Taw qhia ntawm Vinblastine
Vinblastine hmoovyog cov khoom muaj purity siab. Catharanthusroseus (Linn.)G. daon yog tag nrho cov nyom extract ntawm Catharanthusroseus (Linn.) G.daon, Apocynaceae. Changchun, tseem hu ua Yanlahong, txhua hnub tshiab, plaub lub caij nplooj ntoos hlav, peb caug txhiab paj, thiab lwm yam, feem ntau tsim nyob rau hauv Hainan, Yunnan, Guangdong, Guangxi thiab lwm qhov chaw. Changchun Chemicalbook paj saj iab me ntsis, txias, rov qab mus rau lub siab meridian, nrog detoxification, Qingreping daim siab thiab lwm yam teebmeem. nplua nuj nyob rau hauv terpenoid alkaloids, dipolyindole alkaloids, monoindole alkaloids thiab flavonoids, cov extract ntawm roseus catharsis muaj kev kho mob rau ntau yam qog nqaij hlav, kub siab, carbonic cancer, scalding, malaria, raws plab thiab Hodgkin tus kab mob, thiab muaj pharmacological kev ua ub no xws li hypoglycemia.
Subshrubs, me ntsis branched, mus txog 60cm, SAP thaum so, glabrous los yog tsuas glabrous thoob plaws; Stems subsquare, striate, grey-ntsuab; Lub internode ntev yog 1 ~ 3.5cm. Nplooj ntawm Chemicalbook membranous, obovate oblong, 3 ~ 4cm ntev, 1.5 ~ 2.5cm wide, apex rounded, luv taw tes, puag broadly cuneate rau cuneate, nqaim mus rau hauv petiole; Lateral leeg muaj txog 8 khub
Mechanism ntawm kev txiav txim ntawm vinblastine
1.. Antihypertensive nyhuv: Intravenous txhaj ntawm Vinca tag nrho alkali muaj antihypertensive nyhuv rau anesthetised miv thiab luav, thiab cov ntshav siab poob sai heev, uas yog txawv los ntawm qeeb antihypertensive nyhuv ntawm Roflum tag nrho alkali npaj, thiab cov nyhuv antihypertensive yog nrog los ntawm cov ua pa tob tob thiab qhov amplitude nce. Txiav cov hlab ntsha vagus lossis siv atropine tsis cuam tshuam rau nws cov nyhuv antihypertensive. Tag nrho cov alkali kuj muaj cov nyhuv ntawm dilating coronary hlab ntsha (nyob rau spasmolytic ganglion blocker).
2. Cov nyhuv hypoglycemic hauv kev kho mob ntshav qab zib mellitus nrog Changchun Mosaic thiab tag nrho cov nroj tsuag. Vinblastine, epoxy-vinblastine, Roxyline thiab tetrahydrochicken pob txha Changshan tau raug cais tawm ntawm Catharanthus roseus nrog ntau qib ntawm cov teebmeem hypoglycemic, pib qeeb tab sis kav ntev. Cov dej extract ntawm nplooj tuaj yeem txo cov ntshav qab zib hauv cov luav thiab cov dev uas muaj ntshav qab zib los ntawm alloxacil.
3. Vinblastine hmoovmuaj Diuretic nyhuv Cov extract Vindolinine muaj diuretic nyhuv rau nas nyob rau hauv saline load.
4. Lwm yam teebmeem Tag Nrho Vinca alkali tsis muaj excitatory nyhuv ntawm lub tsev menyuam thiab cov hnyuv hauv vitro, tab sis cov koob tshuaj loj muaj inhibitory cuam tshuam rau lub plawv hauv vitro. Nws tuaj yeem siv los ua tus neeg sawv cev hemostatic thaum lub uterine los ntshav tau qhia txawv teb chaws, thiab nws cov cag tuaj yeem siv rau kev rho menyuam. Tag nrho cov alkaloid qhov chaw muaj qhov sib txawv ntawm cov tshuaj tua kab mob.
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Primroses alkaloid derivatives yog cov khoom ntawm kev hloov kho cov qauv ntawm vinca alkaloid los ntawm ob yam. Ua ntej, raws li tus qauv-kev sib raug zoo ntawm vinca alkaloid, lub active centre ntawm vinca alkaloid tau hloov mus ua ib tug series ntawm vinca alkaloid derivatives, thiaj li nrhiav tau vinca alkaloid nrog muaj zog pharmacological kev ua ub no, qis toxicity thiab wider anti-tumor spectrum. . Thib ob, nyob rau hauv lub ntsiab lus ntawm kev ua kom muaj kev ua haujlwm pharmacological, cov phiaj xwm pab pawg (tshwj xeeb oligopeptides, monoclonal antibodies thiab folic acid, thiab lwm yam) tau nkag mus rau hauv qee qhov chaw tsis muaj zog los ua ke ntawm cov phiaj xwm precursors ntawm vinca alkaloid derivatives, txhawm rau txo qhov tsis zoo tshwm sim. ntawm vinca alkaloid tshuaj thiab txhim kho nws cov kev kho mob index. Changchun Fluning yog ib tug difluorine-hloov alkaloid derivative ntawm Changchun los ntawm activating C-20 'site ntawm vinblastine puag nyob rau hauv super-acid ib puag ncig nrog Vinblastrebine raws li cov khoom pib. Cov kev tshawb fawb tau pom tias qhov kev sib raug zoo ntawm Vinflunin rau tubulin khi qhov chaw yog me dua li ntawm lwm cov vinca alkaloids, thiab lub helix induced los ntawm Vinflunin yog me dua thiab lub sij hawm so ntawm helix luv dua, yog li nws tuaj yeem tshem tawm ntawm cov hlwb hauv lub sijhawm luv. , uas ua rau cov neurotoxicity ntawm Vinfunin tsis muaj zog. Ntxiv mus, qhov inhibitory tus nqi ntawm vinfunine ntawm cov qog loj hlob hauv vivo yog siab dua vinvinorobin.
Kev siv vinblastine
1.22 tus neeg mob Hodgkin tus kab mob, 11 tus neeg mob lymphatic sarcoma, 1 kis ntawm malignant reticulum cell hyperplasia, mycosis fungoides, leukemia, hlav ntsuab, qog nqaij hlav mediastinal thiab 6 tus neeg mob ntawm reticulum cell sarcoma tau kho nrog vincristine sulfate. Cov txiaj ntsig tau ploj tag nrho hauv 4 qhov xwm txheej, siv tau 15 kis, siv tau 12 kis, siv tsis tau 6 tus neeg mob, ua rau muaj 3 mob, tsis paub txog 3 kis, tag nrho cov txiaj ntsig zoo ntawm 72.1 feem pua.
2. Vinblastine sulfate 10mg (ib zaug koob), ob zaug ib lub lim tiam, intravenously, tag nrho 50mg. 5 tus neeg mob qog ntshav qog ntshav ntshav, 1 kis ntawm cov qog ntshav qog ntshav qog ntshav qab zib thiab 2 kis mob qog noj ntshav thiab mob ntev myelogenous leukemia tau kho. Cov txiaj ntsig: 2 kis tau ploj tag nrho thiab 3 kis tau pom pom muaj txiaj ntsig zoo.
3. Cov neeg mob ntshav siab Catharina Siegesbeckiae 12g, Herba Siegesbeckiae 9g, cassia thiab chrysanthemum 6g txhua. Decoction nrog dej muaj txiaj ntsig zoo rau kev txo cov ntshav siab.Yuav tiv tauj peb li cas?
Peb yog ib lub tuam txhab nrog ntau xyoo ntawm kev muag khoom nyob rau hauv cov nroj tsuag extract kev lag luam. Tom qab xyoo ntawm kev ua haujlwm, peb muaj ntau yam khoom, xws li txiv hmab txiv ntoo thiab zaub hmoov, tshuaj pleev ib ce, ntsiav tshuaj khoom qab zib thiab lwm yam khoom. Peb yog cov kws tshaj lij cov khoom siv raw khoom. Tam sim no, peb lub tuam txhab muag pheej yigVinblastine hmoovnyob rau hauv tej, uas yog dav siv nyob rau hauv cov khoom kho mob, tshuaj, tshuaj pleev ib ce thiab lwm yam teb. Cov uas yuav tsum tau ua cov khoom kho mob tuaj yeem yuav cov khoom siv raw no. Lub caij no, raws li peb cov khoom raug muag ncaj qha los ntawm cov chaw tsim khoom, qhov zoo ntawm peb cov khoom yog guaranteed thiab peb tuaj yeem so assured mus yuav lawv.
Yog tias koj xav yuav lossis txaus siab rau nws, koj tuaj yeem xa email rau peb qhov chaw ua haujlwm emailella.zhang@huilinbio-tech.com iblos ntawm lub vev xaib thoob ntiaj teb. Peb yuav teb koj sai li sai tau thaum koj pom cov lus. Tsis tas li ntawd, koj tuaj yeem mus saib qhov chaw offline. Peb lub tuam txhab nyob hauv Chav 706, Tsev B, Fengze Science Park, No. 170, West Street, Yanta District, Xi 'an City, Shaanxi Province. Zoo siab txais tos koj tuaj xyuas.