Palmitoyl Tripeptide -5

Khoom Taw Qhia

Palmitoyl tripeptide -5yog qhov ntxov tshaj plaws thiab feem ntau siv tshuaj pleev ib ce peptide hauv peptide series. Raws li lub npe implies, palmitoyl txuas nrog tripeptide, thiab grafting ntawm palmitoyl yuav pab tau kom nkag mus rau ntawm daim tawv nqaij zoo dua los ntawm cov kab mob lom thiab lipid membrane (hydrophilic peptide ntu thiab hydrophobic palmitoyl kawg, hydrophilic thiab lipophilic). Nws tuaj yeem txhawb cov synthesis ntawm collagen thiab elastin hauv dermis. Palmitoyl tripeptide -5 txhawb nqa cov synthesis ntawm daim tawv nqaij collagen los ntawm cov ntaub so ntswg loj hlob (TGF-), yog li ua tiav lub hom phiaj ntawm smoothing wrinkles thiab firming ntawm daim tawv nqaij. Zoo ib yam li cov khoom siv tshuaj tiv thaiv kab mob, xws li derivatives ntawm vitamin C thiab vitamin A. Kev tshawb fawb ntawm P&G lub tuam txhab qhia tau hais tias palmitoyl pentapeptide -3 tuaj yeem txhawb kev tsim cov collagen thiab lwm yam extracellular matrix proteins (xws li elastin thiab fibronectin, etc.), uas yog vim li cas nws yog dav siv. Nyob rau hauv Suav teb, hom me me-molecule cosmetic peptides tseem nyob rau hauv thawj theem thiab imitation theem, tab sis me me-molecule peptides nrog 3 los yog 4 amino acids yog tsim los ntawm cov txheej txheem solid-theem, thiab kev lag luam kev zoo nkauj kuj tuaj yeem qiv cov tshuab hluavtaws. ntawm tshuaj peptides.

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Lub luag haujlwm ntawm palmitoyl tripeptide -5

Palmitoyl tripeptide -5, nws cov nyhuv tshuaj pleev ib ce tuaj yeem muab piv rau kev txhaj tshuaj collagen. Nws tuaj yeem txhawb cov synthesis ntawm collagen thiab glucosamine nyob rau hauv tib neeg fibrous hlwb, ntxiv dag zog rau cov ntaub so ntswg, ua kom tawv nqaij firmness thiab txhawb kev ua haujlwm ntawm tes; Inhibition ntawm oxygen dawb radicals thiab hydroxyl dawb radicals txhawb cov synthesis ntawm matrix proteins, tshwj xeeb tshaj yog collagen, thiab kuj yuav ua rau kom cov elastin, hyaluronic acid, glycosaminoglycan thiab fibronectin. Thaum ntxiv rau cov tshuaj pleev ib ce, nws tuaj yeem ntxiv collagen rau ntawm daim tawv nqaij, txhim kho nws elasticity thiab txo lub ntsej muag wrinkles; Muaj peev xwm ua kom cov tawv nqaij noo noo, rov qab smoothness thiab firmness, txhim kho daim tawv nqaij xim, thiab txhim kho luster thiab pob tshab; Tsis tas li ntawd, nws kuj muaj cov nyhuv moistening daim di ncauj. Hom kev ua haujlwm zoo ib yam li retinoic acid, tab sis tsis muaj kev phiv ntawm retinoic acid, uas ua rau kom cov synthesis ntawm collagen thiab interstitial hyaluronic acid (HA), ua rau cov kab zoo ploj thiab ua rau cov tawv nqaij ruaj khov.

Mechanism ntawm palmitoyl tripeptide -5

Palmitoyl tripeptide -5 yog cov khoom siv tshuaj pleev ib ce me me molecular peptide, uas tuaj yeem txhawb kev sib txuas ntawm collagen thiab elastin hauv dermis. Palmitoyl tripeptide -5 belongs rau lub teeb liab peptide. Cov kev tshawb fawb pom tau hais tias cov peptides no tuaj yeem txhawb kev sib txuas ntawm collagen (hom I, hom II thiab hom IV) thiab tsim cov proteins hauv matrix extracellular los ntawm kev ua haujlwm ntawm cov hlwb stromal, ua rau daim tawv nqaij zoo dua thiab elastic dua. Palmitoyl tripeptide -5 tuaj yeem txhawb nqa cov synthesis ntawm collagen thiab elastin hauv dermis, thiab yog ib qho khoom siv zoo tshaj plaws rau kev ua kom cov collagen ntau lawm thiab kho wrinkles. Ntxiv palmitoyl tripeptide -5 rau cov tshuaj pleev ib ce tuaj yeem pab cov tawv nqaij ntxiv collagen, txhim kho lub ntsej muag elasticity thiab txo cov ntsej muag wrinkles. Nyob rau tib lub sijhawm, nws kuj muaj cov yam ntxwv ntawm kev txhim kho cov haujlwm ntawm tes, ua kom cov tawv nqaij noo noo, txhim kho daim tawv nqaij ci thiab txhim kho cov xim ntawm daim tawv nqaij.

Kev npaj technology ntawm palmitoyl tripeptide -5

Kev tiv thaiv cov amino acids: Ua ntej, nws yog ib qho tsim nyog yuav tsum xaiv cov amino acids tsim nyog los tsim cov chains pentapeptide. Cov amino acids no yuav tsum muaj kev tiv thaiv kom tsis txhob muaj kev cuam tshuam tsis tsim nyog thaum lub sijhawm sib txuas. Cov pab pawg tiv thaiv feem ntau suav nrog BOC (tert-butyloxycarbonyl) lossis Fmoc (9-fluoronymethoxycarbonyl).
Synthesis cov tshuaj tiv thaiv: Tom ntej no, cov saw pentapeptide yog tsim los ntawm cov khoom-theem synthesis los yog kua-theem synthesis nyob rau hauv cov txheej txheem ntawm maj ntxiv amino acid monomers. Nyob rau hauv txhua kauj ruam ntawm cov tshuaj tiv thaiv, nws yog ib qhov tsim nyog los ua ke cov amino acid monomer sib xyaw nrog cov saw hlau polypeptide synthesized. Activators (xws li DIC, HATU, thiab lwm yam) thiab cov hauv paus (xws li dimethylaminopyrrolidine) feem ntau yog siv los txhawb cov tshuaj tiv thaiv.
Deprotection: Tom qab cov synthesis ntawm pentapeptide saw tiav, cov pab pawg tiv thaiv ntawm cov amino acid yuav tsum tau muab tshem tawm kom rov qab nws cov amino dawb thiab carboxyl pawg. Qhov no feem ntau yog ua tiav los ntawm kev kho cov tshuaj reagents xws li trifluoroacetic acid los yog hydrochloric acid.Purification thiab tsom xam: Tom qab cov synthesis ntawmpalmitoyl tripeptide -5, nws yog ib qho tsim nyog yuav tau ntxuav thiab tshuaj xyuas cov khoom kom tshem tawm cov impurities thiab xyuas kom meej cov purity thiab cov qauv ntawm lub hom phiaj cov khoom. Qhov no feem ntau suav nrog kev siv kab chromatography, kev ua haujlwm siab ua kua chromatography thiab lwm yam txuj ci.

Kev txheeb xyuas txoj kev ntawm palmitoyl tripeptide -5

Kev ua haujlwm siab ua kua chromatography (HPLC): Qhov no yog cov txheej txheem kev tshuaj ntsuam xyuas uas siv ntau, uas tuaj yeem siv los txheeb xyuas thiab txheeb xyuas cov ntsiab lus thiab muaj pes tsawg leeg ntawm cov tshuaj lom neeg. Palmitoyl tripeptide -5 tuaj yeem sib cais thiab kuaj pom los ntawm kev dhau cov qauv los ntawm kab thiab siv cov kuab tshuaj tsim nyog.
Mass Spectrometry: Mass spectrometry tuaj yeem muab cov ncauj lus kom ntxaws txog cov qauv thiab cov khoom sib xyaw. Los ntawm ionizing lub compound nyob rau hauv cov qauv thiab ntsuas nws cov huab hwm coj thiab txheeb ze abundance, nws yuav txiav txim seb nws muaj palmitoyl tripeptide -5.
Spectroscopy: Lub hav zoov ntawm cov ntsiab lus tshwj xeeb hauv cov qauv tuaj yeem txiav txim siab los ntawm infrared spectroscopy lossis ultraviolet-pom spectroscopy. Cov tswv yim no tuaj yeem txheeb xyuas palmitoyl tripeptide -5 raws li cov yam ntxwv ntawm kev nqus lossis emission hauv cov qauv.
Enzyme-linked immunosorbent assay (ELISA): ELISA yog ib txoj hauv kev uas siv biochemical tsom xam, uas tuaj yeem siv los txheeb xyuas qhov muaj cov molecules tshwj xeeb. Lub xub ntiag ntawm palmitoyl tripeptide -5 tuaj yeem txiav txim siab los ntawm kev ua raws li cov qauv nrog cov tshuaj tiv thaiv tshwj xeeb thiab tom qab ntawd kuaj pom nws nrog enzyme-labeled Secondary antibody.
Nuclear Magnetic Resonance (NMR): NMR thev naus laus zis tuaj yeem muab cov ncauj lus kom ntxaws txog cov qauv molecular thiab muaj pes tsawg leeg hauv cov qauv. Los ntawm kev tshuaj xyuas NMR spectrum ntawm tus qauv, nws tuaj yeem txiav txim siab seb nws puas muaj palmitoyl tripeptide -5.

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• Peb muaj ib pab neeg tshawb fawb txog kev tshawb fawb thiab kev loj hlob ntawm Palmitoyl Tripeptide -5. Lawv koom tes nrog ntau lub tsev kawm tshawb fawb thiab tsev kawm qib siab los tsim kho tshiab thiab txhim kho tas li kom lawv cov khoom sib tw hauv kev ua lag luam. Peb them sai sai rau qhov kev tshawb fawb tshawb fawb tshiab thiab cov qauv kev lag luam los xyuas kom meej qhov zoo thiab cov txiaj ntsig ntawm cov khoom.
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