Puas yog Pterostilbene Powder zoo dua li resveratrol?

Product Description

Pterostilbene hmoovRaws li ib tug naturally synthesized compound, Danqi extract yog ib tug trans-stilbene compound, uas yog ib tug methylated derivative ntawm resveratrol. Nws muaj txiaj ntsig thiab kev ua tau zoo yog ntau dua li resveratrol, thiab nws ruaj khov dua li resveratrol.

Qhov laj thawj tseem ceeb ntawm Alzheimer's tus kab mob yog qhov sib txuam ntawm cov protein, uas ua rau cov khoom sib txuam thiab kev tuag ntawm cov hlab ntsha hlwb, yog li ua rau kev paub tsis meej. Tam sim no, cov tshuaj tseem ceeb rau kev kho tus kab mob no yog yav tas los kho tshuaj stilbenes.

Rosedalus radix extract tuaj yeem coagulate lub paj hlwb, pab ua kom pom tseeb, zoo tiv thaiv cov hlab ntsha hauv kev txhawb nqa ntawm cov npoj yaig, tuaj yeem pab lub cev nws tus kheej kom ua tiav cov induction ntawm inhibitory cell kev ua, cov nyhuv inhibitory zoo dua li resveratrol, curcumin thiab lwm yam tshuaj. ua haujlwm zoo dua. Relieve Alzheimer's syndrome, txhim kho lub hlwb lub paj hlwb, txhawb kev puas siab puas ntsws, qeeb laus thiab qaug zog.

Muaj nuj nqi

Ntuj antioxidants pterostilbene yog suav hais tias yog lub ntuj muaj zog antioxidant, feem ntau tshwm sim hauv:

1. Txo oxidative kev nyuaj siab thiab reactiveoxygenspecies (ROS), xws li hydrogen peroxide (H2O2) thiab superoxide anion (O2);

2. Kev qhia ntawm catalase nyob rau hauv cov kab sib txawv ntawm tes nce, xws li tag nrho glutathione, glutathione peroxidase, glutathione reductase, superoxidedismutase (SOD), thiab lwm yam. Nws muaj peev xwm hais tias cov tshuaj tiv thaiv kab mob ntawm pterostilbene tuaj yeem qhib DCOⅱ oxidase los ntawm cov protein kinase C. los txhawb cov neutrophils kom tsis txhob tsim cov superoxide superoxide anion thiab myeloperoxidase, thiab cov nyhuv txo qis ntawm 100μmol / L. Yog li ntawd, cov nyhuv ntawm tej zaum yuav yog koob tshuaj.

3. Daim tawv nqaij photodamage Ntau dhau ntawm ultraviolet (UV) hluav taws xob tuaj yeem tsim ntau hom pa oxygen reactive, rhuav tshem lub cev tiv thaiv kab mob, thiab ua rau cov tawv nqaij mob photodamage, laus thiab txawm qog. Cov kev tshawb fawb tam sim no tau pom tias cov txheej txheem ntawm UVB induced daim tawv nqaij photodamage yog complex, uas tej zaum yuav muaj feem xyuam rau oxidative kev nyuaj siab puas los ntawm kev tsim ROS, xws li superoxide anions, hydroxyl radicals thiab hydrogen peroxide.

4. Resveratrol, cov analogue ntawm Zitan Qi, tau ua pov thawj los txo cov kev mob tshwm sim xws li tawv nqaij erythematous thiab edema tshwm sim los ntawm UV thiab txo qhov tsim ntawm tshav kub kub. Cov teebmeem ntawm Zidanqi ntawm SKH-1 cov nas tsis muaj plaub hau nyob rau hauv mob hnyav thiab mob ntev UVB tau pom tias Zidanqi muaj kev tiv thaiv ntawm UVB (360mJ / cm2) kev puas tsuaj, xws li tawv nqaij tawv, liab, tawv nqaij wrinkles thiab kev laus cuam tshuam txog kev yees duab.

5.Policosanol hmoovtuaj yeem tiv thaiv cov tawv nqaij los ntawm UVB ntev (180mJ / cm2, 3 zaug / lub lis piam, kav ntev li 6 lub hlis), thaum resveratrol hauv kev sim tswj tsis muaj qhov zoo li no. Nws tau kwv yees tias Zitan Qi tuav lub peev xwm tiv thaiv antioxidant ntawm daim tawv nqaij los ntawm kev tswj cov ntsiab lus ntawm glutathione, cov dej num ntawm catalase, superoxide thiab glutathione peroxidase, thiab inhibits UVB induced oxidative puas tsuaj los ntawm kev siv 8-hydroxy-2 '-deoxyguanosine, protein carbonyl thiab isoprost li biomarkers.

Txoj kev ntawm synthesis

Siv 3, 5-dimethoxybenzoic acid thiab p-hydroxybenzaldehyde ua cov ntaub ntawv tseem ceeb, pterostilbene tau npaj los ntawm kev txo qis, chlorination, Arbuzov rearrangement thiab Witting-Horner cov tshuaj tiv thaiv

Synthesis ntawm 3, 5-dimethoxy-benzyl cawv (1) Hauv 150mL peb-txoj kev hwj, 40mL tetrahydrofuran thiab 4.0g (0.1mol) sodium borohydride tau txuas ntxiv nyob rau hauv cov dej khov da dej, thiab cov magnetic agitator tau pib.

Tom qab ntawd 7.29g (0.04mol) ntawm cov khoom siv raw 3, 5-dimethoxybenzoic acid tau maj mam ntxiv, thiab tom qab nplawm rau 30min, 10mL ntawm tetrahydrofuran tov ntawm 2.64mL concentrated sulfuric acid tau maj mam ntxiv, uas tau ua tiav hauv 1h. Tshem tawm cov dej khov da dej thiab hnov ​​​​mob ntawm chav tsev kub. TLC saib xyuas (EA: roj av ether =1∶4) tom qab cov khoom siv raw cov tshuaj tiv thaiv, maj mam ntxiv 5mL methanol, ces ntxiv 2.0mol/L sodium hydroxide tov 50mL, cua sov rau 90 degree rau 2h, txias rau chav tsev kub. Nws tau muab rho tawm nrog ethyl acetate (50mL × 3), ua ke nrog cov organic theem, ntxuav nrog dej distilled (50mL × 3), qhuav nrog anhydrous sulfuric acid, thiab cov kuab tshuaj raug tshem tawm nyob rau hauv siab kom tau cov khoom coarse dawb. Cov khoom siv raw yog recrystallized nrog ethanol / dej los tsim cov dawb acicular crystals.

Synthesis ntawm 3, 5-dimethoxy-benzyl chloride (2) Hauv 150mL peb-txoj raj mis, 30mL DMF (N, n-dimethylformamide), 3.02g (0.018mol) ntawm 3, { {13}}dimethoxy-benzyl cawv thiab 3mL ntawm triethylamine tau ntxiv rau hauv qab da dej khov. Tom qab qhov kev daws teeb meem tau pom meej, cov hlau nplaum sib nqus tau qhib. Maj mam ntxiv 3mL DMF tov ntawm dichlorosulfoxide. Tom qab dripping, cov dej khov tau muab tshem tawm thiab cov tshuaj tiv thaiv tau ua nyob rau hauv chav tsev kub. TLC tau saib xyuas cov txheej txheem tshuaj tiv thaiv (EA∶ roj av ether =1∶10). Tom qab cov tshuaj tiv thaiv tiav (kwv yees li 5 teev), cov tshuaj tiv thaiv yog nchuav rau hauv cov dej khov sib tov thiab sawv ntsug rau 2 teev. Cov khoom dawb tau lim, cov roj av ethanol / dej yog recrystallized, thiab cov anhydrous sodium sulfate tau qhuav rau lub teeb daj.

3, 5 - dimethoxy phenyl methoxy phosphonic acid diethyl ester (3) cov synthesis ntawm 2.94 g (0.0158 mol) 3, 5 - dimethoxy benzyl chloride thiab 5.5 mL (0.0315 mol), diethyl phosphite muab tso rau hauv peb lub khob, rhuab mus rau 140 degree cov tshuaj tiv thaiv ntawm 5 h tom qab txias rau hauv chav tsev kub, lub tshuab nqus tsev distillation kom tshem tawm ntau tshaj ntawm diethyl phosphite, Ib tug txiv kab ntxwv-liab oily khoom yog tsim.

Synthesis ntawm {{{{10}}}}}(tetrahydro-2h-pyran-2-oxygen) benzaldehyde (4) hauv 150mL peb-txoj kev hwj, 30mL dichloromethane, 2.94g (0.0236mol) p-hydroxybenzaldehyde, 0.61g (0.00236mol) p-toluene sulfonate pyridohum ntsev tau ntxiv nyob rau hauv ntu hauv qab da dej khov. Maj mam ntxiv 3.3mL (0.00236mol) ntawm dichloromethane kua ntawm dihydropyran. Tom qab qhov sib ntxiv, cov dej khov nab kuab tau muab tshem tawm thiab qhov kub thiab txias tau muab tso rau hauv chav sov. Tom qab TLC soj ntsuam cov tshuaj tiv thaiv (EA: roj av ether =1∶5) tau ua tiav (kwv yees li 3h), methylene chloride tau siv rau kev rho tawm (50mL × 3) thiab theem organic tau ua ke. Tom qab ntxuav nrog 50mL sodium hydroxide tov, 5% dilute hydrochloric acid thiab dej distilled nyob rau hauv lem, anhydrous sodium sulfate tau qhuav thiab decompressive distillation yog ua rau lub teeb daj kua.

Ntxiv 20mLDMF thiab 0.45g (0.008mol) sodium methanol rau hauv cov roj sib tov, do rau 30min, poob 20mLDMF tov ntawm 3.25g (0.0158mol)4' -tetrahydropyran benzaldehyde nyob rau hauv dej khov da dej, thiab tom qab ntawd kub txog 100 degree rau 1h cov tshuaj tiv thaiv. Txias rau hauv chav tsev kub thiab ua rau ib hmos. Ncuav cov tshuaj tiv thaiv rau hauv 200mL dej khov dej, kho tus nqi pH ntawm cov tshuaj rau 4-5 nrog cov concentrated hydrochloric acid, thiab do ntawm chav tsev kub rau 6h. Extract nrog ethyl acetate (50mL × 3), muab cov organic theem, ntxuav nrog distilled dej (50mL × 3), txo siab thiab tshem tawm cov hnyav kom tau cov roj crude khoom, ethanol recrystallization khoom pterostilbene.

Yuav tiv tauj peb li cas?

Peb yog ib lub tuam txhab nrog ntau xyoo ntawm kev muag khoom nyob rau hauv cov nroj tsuag extract kev lag luam. Tom qab xyoo ntawm kev ua haujlwm, peb muaj ntau yam khoom, xws li txiv hmab txiv ntoo thiab zaub hmoov, tshuaj pleev ib ce, ntsiav tshuaj khoom qab zib thiab lwm yam khoom. Peb yog cov kws tshaj lij cov khoom siv raw khoom. Tam sim no, peb lub tuam txhab muag khoom pheej yigPterostilbene hmoov,uas yog dav siv hauv cov khoom kho mob, tshuaj, tshuaj pleev ib ce thiab lwm yam. Cov uas yuav tsum tau ua cov khoom kho mob tuaj yeem yuav cov khoom siv raw no. Nyob rau tib lub sijhawm, txij li peb cov khoom raug muag ncaj qha los ntawm cov chaw tsim khoom, peb tuaj yeem lav qhov zoo thiab yuav nrog kev ntseeg siab.

Yog tias koj xav yuav lossis txaus siab rau nws, koj tuaj yeem xa email rau peb qhov chaw ua haujlwm emailella.zhang@huilinbio-tech.com iblos ntawm lub vev xaib thoob ntiaj teb. Peb yuav teb koj sai li sai tau thaum koj pom cov lus. Tsis tas li ntawd, koj tuaj yeem mus saib qhov chaw offline. Peb lub tuam txhab nyob hauv Chav 706, Tsev B, Fengze Science Park, No. 170, West Street, Yanta District, Xi 'an City, Shaanxi Province. Zoo siab txais tos koj tuaj xyuas