Nkag siab retatrutide cov txiaj ntsig hauv kev tshawb fawb metabolic
Rov qab ua retatrutidetau tshwm sim los ua qhov sib txuas ntawm cov kev nyiam tseem ceeb hauv kev sib tw metabolic vim nws qhov triple triple - rov ua tshuab ua tshuab. Tsab ntawv no yuav tshuaj xyuas cov ntaub ntawv muaj kev tshawb fawb ntawm chaw kuaj mob, tsom mus saib cov kev soj ntsuam ntawm kev noj qab haus huv yam tsis ua kev noj qab haus huv.
Cov Kev Tshawb Nrhiav Tseem Ceeb Tshawb nrhiav los ntawm kev sim tshuaj ntsuam
Theem 2 Cov chaw tshawb nrhiav tshawb fawb no luam tawm ua cov ntawv xov xwm kho mob tau tshaj tawm cov kev soj ntsuam ntau yam kev ua haujlwm metabolic[1]:
- 24-Lub lim tiam cov ntaub ntawv qhia txog 14-17% kev txo ntawm kev kawm hauv kev kawm
- 48-lub limtiam kev tshawb fawb pom tau pom tias muaj kev cuam tshuam metabolic
- Tseem ceeb txhim kho hauv metabolic tsis tau pom
- Lub siab nyiam Lipid cov ntaub ntawv hloov pauv tau sau tseg hauv kev kawm cov neeg
Cov teebmeem no tau pom nyob rau hauv cov kev tswj hwm nrog kev saib xyuas kev saib xyuas kev saib xyuas thiab tshuaj xyuas kev saib xyuas.
Kev tshawb fawb txog kev hloov pauv ntawm lub cev ntawm lub cev
Cov lus nug ntawmRetatrutide cov txiaj ntsig kev ua haujlwm ntawm lub cevTau sib tham hauv cov ntsiab lus tshawb fawb, txawm tias feem ntau yog nyob rau hauv kev sib piv rau nws pom tshwm sim ntawm lub cev muaj ntau dua li kev ua kis las. Kev tshawb fawb tau sau tseg[2]:
- Kev khaws cia ntawm cov nqaij ntshiv loj thaum lub cev tseem ceeb txo
- 92-95% ntawm kev poob phaus los ntawm cov rog loj hauv cov chaw kuaj mob
- Txhim kho cov leeg nqaij - rau - rog rog rog hauv kev kawm cov neeg tuaj koom
- Txhim kho cov metabolic efficiency thaum caloric txwv
Cov kev soj ntsuam no tau tsim kev txaus siab ntawm cov kws tshawb fawb tab tom hloov lub cev ntawm lub cev hloov, txawm tias txhua cov ntaub ntawv los ntawm kev kuaj mob ntau dua li kis las.
Poj niam ntsuag -} kev pom zoo
Tshawb nrhiav rau hauv tej peev xwmRevatrutide cov txiaj ntsig rau cov txiv neejtau tshaj tawm qee tus tub los ntxhais -} kev soj ntsuam hauv chaw kuaj mob[3]:
- Cov neeg koom nrog cov txiv neej uas tau qhia me ntsis cov lus teb ntau dua hauv cov nqi metabolic
- Cov Poj Niam Sib Txawv Hauv Sab Zoo Tshaj Tawm Cov Khoom Tshwj Xeeb
- Cov qauv kev ua tau zoo sib xws hla cov tub los ntxhais
- Sib piv kev ceev ceev ntawm cov nqaij ntshiv hauv cov txiv neej thiab poj niam koom nrog
Cov kev tshawb pom no qhia kom zoo sib xws thoob plaws cov tub rog nrog kev sib txawv me me hauv cov lus teb.
Mechanism ntawm kev nqis tes ua
Retatrutide cov triple triple - kev txiav txim siab mechanism paub qhov txawv thiab dual agononists hauv kev tshawb fawb metabolic[4]:
- Ua kom ib txhij qhib ntawm gip, glp-1, thiab gluucaging receptors
- Txhim kho cov kev soj ntsuam metabolic tau hauv chaw kuaj mob
- Ntshaw kev cai los ntawm kev tswj hwm thiab cov txheej txheem sib luag
- Txhim kho cov insulin rhiab cim cov cim hauv kev kawm cov neeg koom
Qhov ntau {- phiaj ua ke kom sawv cev rau qhov kev loj hlob tseem ceeb hauv kev tshawb fawb hauv metagolic.
Soj ntsuam sim
Cov kev tshawb fawb tsis ntev los no tau sau ntau qhov tseem ceeb ntawm kev rov ua haujlwm ntawm cov teebmeem[5]:
| Chaw ua uas tsis tau haus | 24-Lub Limtiam Ntsiab | 48-lub lim tiam yeej |
|---|---|---|
| Lub cev txo | 14-17% | 22-24% |
| Txoj sia ncig | -10.2 cm | -15.7 cm |
| Systolic bp | -6.5 hli | -8.1 mmHg |
| Cov Cholestery HDL | +6.2 mg / dl | +8.4 mg / dl |
Source: Theem 2 Kho Mob Sim[1]
Kev Nyab Xeeb thiab Ua Kom Tau Profile
Cov kev sim khomob tau muab cov ntaub ntawv qhia dav dav ntawm kev rov ua haujlwm ntawm kev nyab xeeb profile[6]:
- Cov xwm txheej feem ntau yog tus mob me me mus rau qhov hnyav hauv qhov hnyav
- Kev kub plab tau tshwm sim feem ntau (xeev siab, raws plab, ntuav)
- DiscontinThov kev hloov pauv vim yog cov kev mob tshwm sim tau tsawg (4-7%)
- Tsis muaj lub cim rau kev nyab xeeb rau thaum lub sijhawm sim
Cov kev tshawb pom no txhawb kev tshawb nrhiav txuas ntxiv mus rau hauv kev rov ua haujlwm ntawm cov txheej txheem thiab cov ntawv thov yuav.
Kev tsom xam piv nrog cov tebchaw uas twb muaj lawm
Tshawb nrhiav kev sib piv pom tau hais tseg retatrutide cov nta txawv[7]:
- Ntau dua kev ua tau zoo nyob rau hauv lub cev loj txo qhov piv rau ib leeg agonists
- Kev Nyab Xeeb Kev Nyab Xeeb los tsim cov tebchaw
- Cov Txiaj Ntsig Me Ntxub Nyiaj Txiag vim muaj triple - Cov kev ua haujlwm
- Muaj peev xwm rau cov ntawv thov metabolic
Kev Tshawb Fawb Yav Tom Ntej
Kev kawm txuas ntxiv thiab npaj tau npaj[8]:
- Ntev dua - lus tshwm sim tshwm sim dhau 48 lub lis piam
- Ua ke nrog lwm cov teeb meem metabolic
- Cov neeg feem tshwj xeeb pawg txheeb xyuas
- Kev kawm siv tshuab kev kawm kom nkag siab zoo dua Triple -} agonist cuam tshuam
Tag
Kev tshawb nrhiav tam sim no rauRov qab cov kev pab nyiaj rov qabqhia ib qho kev sib txuas nrog cov peev xwm tseem ceeb hauv kev tshawb fawb metabolic. Nws qhov kev sib tw tshiab triple {{1} Cov tshuab ua kom muaj kev txhim kho me nyuam yaus sawv cev rau kev kawm metabolic. Thaum cov chaw kuaj sim tau qhia cov ntsiab lus muaj txiaj ntsig thiab kev tshawb fawb ntawm lub cev yog qhov xav tau los nkag siab nws ntev}} kev sib txuam thiab cov ntawv thov yuav.
Rau cov kws tshawb nrhiav txaus siab rau cov kev ntsuas metabolic, cov kev tshawb pom no nthuav dav ntawm cov tshuaj hormonal thiab qhia cov kev xaiv ua kom zoo sib xws los ntawm cov tebchaw.
Phau ntawv
[1] Tshiab England Journal ofment of Tshuaj {}}}}}}}}}}}}} illion 2 Kev Ua Haujlwm (2023)
[2] Phau Ntawv Xov Xwm ntawm Chaw Kho Mob endocrminology thiab metabolism -} Lub Cev Kev Ntsuas Kev Ntsuam Xyuas
[3] Qib Ntshav Qab Zib & Xaus - poj niam txiv neej -}}}}}}}}} cov txiaj ntsig tshwj xeeb
[4] Xwm Xyuas Xyuas Endocrinology Technology -} mechanism ntawm kev nqis tes ua
[5] JAMA NETWORK QHIB -} ntev txuas cov ntaub ntawv sim
[6] cov chaw kho mob & kho cov chaw muag tshuaj & kho cov - kev tiv thaiv kev nyab xeeb profile
[7] Kev mob ntshav qab zib - kev tshawb fawb zoo
[8] Yav Tom Ntej Tshuaj Lim Lim-}} Kev Tshawb Fawb Kev Tshawb Nrhiav
Kev tsis lees paub
Cov lus no tham txog cov kev tshawb fawb tshawb fawb rau cov ntsiab lus nkaus xwb. Nws tsis yog cov lus qhia txog kev kho mob, cov khoom lag luam, lossis kev pom zoo rau kev siv. Cov ntaub ntawv ntawm retatrutide yog nyob ntawm chaw kuaj mob cov ntaub ntawv thiab yuav tsum tsis txhob txhais raws li kev txhawb nqa cov txiaj ntsig kev noj qab haus huv tshwj xeeb. Tsob nroj - derived compounds tau hais txog rau cov ntsiab lus tshawb fawb tsuas yog tsis muaj kev lees paub ntawm kev ua tau zoo.