Product Description
Genistein hmoovyog planchisoflavin, cov khoom no yog cov duab plaub lossis hexagonal rod-puab crystallization (60 feem pua ethanol), dendritic crystallization (ether), melting point 297-298 degree (me ntsis decomposed). Soluble nyob rau hauv DMSO thiab ethanol, yuav luag insoluble nyob rau hauv dej, solubility nyob rau hauv dej yog 8.7 MCG / ml, hloov cov tshuaj pH tsis muaj qhov tseem ceeb rau genistein. Genistein, feem ntau muaj nyob rau hauv legumes, xws li locust horn, taum hauv paus ntsiab lus yog loj dua.
Khoom npe | Genistein |
English npe | Genistein |
CAS Nr | 446-72-0 |
Khoom npe | 5,7,4'-trihydroxyl isoflavone genistein Goldfins isoflavone |
Cov mis mos molecular | C15H10O5 |
Molecular hnyav | 270.23 |
Cov ntsiab lus | 98 feem pua |
Kev kuaj xyuas txoj kev | HPLC Cov khoom zoo: lub teeb daj hmoov siv lead ua Lub teeb daj crystalline hmoov; Soluble nyob rau hauv cov organic solvents, soluble nyob rau hauv dilute alkali daj. |
Khoom zoo li | lub teeb daj hmoov siv lead ua |
Cov khoom siv | Rhizome ntawm Genista tinctoria Linn, ib tsob nroj leguminous |
Cov txheej txheem ntau lawm | Cov txheej txheem ntau lawm: feem ntau yog los ntawm kev haus cawv extraction, extraction, crystallization thiab lwm yam txheej txheem tiav |
Txoj kev khaws cia | txias thiab qhuav, zam lub teeb, tsis txhob kub siab |
Txee lub neej | 2 xyoo |
Muaj nuj nqi
1. Genistein thiab kab mob plawv. Genistein ua lub luag haujlwm tseem ceeb hauv kev txo qis qhov tshwm sim ntawm cov kab mob plawv. Cov roj lipoprotein tsawg ntom ntom hauv cov ntshav yog siab thiab yooj yim rau oxidized, uas yuav ua rau atherosclerosis. Genistein tuaj yeem txo cov roj cholesterol, inhibit oxidation ntawm cov roj lipoprotein tsawg ntom ntom (LDL), thiab ua kom LDL qib hauv cov ntshav qis, txhim kho qhov txawv txav peroxidation tshwm sim los ntawm cov roj ntau, thiab txo cov peroxidation puas tsuaj rau lub cev. Genistein tuaj yeem tswj hwm LDL receptor thiab nce kev ua haujlwm ntawm LDL receptor, yog li txhawb kev tshem tawm cov roj cholesterol. Genistein tuaj yeem tiv thaiv kev loj hlob ntawm cov leeg nqaij du, angiogenesis thiab cell adhesion, thiab txo qhov tshwm sim ntawm cov kab mob plawv.
2. Cov nyhuv ntawm genistein ntawm lub paj hlwb. Genistein muaj cov txiaj ntsig ntawm kev txhawb nqa lub paj hlwb rov tsim dua tshiab thiab ua kom lub hlwb tsis nco qab. Raws li kev kho mob niaj hnub no, thaum mob stroke (cerebral hemorrhage) thiab mob stroke (cerebral infarction) tshwm sim, cov kev hloov pauv pathophysiological xws li ischemia thiab hypoxia, degeneration thiab necrosis ntawm lub hlwb cov ntaub so ntswg cuam tshuam nrog kev nkag mus ntawm calcium ions sab nraum lub hlwb. ntawm lub paj hlwb. Lub overload ntawm calcium ions nyob rau hauv lub hlwb hlwb yog ib qho ntawm lub ntsiab ua rau degeneration thiab necrosis ntawm hlwb hlwb. Cov kev tshawb fawb tshiab tau pom tias tom qab hloov txoj hauv kev ntawm kev tswj hwm, genigeniin tuaj yeem hla cov hlab ntsha-hlwb thiab tiv thaiv lub hlwb thaum mob stroke (cerebral hemorrhage) thiab mob stroke (cerebral infarction) los ntawm kev cuam tshuam cov cell membrane Ca ntxiv rau receptor.
 |  |
3. Genistein hmoovmuaj hluav taws xob tiv thaiv.Genistein (genistein), muaj zog inhibitor ntawm cov protein tyrosine kinase kev ua haujlwm uas tseem muaj cov tshuaj tiv thaiv antioxidant thiab cov tshuaj estrogen zoo li, tau txheeb xyuas los ntawm landauer li al., ua haujlwm ntawm US Armed Forces Radiobiological Research Institute (AFRRI) Laboratory, raws li ib tug radiprotectant, Genistein tau txhim kho qhov 30-hnub ciaj sia tus nqi ntawm cov nas raug mob rau lub hlwb raug mob ntawm tag nrho lub cev irradiation koob tshuaj (9.5Gy), los ntawm subcutaneous txhaj 24 teev ua ntej irradiation los yog gavage 4 hnub ua ntej irradiation los yog 4 hnub tom qab irradiation.
4. Genistein thiab menopausal syndrome nyob rau hauv cov poj niam. Genistein muaj cov tshuaj estrogen tsis muaj zog thiab lub luag haujlwm ntawm estrogen. Cov kev tshawb fawb tau pom tias cov poj niam lub cev tsis muaj zog, vim lub zes qe menyuam degeneration, estrogen txo hauv lub cev, cov poj niam yuav tshwm sim cov tsos mob ntawm menopausal syndrome, thiab kev noj cov genistein ntau npaum li cas hauv cov poj niam cev xeeb tub tuaj yeem ntxiv qhov tsis muaj estrogen hauv lub cev, ua lub luag haujlwm hauv tiv thaiv thiab txo cov poj niam menopausal syndrome. Nws tau pom tias cov tshuaj estrogen - zoo li cov nyhuv yuav yog lub hauv paus ntsiab lus ntawm genistein los tiv thaiv osteoporosis.
Txoj kev npaj
Lub solubility ntawm genistein nyob rau hauv dej thiab aqueous daws nrog txawv pH qhov tseem ceeb yog txiav txim los ntawm thermodynamic solubility kev txiav txim txoj kev. Cov teebmeem ntawm Poloxham F-68, sodium dodecyl sulfonate, hydrophilic polymer excipients PEG-6000, PVP K30 thiab hydroxypropyl -cyclodextrin ntawm nws cov solubility raug soj ntsuam.Cov permeability coefficient ntawm genistein raug ntsuas nyob rau hauv cov qauv ntawm cov hnyuv me. ntawm cov nas uas tsis thim rov qab, thiab qhov cuam tshuam ntawm qhov sib txawv ntawm kev txhawb nqa ntawm nws cov permeability tau tshawb xyuas. Cov teebmeem ntawm solubilizing thiab permeating cov neeg ua haujlwm ntawm cov haujlwm ntawm genistein hauv subacute aging nas raug ntxias los ntawm D-galactose tau tshawb xyuas.
Results: The solubility of genistein in water and different pH solutions was less than 18μg·ml-1, and the solubility of genistein was significantly improved by different concentrations of hydroxypropyl -β-cyclodextrin. The permeability coefficient of genistein in the small intestine of rats was 2·36×10-6cm·s-1, and different types of absorption accelerators could increase the permeability coefficient of genistein, and the absorption effect was as follows :0·5% sodium deoxycholate >0·5% sodium dodecyl sulfonate >0·5% ethylenediamine tetraacetate >0·5% Poloxam F-68>0·5% twain 80>0 · 5 feem pua carboxymethyl chitosan. Cov txiaj ntsig hauv vivo cov txiaj ntsig tau pom tias cov kev ua hauv vivo ntawm genistein tom qab solubilization yog qhov txawv ntawm qhov ua ntej solubilization, thiab hauv vivo kev ua ntawm genistein tom qab solubilization thiab permeation yog qhov sib txawv ntawm genistein tsuas yog tom qab solubilization. Xaus: Txhim kho qhov nqus ntawm genistein hauv cov hnyuv me raws li solubility thiab permeability coefficient tuaj yeem txhim kho nws cov kev tiv thaiv kev laus hauv vivo.
Yuav tiv tauj peb li cas?
Peb lub tuam txhab yog cov kws tshaj lij ntawm cov khoom siv raw khoom ib nrab, suav nrog cov nroj tsuag extract, txiv hmab txiv ntoo thiab zaub hmoov, tshuaj pleev ib ce, ntsiav tshuaj khoom qab zib thiab lwm yam khoom; Peb cov khoom tau muab ncaj qha los ntawm cov chaw tsim khoom, yog li tus nqi yog qhov zoo heev, thiab qhov zoo yog lav, yog li koj tuaj yeem so assured mus yuav. Tam sim no, peb lub tuam txhab muag khoom zooGenistein hmoov, uas yog cov khoom siv zoo tshaj plaws hauv cov khoom siv kho mob, tshuaj, khoom tu tawv nqaij thiab lwm yam khoom.
Yog tias koj txaus siab rau cov khoom no thiab xav paub ntau ntxiv txog nws, koj tuaj yeem sab laj nrog peb tus thawj tswj hwm tus account los ntawm thoob ntiaj teb lub vev xaib lossis email, peb tus email chaw nyob yogella.zhang@huilinbio-tech.com ib; Peb lub Hoobkas nyob hauv Chav 706, Tsev B, Fengze Science Park, No.170 West Street, Yanta District, Xi 'an City, Shaanxi Province.