Dab tsi yog metalothionein hmoov? Cov txiaj ntsig & Cov Kev Siv

Raws li tus xa khoom ntawm cov tebchaw nkhaus rau kev tshawb fawb thiab kev tsim tawm, peb feem ntau tau txais cov khoom lag luam tseem ceeb ntawm nws cov haujlwm, kev tshwm sim, thiab kev tshawb xyuas cov ntawv thov.

Metalothioneeins muaj me me, cysteine-nplua nuj protein pom nyob thoob plaws . lawv cov txiaj ntsig tseem ceeb suav nrog:

• ION ION ionostasis: Kev tswj hwm cov tseem ceeb ntawm zinc (zn²⁺) thiab tooj (cu⁺) tsis pub dhau hlwb
• Hnyav hlau detoxification: Khi rau cov tsis yog cov hlau tseem ceeb xws li cadmium (CD²⁺) thiab mercury (hg²⁺) ²
• Oxidative Kev Nyuaj Siab Teb Teb: Scavenging dawb radicals los ntawm cov pab pawg thiol hauv csteine residues³
• HLAU HLOOV: Ua kom haum zinc faib rau Metallroenzymes thiab cov khoom sib txuas

Ntau yam prប្រាាors prcregatate mt qhia:

• Kev Raug Hlau Hlau: Zinc, tooj liab, cadmium (pom hauv kev tshawb fawb ntawm tes) ⁵
• Oxidative Cov Kev Tiv Thaiv: Cov pa oxygen) (Ros), o o o o
• Cov cim qhia hormon: Glucocorticoids hauv Kev Nyuaj Siab Cov Lus Teb Txoj Kev
• Kev noj haus khoom noj muaj haus: Zinc-nplua nuj cov zaub mov (hauv Vivo Soj ntsuam) ⁸

Yog . Neeg tib neeg nthuav qhia plaub tus thawj mt isoforms:

• Mt -1 / mt -2: Ubiquitous (nplooj siab, raum, plab hnyuv) ⁹
• Mt -3: Lub hlwb tshwj xeeb kev ua haujlwm ntawm kev loj hlob regulator¹⁰
• Mt -4: Cov ntaub so epithelial epithelial

Cov protein no tau encoded los ntawm cov caj ces ntawm chromosome 16 thiab koom rau hauv cov txheej txheem Physiological {}} ¹²

Kwv yees li 30% ntawm mt cov amino acids yogcysteine- Lub leej faj-muaj cov seem uas tsim cov hlau-ua rau cov pawg hlau {}} }³ tus qauv no pab:

• High Hlau-Kev Siv Peev Xwm (7-12} ions ib molecule)
• Redox Kev Ua Rau Electron Hloov
• Asformational yooj yim

Peb liMetallothionein HmoovUa haujlwm raws li:

Tus Qauv SivRau Kev Tshawb Fawb Hlau

ReagentHauv Antioxidant Muaj Peev Xwm

Molecular ToolRau cov protein-hlau kev txhawb zog

Cov Khoom Siv Tswjhwm Zoorau kev kuaj mob

Metalothionein yog ib qho kev tswj hwm cov khoom siv hlau nyob rau hauv tib neeg lub hom phiaj kev pab cuam, kev siv hluav taws xob tsis zoo rau kev kawm txog cov kab mob biological, tshwj xeeb hauv biochemistry thiab molecular {{5 5 5}}

Ntawv Sawv cev
¹ Maret, w . (2021) .Metalothioneins. hauvPhau Ntawv Qhia Txog Biologisation III(pp {. 529-535) {. elsevier {}}
² ruttkay-nedecky, b .}}}. (2013 {{4}Int J Mol Sci, 14 (3), {6044-6066. doi: 10.3390 / iJMS14036044
◆ vašák, m . (2005) .J biol inorgen, 10 (1), {1-10. doi: 10.1007 / s 00775-005-0631-}}}}}}}}}}}}}}}
⁴ mais, {{. t}}}}}} (2000).Cell Mol Biool, 46(2), 347-365.
⁵ Klaassen, c . d . (2019).Toxicol Sci, 167 (1), {1-3. doi: 10.1093 / toxsci / kfy244
⁶ Sato, m . (1991) .Cov Kws Ntxub Pab, 57, 507-520.
⁷rew, g {{. k {. (2000) {3} {3}Biochem pharmolol, 59 (1), {95-104. Doi: 10.1016 / s {} {00310-9
Ž, j {{. c . (2011) {{3} {3}Adv zaub mov, 2 (2), {101-111. doi: 10.3945 / .110.000232
⁹ palmiter, r . d . (1998) {3} {3}PRO NETL KEV KAWM SCI Tebchaws Asmeskas, 95(15), 8428-8430.
¹⁰ uchida, y {. (1994) .Neuron, 13 (1), {{11-16. doi: 10.1016 / {}} (990455-3
¹¹ QUBE PE, c {. j . (1994) {3} {3}Biochemistry, 33 (23), 7250-7259. doi: 10.102 / bi00189a029
¹² West, {{. k {{{}}} {2} {{4 4}}Comp Biochem Physiol C Toxicol Tshuaj, 148 (1), {1-6. doi: 10 . 1016 / j.cbpc {{5 5}
¹³devila, m . (2012).Mellomics, 4 (1), {19-32. doi: 10.1039 / c1mt00123K