Taw qhia
3-O-Ethyl-L-ascorbic Acidyog ib qho ruaj khov thiab roj -soluble derivative ntawm ntshiab vitamin C (L-ascorbic acid). Los ntawm kev qhia ib pab pawg ethyl ntawm txoj hauj lwm thib 3, qhov derivative no kov yeej cov kev txwv loj ntawm L-ascorbic acid- xws li, nws tsis ruaj khov hauv dej, cua sov, thiab huab cua- thaum khaws nws cov kev ua haujlwm lom neeg muaj zog. Nws zoo nkag mus rau ntawm daim tawv nqaij barrier thiab hloov mus rau hauv active L-ascorbic acid nyob rau hauv daim tawv nqaij, ua rau nws yog ib tug pob zeb muaj nyob rau hauv ruaj khov thiab zoo tshuaj pleev ib ce formulations tsom brightness, anti- laus, thiab antioxidant tiv thaiv.[1].
Biochemical & Physical Parameters
| Parameter | Specification |
|---|---|
| CAS Nr. | 86404-04-8 |
| Molecular Formula | C₈H₁₂O₆ |
| Molecular Luj | 204.18 g / mol |
| Qhov tshwm sim | Dawb rau tawm -dawb crystalline hmoov |
| Kev ntsuam xyuas (HPLC) | Ntau dua lossis sib npaug li 98.0% |
| Solubility | Soluble hauv roj, ethanol, thiab dej (txog 4%) |
| pH (1% daws) | ~2.5 - 3.5 |
Mechanism of Action: Tus Superior Bioavailable Precursor
Kev ua tau zoo ntawm3-O-Ethyl-L-ascorbic Acidyog raws li nws cov qauv tshwj xeeb, uas muab ob qho tib si stability thiab kev xa khoom zoo:
1. Txhim khu kev ruaj ntseg & nkag mus:Cov pab pawg ethyl tiv thaiv cov qauv ediol ntawm Vitamin C, uas yog feem ntau ua rau oxidation. Qhov no ua rau cov molecule ruaj khov nyob rau hauv aqueous formulations thiab resistant rau lub teeb thiab kub. Tsis tas li ntawd, nws qhov xwm txheej amphiphilic (vim yog pawg ethyl) tso cai rau nws nkag mus rau stratum corneum zoo dua li dej -soluble L-ascorbic acid.
2. Intracellular Hloov & Kev Ua Haujlwm:Thaum nyob rau hauv cov tawv nqaij hlwb (keratinocytes thiab fibroblasts), ethyl ether daim ntawv cog lus yog enzymatically cleaved, tso active L-ascorbic acid ncaj qha rau ntawm lub hom phiaj.[2]. Lub freed L-ascorbic acid ces exerts nws biological functions los ntawm:
- Pub Electrons:Ncaj nraim neutralizing dawb radicals zoo li superoxide anion thiab hydroxyl radical.
- Regenerating Vitamin E:Recycling oxidized Vitamin E rov qab mus rau nws daim ntawv nquag hauv daim tawv nqaij.
- Ua raws li Cofactor:Ua haujlwm ua ib qho tseem ceeb cofactor rau cov enzymes koom nrog hauv collagen synthesis thiab kev tswj melanin.
Cov txiaj ntsig tseem ceeb ntawm 3-O-Ethyl-L-ascorbic Acid hauv Skincare
- Superior Stability:Nyob ruaj khov nyob rau hauv dej-raws li cov qauv rau ntau tshaj 24 lub hlis, tiv thaiv kom txhob daj thiab degradation txuam nrog ntshiab L-ascorbic acid. Qhov no txuas ntxiv cov khoom txee lub neej thiab ua kom muaj txiaj ntsig zoo ib yam.
- Cov tawv nqaij muaj zog Brightening:Zoo inhibits enzyme tyrosinase, tseem ceeb heev rau melanin ntau lawm. Qhov no ua rau txo qis ntawm qhov pom ntawm qhov tsaus nti, hyperpigmentation, thiab melasma, txhawb nqa cov tawv nqaij ntau dua thiab ci ntsa iab.[3].
- Boosts Collagen Production:Stimulates fibroblast kev ua si thiab ua raws li cofactor rau prolyl hydroxylase thiab lysyl hydroxylase, enzymes tsim nyog rau kev tsim collagen. Qhov no pab txo cov tsos ntawm cov kab zoo thiab wrinkles thiab txhim kho daim tawv nqaij firmness.
- Muaj zog Antioxidant Protection:Muab kev tiv thaiv zoo tiv thaiv oxidative kev ntxhov siab vim los ntawm UV raug thiab muaj kuab paug, pab tiv thaiv kev yees duab.
- Yooj yim rau ntawm daim tawv nqaij:Nws cov xwm txheej ruaj khov thiab nruab nrab pH ua rau nws tsis tshua khaus dua li qis -pH L-ascorbic acid, haum rau cov tawv nqaij rhiab heev.
3-O-Ethyl-L-ascorbic Acid vs. Lwm daim ntawv vitamin C
| Feature | 3-O-Ethyl-L-ascorbic Acid | L-Ascorbic Acid (Ntshiab VC) | Tetrahexyldecyl Ascorbate (THD Ascorbate) |
|---|---|---|---|
| Kev ruaj ntseg | Zoo heev.Stable nyob rau hauv dej thiab huab cua. | Neeg pluag heev.Oxidizes sai sai hauv dej thiab cua. | Zoo heev.ruaj khov hauv cov roj. |
| Solubility | Amphiphilic.Soluble hauv dej thiab roj. | Dej- soluble nkaus xwb. | Roj-soluble nkaus xwb. |
| Daim tawv nqaij nkag | Zoo heev.Vim nws qhov xwm txheej amphiphilic. | txwv.Vim nws hydrophilicity. | Zoo heev.Vim lipophilicity siab. |
| Bioavailability | Siab.Hloov mus rau VC hauv daim tawv nqaij. | Ncaj qha.Tab sis yooj yim degraded ua ntej nkag. | Siab.Hloov mus rau VC hauv daim tawv nqaij. |
| Irritation Potential | Tsawg. | Siab(ntawm qhov zoo pH tsawg). | Tsawg heev. |
Cov ntawv thov hauv Kev Lag Luam
3-O-Ethyl-L-ascorbic Acid Hmoovyog ntau yam rau ntau yam khoom siv tawv nqaij:
1. Brightening & Whitening Serums:Raws li ib tug tseem ceeb active rau lub hom phiaj hyperpigmentation.
2. Anti-Aging Creams & Lotions:Txhawm rau txhawb collagen thiab tiv thaiv wrinkles.
3. Essences & Toners:Rau lub teeb yuag, hydrating antioxidant txheej.
4. Roj-hauv- Dej (O/W) Emulsions:Nws ruaj khov ua rau nws zoo tagnrho rau ntau yam ntawm emulsion-raws li cov khoom.
5. Tshuaj pleev thaiv hnub & hnub cream:Txhawm rau muab kev tiv thaiv antioxidant tiv thaiv UV- ua rau muaj kev puas tsuaj.
Formulation Reference
Basic Stable Vitamin C Brightening Serum:
1. Phaj Dej (84.5%):
- Deionized dej: qs rau 100%
- Glycerin: 5%
2. 3-O-Ethyl-L-ascorbic Acid Powder: 2%(Ua ntej- dissolve nyob rau hauv me me dej sov los yog propylene glycol)
- Actives & Preservatives (3.5%):
- Niacinamide: 3% (Txhim kho qhov sib npaug thiab pH sib npaug)
- Phenoxyethanol thiab Ethylhexylglycerin: 0.5%
3. Cov lus qhia:Ua ntej- dissolve 3-O-Ethyl Ascorbic Acid hmoov. Ntxiv rau lub ntsiab dej theem nrog glycerin. Sib tov zoo. Thaum kawg, ntxiv cov preservative. pH feem ntau yog nyob rau hauv ntau yam tsis muaj kev hloov kho.
Cov lus nug nquag nug (FAQ)
Q: Nws piv li L-ascorbic acid li cas?
A: Nws yog ib qho ruaj khov derivative ntawm L-ascorbic acid. Thaum L-ascorbic acid yog cov vitamin C ntshiab tab sis tsis ruaj khov, 3-O-Ethyl Ascorbic Acid muaj kev ruaj ntseg zoo tshaj plaws hauv cov qauv, zoo ntawm daim tawv nqaij nkag mus, thiab hloov mus rau L-ascorbic acid nyob rau hauv daim tawv nqaij, ua rau nws muaj kev ntseeg siab thiab maj mam xaiv rau cov khoom kom zoo nkauj.
Q: Puas muaj kev phiv tshuaj?
A: Nws yog feem ntau zoo - zam thiab pom tias tsis yog - khaus thiab tsis yog - rhiab heev. Nws cov ntaub ntawv maj mam ua rau nws haum rau cov tawv nqaij rhiab, tsis zoo li qhov ua rau khaus los ntawm qis -pH L- ascorbic acid formulations. Ib txwm ua qhov ntsuas patch rau cov khoom tshiab.
Q: Dab tsi yog qhov pom zoo siv concentration?
A: Qhov kev siv tau zoo yog feem ntau ntawm 0.5% txog 3.0% hauv qhov kawg tsim. Ib qho concentration ntawm 2% yog ib qho tseem ceeb rau brightening thiab antioxidant teebmeem.
Q: Nws puas zoo ib yam li Ethyl Ascorbic Acid?
A: Yog, "3-O-Ethyl-L-ascorbic Acid" yog lub npe tshuaj meej, thaum "Ethyl Ascorbic Acid" yog ib lub npe luv rau tib yam khoom. Lawv xa mus rau qhov zoo sib xws.
Tiv tauj peb
Tsim kom muaj kev ntseeg siab siv qhov ruaj khov thiab muaj zog3-O-Ethyl-L-ascorbic Acid Powder (CAS 86404-04-8). Txhawb nqa koj cov kab kev tu tawv nqaij nrog cov pov thawj vitamin C derivative uas ua rau pom kev ci ntsa iab thiab tiv thaiv - cov txiaj ntsig kev laus. Hu rau peb hnub no kom thov ib tus qauv, daim ntawv pov thawj ntawm kev tsom xam (CoA), thiab daim ntawv qhia kev.
E-mail:ella.zhang@huilinbio-tech.com.
Cov ntaub ntawv
- Iliopoulos, F., Sil, BC, Moore, DJ, Lucas, RA, & Lane, ME (2019). 3-O-ethyl-l-ascorbic acid: Tus cwj pwm thiab kev tshawb nrhiav ntawm tib lub cev hnyav rau kev xa mus rau ntawm daim tawv nqaij.International Journal of Pharmaceutics: X, *1*, 100025
- Al-Niaimi, F., & Chiang, NYZ (2017). Topical Vitamin C thiab daim tawv nqaij: Mechanisms of Action and Clinical Applications.Phau ntawv Journal of Clinical and Aesthetic Dermatology, *10*(7), 14–17.
- Chen, SJ, et al. (2021). Cov tshuaj tiv thaiv -melanogenic cuam tshuam ntawm 3-O-ethyl ascorbic acid ntawm Nrf2-mediated -MSH inhibition hauv UVA-irradiated keratinocytes thiab autophagy induction hauv melanocytes.Dawb radical biology thiab tshuaj, *173*, 151–169
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