Yog tias koj puas tau xav paub txog cov nroj tsuag ntuj uas cov kws tshawb fawb tab tom kawm txog kev noj qab haus huv ntawm lub plawv thiab lub hlwb, koj yuav xav kawm txogscutellarin. Nws yog lub qhov ncauj hais, tab sis qhov me me molecule no ntsiag to ua nthwv dej loj hauv kev tshawb fawb kho mob thoob plaws ntiaj teb. Hauv phau ntawv qhia no, peb yuav taug kev los ntawm scutellarin yog dab tsi, nws tuaj yeem ua li cas rau koj lub cev, yuav ua li cas coj nws kom nyab xeeb, thiab seb puas muaj kev phiv tshwm sim.
Dab tsi yog Scutellarin?
Hauv nws qhov tseem ceeb,scutellarin(tseem hu ua scutellarein-7-O-glucuronide los yog breviscapine) yog ib hom tshuajflavonoid- tib tsev neeg ntawm cov tshuaj tiv thaiv antioxidants pom hauv cov txiv hmab txiv ntoo, zaub, thiab tshuaj yej. Tshwj xeeb tshaj yog, scutellarin yog aflavonoid glucuronide, txhais tau tias nws yog flavonoid txuas rau cov suab thaj -zoo li molecule hu ua glucuronic acid. Nws cov mis molecular yog C₂₁H₁₈O₁₂, nrog rau qhov hnyav molecular txog 462 grams ib mole.
Scutellarin tshwm sim nyob rau hauv ntau yam tshuaj ntsuab tshuaj ntsuab. Ob qhov chaw tshaj plaws yogScutellaria barbata(qee zaum hu ua barbed skullcap) thiabErigeron breviscapus: 3 lab tus kiv cua tos koj rau Webtalk!(ib qho tshuaj ntsuab siv hauv thaj chaw ntawm Tuam Tshoj rau ntau pua xyoo). Hauv kev coj noj coj ua, Erigeron breviscapus tau siv ntev los pab kho mob stroke thiab mob pob qij txha. Niaj hnub no, cov thev naus laus zis rho tawm niaj hnub zoo li siab -kev ua haujlwm ua kua chromatography (HPLC) ua rau nws muaj peev xwm cais cov scutellarin hmoov rau kev tshawb fawb thiab kev siv ntxiv.
Cov txiaj ntsig ntawm Scutellarin yog dab tsi?
Yog vim li cas cov kws tshawb fawb tau zoo siab heev txog scutellarin yog tias nws ua haujlwm los ntawm ntau txoj hauv kev tiv thaiv hauv lub cev txhua lub sijhawm. Nov yog cov txiaj ntsig zoo tshaj plaws - kawm.
Lub paj hlwb thiab paj hlwb tiv thaiv
Scutellarin tau pom qhov tseem ceebcov teebmeem neuroprotectivehauv ntau qhov kev tshawb fawb. Hauv cov qauv tsiaj, nws pab txo qis kev puas hlwb tom qab mob stroke los ntawm kev txo qis kev mob, txwv tsis pub oxidative kev nyuaj siab, thiab tiv thaiv cov paj hlwb tuag. Ib txoj kev tshawb fawb 2025 ntawm ntau yam kab mob sclerosis zoo li pom tias scutellarin kho cov kab mob myelin puas (cov txheej txheem tiv thaiv ib puag ncig cov paj hlwb) los ntawm kev txo qis ntawm cov kab mob oxygen reactive thiab thaiv cov kab mob ntawm lub hlwb tiv thaiv kab mob. Tib txoj kev tshawb fawb kuj tau tshaj tawm tias scutellarin tuaj yeem ua kom cov permeability nce ntxivntshav-hlwb barrier, uas ib txwm khaws ntau cov tshuaj tawm ntawm lub hlwb, qhia tias nws yuav pab tau lwm yam tshuaj mus txog lub hlwb kom zoo dua.
Lub plawv thiab hlab plawv
Ib qho kev tshuaj xyuas 2024 tau xaus lus tias scutellarin muaj ntau yam txiaj ntsig rau cov kab mob plawv, suav nrog kev tiv thaiv myocardial fibrosis (tiv thaiv cov leeg mob plawv), tiv thaiv cov hlab ntsha hauv cov hlab ntsha, txo qis kev raug mob plawv, thiab kev txhim kho tag nrho hauv lub plawv. Cov kev tshawb fawb ntxiv qhia tau hais tias scutellarin pab txo cov hlab ntsha, txo cov ntshav txhaws, thiab tiv thaiv lub plawv cov leeg tiv thaiv kev puas tsuaj thaum cov ntshav ntws rov qab los tom qab kev thaiv ib ntus.
Anti-Inflammatory zog
Cov kab mob ntev yog nyob ntawm cov hauv paus hniav ntawm ntau yam kab mob, los ntawm kev mob caj dab mus rau ntshav qab zib. Scutellarin tau pom tias yuav ua rau mob o los ntawm kev txwv txoj hauv kev tseem ceeb hauv lub hlwb, suav nrog PI3K / Akt, MAPK, thiab NF-κB. Nyob rau tib lub sijhawm, nws ua rau lub cev muaj zog tiv thaiv kab mob antioxidant los ntawm Nrf2 txoj hauv kev. Qhov kev ua ob no pab tiv thaiv cov ntaub so ntswg los ntawm ob qho tib si nplaim taws ntawm qhov mob thiab qhov hnyav ntawm oxidative kev nyuaj siab.
Lwm Cov Kev Pab Thaum Muaj Xwm Ceev
Cov kws tshawb fawb tseem tab tom saib scutellarin rau nwstshuaj tiv thaiv qogmuaj peev xwm (tshwj xeeb tshaj yog nyob rau hauv txoj hnyuv, lub mis, thiab mob ntsws cancer),tiv thaiv raum, kev kho mob ntawmkab mob metabolic, tshuaj tiv thaiv kab mob, thiab txawm tias pob txha noj qab haus huv - qhov twg cov kev tshawb fawb thaum ntxov qhia tias nws tuaj yeem txhawb kev ua haujlwm ntawm cov pob txha tsim hlwb hu ua osteoblasts.
Scutellarin ua haujlwm li cas?
Scutellarin belongs rau ib chav kawm ntawm cov tshuaj hu uaflavonoids. Xav txog cov flavonoids uas yog lub cev pab lub cev - lawv ua zoo li cov neeg kho me me uas taug kev ncig, tso cov hluav taws me me (kev puas tsuaj oxidation) thiab ua kom kub kub (mob). Dab tsi ua rau scutellarin tshwj xeeb yog tias nws tsis yog ua ib txoj haujlwm xwb. Nws hits ntau lub hom phiaj, zoo ib yam li yuav ua li cas ib tus yuam sij yuav qhib ob peb yam cuam tshuam. Qhov no ntau lub hom phiaj yog vim li cas cov kws tshawb fawb hu nws ua "multi-tasking" molecule thiab yog vim li cas nws qhia tau hais tias kev cog lus rau cov kab mob nyuaj uas cuam tshuam nrog ntau yam teeb meem ib zaug.
Puas yog Scutellarin Safe? Cov Kev Phem Txhaum Cai Thiab Kev Siv Tshuaj
Zuag qhia tag nrho, scutellarin yog suav tias yog kev nyab xeeb heev, tshwj xeeb tshaj yog thaum siv raws li qhia. Txawm li cas los xij, muaj ob peb yam tsim nyog paub ua ntej noj nws.
- Tsawg Bioavailability- Ib qho teeb meem ntawm scutellarin yog tias nws tsis nqus zoo heev thaum noj los ntawm qhov ncauj. Tib neeg kev tshawb fawb tau pom tias covqhov ncauj bioavailabilityntawm scutellarin nyob ib ncig ntawm10.67%, txhais tau hais tias tsuas yog ib feem kaum ntawm qhov koj nqos tau mus txog koj cov hlab ntsha. Qhov kev nqus qis no yog ib feem vim tias scutellarin tsis yaj yooj yim hauv dej. Yuav kom tau txais ib ncig ntawm qhov no, qee cov tuam ntxhab siv cov tshuab xa khoom tshwj xeeb, thiab qee qhov kev tshawb fawb siv cov tshuaj es tsis yog tshuaj rau qhov ncauj.
- Feem ntau Zoo Tolerability- Hauv kev tshawb fawb soj ntsuam, scutellarin tau txais txiaj ntsig zoo nrog qee qhov kev mob tshwm sim. Ib txoj kev tshawb fawb txog kev tiv thaiv kab mob qog noj ntshav ntawm scutellarin tau sau tseg tias tsis muaj kev phom sij hauv cov ntshav lossis daim siab ntawm cov tsiaj kho.
- Muaj Kev Sib Tham Tshuaj- Feem ntau cov kev tshawb fawb qhia tias scutellarin yogtsis zoo li yuav ua rau muaj kev cuam tshuam loj ntawm tshuaj ntsuab-tshuajnrog cov tshuaj nquag ua tiav los ntawm tsev neeg tseem ceeb ntawm lub siab enzymes (CYP450 tsev neeg). Uas tau hais tias, ib txoj kev tshawb fawb ntawm nas tau qhia tias scutellarin tuaj yeem ua rau tsis muaj zog tiv thaiv ib qho enzyme hu uaCYP1A2, uas rhuav tshem qee cov tshuaj xws li theophylline (ib qho tshuaj tiv thaiv mob hawb pob) thiab clopidogrel (cov ntshav thinner). Lwm txoj kev tshawb fawb ntawm nas pom tias scutellarin tuaj yeem cuam tshuam li cas clopidogrel metabolized, yog li cov neeg noj.cov tshuaj noj ntshavyuav tsum tau ceev faj thiab sab laj nrog kws kho mob ua ntej ntxiv scutellarin.
- Mob siab los ntawm Cov Tshuaj Txhuam Hniav?- Qee lwm hom pob txha taub hau tau txuas nrog rau qhov tsis tshua muaj mob ntawm daim siab mob, txawm tias yuav luag txhua zaus ua ke nrog lwm cov tshuaj ntsuab. Tsis muaj cov ntaub ntawv qhia meej ncaj qha txuas ncaj qha rau cov ntshiab scutellarin nws tus kheej rau daim siab puas tsuaj, tab sis nrog rau cov tshuaj ntxiv, nws yog ib qho tsim nyog yuav tsum tau ua raws li cov tshuaj pom zoo thiab tsis txhob sib xyaw nrog lwm cov tshuaj ntsuab hauv siab tshwj tsis yog saib xyuas los ntawm tus kws tshaj lij.
Dab tsi yog qhov koob tshuaj ntawm Scutellarin?
Vim tias feem ntau tib neeg cov kev tshawb fawb tau siv cov ntawv txhaj tshuaj ntawm scutellarin es tsis yog tshuaj rau qhov ncauj, tsis muaj kev pom zoo thoob ntiaj teb-raws li qhov ncauj noj rau kev siv dav dav. Yog tias koj tab tom txiav txim siab noj scutellarin ntxiv, nco ntsoov ua raws lipab tswv yimmuab rau ntawm daim ntawv lo los ntawm cov chaw tsim khoom. Cov khoom sib txawv tuaj yeem muaj qib purity sib txawv (feem ntau 80-98% scutellarin) thiab kev txhim kho bioavailability sib txawv, yog li cov lus qhia daim ntawv lo yuav tsum yog koj thawj phau ntawv qhia.
Nws kuj txawj ntsenrog tus kws kho mob thamua ntej ntxiv cov tshuaj ntxiv rau koj li niaj zaus, tshwj xeeb tshaj yog tias koj muaj mob ua ntej lossis noj lwm yam tshuaj. Tus kws kho mob lossis tus kws muag tshuaj tuaj yeem pab koj txiav txim siab seb scutellarin puas tsim nyog rau koj thiab seb tus nqi pib zoo npaum li cas yuav yog nyob ntawm koj tus kheej txoj kev noj qab haus huv.
Rau cov kws tshawb fawb thiab cov kws tsim qauv ua haujlwm nrog cov hmoov dawb huv scutellarin, ntau npaum li cas yuav nyob ntawm tag nrho ntawm daim ntawv thov (kev tshawb fawb hauv vitro, tsiaj qauv, lossis kev tsim khoom). Hauv cov xwm txheej no, xa mus rau cov txheej txheem kev tshawb fawb luam tawm lossis ua koj tus kheej cov kev ntsuas kev nyab xeeb me me ua ntej nce qib.
Kab hauv qab
Scutellarinyog lub ntuj flavonoid ntxim nyiam nrog kev tshawb fawb raug cai tom qab nws cov txiaj ntsig zoo - tshwj xeeb tshaj yog rau lub hlwb, lub plawv, thiab kev noj qab haus huv. Txawm hais tias nws tseem muaj ntau dua hauv cov chaw tshawb fawb ntau dua li ntawm cov khw muag khoom ntxiv, cov pov thawj tseem tab tom tsim. Rau cov kws tshawb fawb, cov kws tsim qauv, thiab cov tsim khoom tsim khoom, ua haujlwm nrog cov hmoov purity scutellarin los ntawm cov chaw muag khoom muaj koob npe ua kom cov txiaj ntsig zoo ib yam, txhim khu kev ntseeg - seb puas yog rau kev tshawb fawb hauv vitro, kev tshawb fawb tsiaj, lossis kev tsim cov khoom noj qab haus huv tshiab. Raws li kev tshawb fawb tau ua tiav, cov nroj tsuag txo qis no yuav muaj ib hnub dhau los ua lub npe paub hauv kev noj qab haus huv txhua hnub.