Taw qhia
Hinokitiol ({0}}Thujalicin)yog lub ntuj monoterpenoid compound pom nyob rau hauv lub plawv ntawm cupressaceous nroj tsuag, xws li Taiwanese hinoki cypress. Qhov sib txawv ntawm xya -cov tswv cuab tropolone derivative muaj npe nrov rau nws qhov dav -spectrum antimicrobial kev ua haujlwm tiv thaiv kab mob, fungi, thiab kab mob. Tshaj li nws cov khoom khaws cia, Hinokitiol nthuav tawm cov haujlwm lom neeg zoo kawg li, suav nrog kev tiv thaiv - mob, antioxidant, thiab hlau- chelating peev xwm, ua rau nws muaj ntau yam thiab muaj txiaj ntsig zoo hauv cov tshuaj pleev ib ce, tshuaj, thiab kev noj qab haus huv.[1].
Biochemical & Physical Parameters
| Parameter | Specification |
|---|---|
| CAS Nr. | 499-44-5 |
| Molecular Formula | C₁₀H₁₂O₂ |
| Molecular Luj | 164.20 g / mol |
| Qhov tshwm sim | tawm -dawb crystalline hmoov |
| Kev ntsuam xyuas (HPLC) | Ntau dua lossis sib npaug li 98.0% |
| Melting Point | 50 - 52 degree |
| Solubility | Soluble hauv ethanol, roj; sparingly soluble hauv dej. |
Mechanism ntawm Action
Multifaceted kev ua tau zoo ntawmHinokitiolstems los ntawm nws cov qauv tshuaj tshwj xeeb thiab nws cov kev sib cuam tshuam ntawm qib cellular thiab molecular:
Muaj zog hlau Chelation
Hinokitiol tus qauv tropolone muaj kev sib raug zoo rau cov hlau ions, tshwj xeebhlau (Fe²⁺/Fe³⁺). Los ntawm chelating tseem ceeb hlau, nws cuam tshuam cov txheej txheem microbial tseem ceeb xws li kev thauj khoom hluav taws xob thiab enzyme catalysis (xws li, hauv ribonucleotide reductase), ua rau muaj zog bacteriostatic thiab fungistatic teebmeem.[2]. Cov txheej txheem tib yam no tuaj yeem hloov kho hlau- cov txheej txheem nyob ntawm tib neeg lub hlwb, xws li inhibiting melanogenesis.
01
Membrane Disruption & Cellular Uptake
Nws cov lipophilic xwm tso cai rau nws mus koom ua ke thiab cuam tshuam kev ncaj ncees ntawm microbial cell membranes. Tsis tas li ntawd, nws cov hlau -chelating cov cuab yeej tuaj yeem pab txhawb nws txoj kev thauj mus los rau hauv ob qho tib si microbial thiab mammalian hlwb ntawm hlau-txoj kev thauj mus los, xws li txoj kev hloov pauv receptor, uas tso cai rau nws ua rau muaj kev cuam tshuam hauv lub cev.
02
Inhibition ntawm Tyrosinase
Los ntawm chelating tooj liab ion ntawm qhov chaw nquag ntawm tyrosinase enzyme, Hinokitiol zoo inhibits melanin ntau lawm, uas yog cov txheej txheem tseem ceeb hauv daim tawv nqaij pigmentation.[3].
03
Kev tiv thaiv -inflammatory Action
Hinokitiol tau pom tias yuav txwv tsis pub tsim cov pro-inflammatory cytokines (xws li, TNF- , IL-6) los ntawm inhibiting NF-κB signaling pathway, yog li calming o.
04
Cov txiaj ntsig tseem ceeb ntawm Hinokitiol
Dav -Spectrum Preservation:Ua hauj lwm raws li ib tug haib, natural preservative booster nyob rau hauv cov tshuaj pleev ib ce formulations, tiv thaiv ntau yam kab mob thiab fungi.
Acne Management & Skin Soothing:Nws muaj zog tiv thaiv - kab mob (tshwj xeeb tshaj yog tawm tsamC. pob txuv) thiab los tiv thaiv- cov khoom ua kom mob ua rau nws muaj txiaj ntsig zoo rau kev txo pob pob txuv thiab ua kom muaj kev sib haum xeeb liab thiab khaus khaus.
Daim tawv nqaij Brightening & Hyperpigmentation Control:Raws li ib qho zoo tyrosinase inhibitor, nws yuav pab kom ploj qhov chaw tsaus, lub hnub melasma, thiab melasma, txhawb cov tawv nqaij ntau dua thiab ci ntsa iab.
Scalp & Hair Health:Pab tswj cov tawv nqaij noj qab haus huv microbiome, txo cov dandruff thiab khaus khaus. Nws kuj tseem tuaj yeem pab txhawb cov plaub hau follicle.
Kho qhov ncauj:Siv hauv cov tshuaj ntxuav qhov ncauj thiab tshuaj txhuam hniav rau nws cov tshuaj tua kab mob tiv thaiv kab mob cariogenic thiab periodontopathic, txhawb cov pos hniav thiab ua pa tshiab.
Kev them nyiaj yug Antioxidant:Tshem tawm cov dawb radicals, muab kev tiv thaiv oxidative kev nyuaj siab uas ua rau cov tawv nqaij laus.
Cov ntawv thov hauv Kev Lag Luam
Hinokitiol hmoovyog ib tug ntau yam active rau ib tug ntau yam ntawm advanced formulations:
Cosmetic & Skincare:
Kev kho pob txuv:Nyob rau hauv cov tshuaj, tshuaj pleev ib ce, thiab cleansers.
Brightening Serums & Creams:Rau cov hom phiaj hyperpigmentation.
Preservative -Boosted Formulas:Txhawm rau txhim kho lub txee- lub neej ntawm cov khoom ntuj.
Sensitive Skin Products:Siv nws cov mos mos tab sis muaj txiaj ntsig zoo los tiv thaiv - cov khoom inflammatory.
Kev tu plaub hau:
Anti- tshuaj zawv plaub hau & Kev kho tawv taub hau.
Kho qhov ncauj:
Cov tshuaj txhuam hniav, tshuaj txhuam hniav, thiab gelsrau kev tu cev ntawm qhov ncauj.
Khoom noj khoom haus:
Encapsulated rau lub cev tiv thaiv kab mob thiab kev noj qab haus huv kev txhawb nqa (ua raws li kev pom zoo hauv cheeb tsam tswj hwm).
Cov lus nug nquag nug (FAQ)
Q: Cov txiaj ntsig tseem ceeb ntawm Hinokitiol rau daim tawv nqaij yog dab tsi?
A: Nws cov txiaj ntsig tseem ceeb ntawm daim tawv nqaij muaj xws li kev tawm tsam pob txuv- ua rau cov kab mob, ua kom mob, ua kom pom kev tsaus ntuj los ntawm inhibiting melanin ntau lawm, thiab muab kev tiv thaiv antioxidant. Nws yog ib qho khoom siv ntau- ua haujlwm kom pom tseeb, siab tawv, thiab ci tawv nqaij.
Q: Puas yog Hinokitiol muaj kev nyab xeeb? Puas muaj tej yam tshwm sim?
A: Hinokitiol feem ntau suav hais tias muaj kev nyab xeeb rau kev siv tshuaj pleev ib ce ntawm qhov tsis tshua muaj siab (feem ntau 0.01% - 0.5%). Raws li nrog rau txhua lub zog muaj zog, ntau dua tuaj yeem ua rau tawv nqaij khaus lossis rhiab heev rau qee tus neeg. Nws yog ib qho tseem ceeb kom ua raws li kev pom zoo siv qib thiab ua qhov ntsuas patch. Nws siv nyob rau hauv qhov ncauj tshuaj yuav tsum tau ua tib zoo soj ntsuam raws li cov cai hauv cheeb tsam.
Q: Hinokitiol qhov hnyav molecular cuam tshuam nws txoj haujlwm li cas?
A: Nrog rau qhov hnyav molecular tsawg ntawm 164.20 g / mol, Hinokitiol yog qhov me me txaus kom nkag mus rau ntawm daim tawv nqaij thiab siv nws cov kev ua ntawm qib cellular, ua rau nws ua tau zoo.
Q: Hinokitiol puas tuaj yeem siv nrog lwm yam khoom siv?
A: Yog, nws tuaj yeem tsim nrog ntau lwm yam khoom siv. Txawm li cas los xij, kev ceev faj yuav tsum tau siv thaum sib txuas nrog lwm cov hlau - cov neeg ua haujlwm chelating lossis cov ntsiab lus siab ntawm ionic compounds, vim qhov no yuav cuam tshuam rau nws txoj kev ruaj ntseg lossis kev ua tau zoo. Kev ntsuam xyuas kev sib raug zoo yog ib txwm pom zoo.
Tiv tauj peb
Xauv lub zog ntawm qhov muaj ntau yam kev tiv thaiv molecule. Tsim nrog peb siab -purityHinokitiol hmoov (CAS 499-44-5)los tsim cov kev tu tawv nqaij tshiab, kho qhov ncauj, thiab cov khoom noj qab haus huv nrog cov pov thawj ua tau zoo. Hu rau peb hnub no kom thov ib tus qauv, daim ntawv pov thawj ntawm kev tsom xam (CoA), thiab cov ntaub ntawv ntxaws ntxaws.
E-mail:ella.zhang@huilinbio-tech.com.
Cov ntaub ntawv
- Le, C.-Y., et al. (2023). Hinokitiol Selectively Enhances Antibacterial Activity ntawm Tetracyclines tawm tsamStaphylococcus aureus. Microbiology Spectrum, *11*(2), e03205-22.
- Domon, H., et al. (2019). Cov kab mob tua kab mob ntawm hinokitiol tawm tsam ob qho tib si tshuaj tua kab mob- tiv taus thiab - cov kab mob kis tau yooj yim uas muaj nyob hauv qhov ncauj kab noj hniav thiab cov pa sab saud.Microbiology thiab Immunology, *63*(6), 213–222.
- Tsao, Y.-T., et al. (2016). Hinokitiol Inhibits Melanogenesis ntawm AKT/mTOR Kev Qhia hauv B16F10 nas Melanoma Cells.International Journal of Molecular Sciences, *17*(2), 248.
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