

Vim li cas thiaj xaiv peb?

Koj tus kws tshaj lij kev tsim khoom & Sourcing tus khub

Peb yog ntau tshaj li tus neeg xa khoom - peb yog cov khoom lag luam sib txuas sib txuas rau siab - cov khoom xyaw zoo, cov qauv kev cai, thiab cov khoom tiav thoob plaws ntau qhov kev lag luam.

Cov kws tshaj lij

Nrog rau ntau xyoo ntawm kev paub hauv cov nroj tsuag extracts, khoom noj khoom haus additives, cosmetic raw cov ntaub ntawv, thiab cov khoom noj khoom haus, peb pab neeg coj cov kev txawj ntse txawj ntse thiab kev ua lag luam kev pom zoo rau txhua qhov kev koom tes.

Ntau Yam Khoom Muag

Peb muab ntau yam khoom lag luam, suav nrog cov khoom noj khoom haus ntxiv, cov nroj tsuag rho tawm, txiv hmab txiv ntoo & zaub hmoov, cov khoom siv tshuaj pleev ib ce, thiab cov khoom xyaw ua zaub mov.

Ib -Stop Shop

Raw Khoom:High -cov khoom xyaw purity rau zaub mov, dej haus, ntxiv, thiab kev siv tshuaj pleev ib ce.

Cov khoom tiav:Hauv -tsev tsim cov tshuaj ntsiav, mos gels, gummies, kua tee, thiab hmoov sib tov.

Kev pabcuam OEM / ODM / OBM

Label Design & Ntim:Custom branding tailored rau koj lub hom phiaj kev lag luam.

Formulation & R & D:Cov kws tshaj lij kev txhawb nqa los tsim cov kev cai sib xyaw, cov qauv tsim muaj, thiab cov khoom tsim tshiab.

Ntiaj teb no Logistics:Txhim khu kev xa khoom, cov ntaub ntawv, thiab kev pabcuam kev lis kev cai.

Quality Assurance

Kev nruj nruj raws li GMP cov qauv thiab tag nrho cov kev cai pob tshab. Peb nyob twj ywm tam sim no nrog cov kev cai thoob ntiaj teb, suav nrog FDA GRAS, EFSA, thiab lwm yam kev cai hauv cheeb tsam, kom ntseeg tau tias koj cov khoom ua tau raws li qhov kev nyab xeeb siab tshaj plaws thiab ua raws li cov qauv.

Ua tam sim no

Npaj kom suav nrog hwmUrsodeoxycholic Acid (UDCA) hmoovrau hauv koj cov tshuaj, nutraceutical, lossis tsiaj noj qab haus huv cov khoom?

Tiv tauj peb hnub no rau:

Certificate of Analysis (COA) thiab Material Safety Data Sheet (MSDS)
Kev xaiv ntim khoom (khoom siv tshuaj, qib private-label)
Cov qauv kuaj dawb dawb (1 kg) rau kev sim tshuaj thiab batch tsim nyog

Thov hu rau peb ntawmella.zhang@huilinbio-tech.com.

OEM/ODM/OBM Services

operating room

Packaging and Transportation

Certificates and laboratories

Payment methods

Cov ntaub ntawv

[1]Kumar D, Tandon RK. Kev siv ursodeoxycholic acid hauv daim siab mob.Phau ntawv Journal of Gastroenterology thiab Hepatology. 2001; 16(1):3-14. doi: 10.1046/j.1440-1746.2001.02376.x

[2]Besson F, et al. UDCA rau Kab Mob Ntshav Qab Zib: Kev Kho Mob thiab Pathphysiological Basis.Seminars nyob rau hauv kab mob siab. 2024; 44(1). doi: 10.1055/s-0044-1779520

[3]Rashidbeygi E, et al. Cov teebmeem ntawm ursodeoxycholic acid ntawm cardiometabolic cov yam ntxwv muaj feem cuam tshuam: kev tshuaj xyuas thiab kev tshuaj xyuas meta-tshaj tawm ntawm kev sim tshuaj ntsuam xyuas.BMC Cardiovascular Disorders. 2025; 25(1):125. doi: 10.1186/s12872-025-04549-3 ib

[4]Zaidi MH, et al. Peroxisome Proliferator-Activated Receptor (PPAR) Agonists rau cov neeg mob uas muaj tus kab mob biliary Cholangitis thawj zaug nrog cov lus teb tsis txaus rau Ursodeoxycholic Acid (UDCA): Kev Ntsuam Xyuas Txheej Txheem thiab Meta-Tshaj Tawm ntawm Randomized Controlled Trials.JGH Qhib. 2025;9(6):e70196. doi: 10.1002/jh3.70196

[5]Bacq Y, et al. Kev ua tau zoo ntawm ursodeoxycholic acid hauv kev kho mob intrahepatic cholestasis ntawm cev xeeb tub: kev tshuaj ntsuam meta.Gastroenterology. 2012; 143(6): 1492-501. doi: 10.1053/j.gastro.2012.08.004

Cim npe nrov: ursodeoxycholic acid (udca) hmoov, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, ntuj, zoo, Tshuag, kev muag