Koj puas tau xav txog cov khoom siv tawv nqaij uas ua tauib ntus du qhia kabnrog ib tug mechanism tshwm sim los ntawm xwm, tsis tau muaj kev nyab xeeb thiab synthetically tsim rau cosmetic siv? Nkag musDipeptide Diaminobutyroyl Benzylamide Diacetate, dav paub los ntawm nws lub npe lag luamSyn-Ake®. Qhov kev tsim kho tshiab peptide no tau dhau los ua lub hnub qub muaj nyob hauv kev tiv thaiv - cov qauv kev laus, cog lus rautsis yog -invasive mus kom ze kom txo tau cov tsos ntawm wrinkles.
Tab sis qhov tseeb yog dab tsi, thiab nws ua haujlwm li cas? Phau ntawv qhia no dhia mus rau hauv kev tshawb fawb, cov txiaj ntsig, thiab kev nyab xeeb ntawm cov molecule ntxim nyiam no los pab koj nkag siab tias vim li cas nws tau nthuav tawm hauv ntau qib siab.Syn-Ake serumsthiab cream.
Decoding lub npe: Synthetic Tripeptide
Thaum nws cov tshuaj npe suab nyuaj, lub tswv yim yog ncaj nraim. Nws yog ibhluavtaws tripeptide, txhais tau hais tias nws yog cov saw ntawm peb cov amino acid-zoo li lub tsev thaiv, tsim kom zoo nkauj hauv chav kuaj.
- Dipeptide Diaminobutyroyl Benzylamide Diacetateyog nws tus qauv tshuaj npe.
- INCI npe: Lub npe International Nomenclature of Cosmetic Ingredients (INCI) lub npe, uas koj yuav pom ntawm cov npe khoom, yogDIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE.
- CAS Nr: Nws tus cim chemical identifier yog823202-99-9.
- Common npe: Koj feem ntau yuav pom nws marketed liSyn-Ake®, los yog hu ua "snake peptide" los yog "wrinkle-relaxing peptide".
Nws yog muab los ua dawb rau tawm - cov hmoov dawb uas yog soluble hauv dej, ua rau nws haum rau ntau hom tshuaj pleev ib ce, los ntawm lub teeb yuagSyn-Ake serumsrau nplua nuj cream.
Kev Tshawb Fawb Txog Kev Ua: Yuav Ua Li Cas Syn-Ake Ua Haujlwm?
Lub "Ake" hauv Syn-Ake muab cov lus qhia. Nws yog ib tug hluavtaws analogue tsim los ua raws li cov nyhuv ntawm peptide pom nyob rau hauv lub venom ntawm lubTuam Tsev Viper (Tropidolaemus wagleri)[2]. Tab sis qhov tseem ceeb, nws tsis yog tshuaj lom - nws yog ib qho kev nyab xeeb, hluavtaws luam ntawm ib qho tshwj xeebwrinkle - smoothing mechanism.
Primary Mechanism: Muscle Relaxation
Lub peptide yog thawj thiab zoo tshaj plaws - nkag siab txog qhov ua tau zoo li athim rov qab kev sib tw antagonist ntawm cov leeg - hom nicotinic acetylcholine receptors (nmAChR).
- Thaum lub ntsej muag nthuav tawm, cov hlab ntsha tso tawm cov teeb liab molecule hu ua acetylcholine.
- Acetylcholine khi rau receptors ntawm cov leeg nqaij, ua rau lawv cog lus thiab tsim cov tawv nqaij tawv (xws li frown kab lossis crow's ko taw).
- Syn-Ake kev sib tw khi rau tib cov receptors, ua haujlwm zoo li cov ntaub thaiv npog ntawm cov leeg.
- Qhov no ib ntus thaiv acetylcholine los ntawm kev khi, ua rau aso ntawm lub hauv paus ntawm lub ntsej muag nqaijthiab softening ntawm daim tawv nqaij overlying wrinkles.
Tshaj li kev so: Muaj peev xwm tiv thaiv - Txoj Kev Laus
Cov kev tshawb fawb tshiab qhia tau hais tias nws cov txiaj ntsig tuaj yeem txuas ntxiv tshaj qhov yooj yim cov leeg so. A 2023 xam thiabhauv vitrokev tshawb fawb luam tawm nyob rau hauv lubPhau ntawv Journal of Biomolecular Structure thiab Dynamicsqhia tias Syn-Ake kuj tuaj yeem cuam tshuam nrog cov hom phiaj tseem ceeb lom neeg koom nrog hauv kev laus ntawm daim tawv nqaij[1]:
- Inhibition ntawm MMPs: Nws qhia tau tias muaj peev xwm khi rau thiab inhibitMatrix Metalloproteinases (MMPs), tshwj xeeb tshaj yog MMP-13. Cov enzymes no rhuav tshem collagen, thiab lawv cov kev ua haujlwm dhau los yog qhov ua rau tawv nqaij laus thiab sagging.
- Kev ua haujlwm ntawm SIRT1: Txoj kev tshawb no kuj pom tias ruaj khov khi rauSirtuin 1 (SIRT1), ib qho "ntev ntev protein" koom nrog hauv kev kho cellular thiab kev tiv thaiv[1].
- Antioxidant Kev Ua Haujlwm: Tib qhov kev tshawb fawb tau lees paub tias Syn-Ake nthuav tawmconcentration-nyob ntawm kev ua haujlwm antioxidant, pab rau neutralize dawb radicals uas pab rau daim tawv nqaij laus[1].
Qhov ntau- lub hom phiaj muaj peev xwm qhia tau tias Syn-Ake qhov kev txiav txim tuaj yeem yog qhov sib xyaw ua ke ntawmwrinkle tam sim ntawd- smoothing (cov leeg nqaij so) thiab ntev dua -lub sij hawm los tiv thaiv- kev laus (kev tiv thaiv collagen, cellular noj qab haus huv).
Kev Ntsuam Xyuas Cov Ntawv Pov Thawj: Cov Kev Kawm Qhia Li Cas?
Lub cev ntawm kev tshawb fawb ntawm Syn-Ake suav nrog ob qho tib si kev tshawb fawb thiab kev ntsuas kev ua tau zoo:
- Hauv Silico & Hauv Vitro Kev Tshawb Fawb: Txoj kev tshawb no hais txog 2023 tau siv cov khoom siv molecular docking thiab dynamics simulations los kwv yees Syn-Ake qhov kev cuam tshuam ruaj khov nrog MMP-13 thiab SIRT1 receptors, txhawb nqa nws lub peev xwm los ua ntau yam -cov neeg ua haujlwm tiv thaiv kev laus.[1].
- Comparative Efficiency: Qee tus neeg muag khoom thiab cov ntaub ntawv thaum ntxov hais tias nws tuaj yeem ua taumus txog 5 npaug zoo dua li lwm cov peptide technologiesrau txo dynamic wrinkles, nrog rau ib tug tib neeg kev sim qhia ib tug52% txo qis hauv qhov tob tob tom qab 28 hnub ntawm kev siv. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias cov nuj nqis no feem ntau yog los ntawm cov khoom lag luam thiab yuav tsum tau soj ntsuam nyob rau hauv cov ntsiab lus ntawm qhov kawg ntawm cov khoom tsim.
- Nruam Innovation: Kev tshawb fawb txuas ntxiv txhim kho qhov sib xyaw no. Piv txwv li, ib daim ntawv xyoo 2017 tau tshawb fawb txog kev sib xyaw ua ke tshiab ntawm Syn-Ake, nrog ib tus neeg sib tw ua kom pom qhov cuam tshuam sai dua ntawm kev txo cov leeg nqaij ntau zaus hauv cov qauv ntawm tes[3].
Kev nyab xeeb thiab kev tswj hwm kev ua raws cai
Kev nyab xeeb yog qhov tseem ceeb thaum xav txog cov khoom siv tshuaj pleev ib ce.
- Kev ruaj ntseg Profile: Kev tshawb fawb txog toxicological, suav nroghauv vitrocytotoxicity thiab genotoxicity (Ames) kuaj, qhia tias Syn-Ake muajkev ruaj ntseg profilentawm cosmetic concentrations[1].
- Txoj cai tswjfwm hauv Suav teb: Nyob rau hauv Tuam Tshoj txoj kev lag luam tshuaj pleev ib ce, nws tau teev nyob rau hauv lubIECIC(Cov khoom lag luam ntawm Cov Khoom Siv Tshuaj Txhuam Hniav nyob hauv Suav teb) thiab muaj cov ntaub ntawv keeb kwm kev nyab xeeb siv. Cov kev ntsuas kev nyab xeeb muaj cai muab cov lus qhia meej txog kev siv:
Txog li 4%hauv yaug- tawm cov khoom.
Txog li 3%nyob rau hauv tawm- ntawm cov khoom rau lub cev.
Txog li 0.01%nyob rau hauv tawm- ntawm cov khoom rau thaj chaw qhov muag.
- Ntiaj teb no Formulation: Rau cov khoom lag luam tsom mus rau kev lag luam thoob ntiaj teb, kev tsim kho nyob rau hauv cov tsim muaj kev nyab xeeb- siv qib, ua cov khoom lag luam kev nyab xeeb zoo, thiab ua raws li cov cai hauv zos (xws li FDA lossis EU EC ua raws) yog cov kauj ruam tseem ceeb.
Xaiv thiab siv Syn-Ake Products
Thaum nrhiav tau zooSyn-Ake khoom, khaws cov ntsiab lus hauv siab:
- Nrhiav lub npe INCI: Tshawb xyuas cov khoom muaj npe rauDIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE. Nws txoj hauj lwm ntawm daim ntawv tuaj yeem muab lub tswv yim ntxhib ntawm nws cov concentration.
- Synergy yog qhov tseem ceeb: Nws feem ntau ua haujlwm zoo tshaj plaws hauv cov qauv ua ke nrog lwm cov tshuaj tiv thaiv- cov khoom xyaw xws limoisturizers, antioxidants (piv txwv li, vitamin C, E), thiabcollagen{0}} txhawb nqa peptides.
- Kev cia siab tiag tiag: Raws li cov khoom siv tshuaj pleev ib ce, nws muaj aib ntus, tsis yog{0}}kev txhim khonyob rau hauv cov tsos ntawm dynamic wrinkles. Kev sib raug zoo yog qhov tseem ceeb- siv txhua hnub raws li ib feem ntawm kev ua haujlwm thaum sawv ntxov lossis yav tsaus ntuj yog pom zoo kom tau txais txiaj ntsig zoo tshaj plaws.
- Patch Test: Raws li nrog rau txhua yam khoom tu tawv nqaij tshiab, kev kuaj patch raug pom zoo los kuaj xyuas tus kheej rhiab heev.
Cov lus nug nquag
Q: Puas yog Syn-Ake tib yam li Botox?
A: Tsis yog. Txawm hais tias ob qho tib si tuaj yeem txo cov leeg nqaij -raws li wrinkles, lawv cov txheej txheem sib txawv. Botox (botulinum toxin) yog ib qho neurotoxic protein uas yuav tsum tau txhaj tshuaj thiab tiv thaiv kev tso tawm ntawm lub teeb liab kom cog lus. Topical Syn-Ake yog peptide uas ua haujlwm ntawm cov leeg nqaij receptor. Nws tsis muaj zog, tsis yog - ntxeem tau, thiab nws cov teebmeem yog thim rov qab nrog kev siv tsis txuas ntxiv.
Q: Puas muaj kev phiv tshuaj?
A: Thaum tsim nyob rau hauv cov tshuaj pleev ib ce uas pom zoo, nws yog feem ntau zoo - zam. Txhua yam tshuaj pleev ib ce muaj peev xwm ua rau khaus khaus rau cov tib neeg rhiab heev, uas yog vim li cas qhov kev ntsuam xyuas thaj yog qhia.
Q: Nws siv sijhawm ntev npaum li cas thiaj pom cov txiaj ntsig?
A: Qee cov neeg siv yuav pom tias muaj txiaj ntsig zoo nrog kev siv txuas ntxiv rau ob peb lub lis piam. Feem ntau tus neeg muag khoom- tau tshaj tawm cov kev soj ntsuam soj ntsuam ntsuas cov txiaj ntsig tom qab 28 txog 60 hnub ntawm kev siv tsis tu ncua.
Xaus
Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn{0}}Ake) sawv cev rau ib tug fascinating fusion ntawmbiomimicry thiab cosmetic science. Nws muaj kev tshawb fawb hauv av, tshuaj pleev ib ce rau kev hais txog cov cim ntawm kev laus los ntawm kev tsom mus rau ob qho tib si cov leeg nqaij contractions uas ua rau muaj zog wrinkles thiab qee qhov ntawm cov txheej txheem enzymatic ntawm daim tawv nqaij laus.
Los ntawm kev nkag siab txog nws cov txheej txheem, kev nyab xeeb, thiab yuav ua li cas txheeb xyuas nws hauv cov qauv, koj tuaj yeem txiav txim siab paub txog kev siv cov peptide qib siab no rau hauv koj cov kev tu tawv nqaij. Raws li qhov kev thov kom muaj txiaj ntsig zoo, tsis yog- tawm tsam tiv thaiv- cov tshuaj tiv thaiv kev laus zuj zus, Syn-Ake tseem ua kom ruaj khov rau nws qhov chaw raws li cov cuab yeej muaj txiaj ntsig hauv kev tshawb fawb tshuaj pleev ib ce niaj hnub.
Cov ntaub ntawv
- Gok, B., Budama-Kilinc, Y., & Kecel-Gunduz, S. (2023). Anti-kev ua haujlwm ntawm Syn-Ake peptide los ntawm kev ua silico thiab hauv vitro xeem.Phau ntawv Journal of Biomolecular Structure thiab Dynamics.
- Ib qho luv luv, tiv thaiv pab pawg dawb, kev sib txuas ntawm cov tshuaj tiv thaiv -wrinkle venom analogue Syn-Ake® siv qhov ua kom zoo dua Hofmann- hom kev hloov kho. (2014).Tetrahedron Cov ntawv.
- Synthesis thiab Anti-wrinkle Efficacy ntawm Botox-zoo li Polypeptide. (2017).Herald ntawm Tshuaj.