Product Summary
CJC-1295(CAS 863288-34-0) yog ib qho kev tsim kho kev loj hlob hormone-releasing hormone (GHRH) analog, tsim tshwj xeeb los kov yeej cov kev txwv ntawm haiv neeg GHRH, uas muaj cov ntshav plasma luv heev ib nrab-lub neej vim yog cov enzymatic degradation sai. [3]. Nws cov qauv molecular suav nrog kev hloov kho cov tswv yim uas txhim kho nws txoj kev ruaj ntseg thiab ua kom ntev nws cov dej num hauv cov kev tshawb fawb preclinical. [1]. Ib qho tseem ceeb ntawm nws tus qauv tsim yog qhov sib ntxiv ntawm Drug Affinity Complex (DAC), uas tso cai rau cov peptide los khi rov qab mus rau albumin hauv cov hlab ntsha, ua rau nws txuas ntxiv ib nrab ntawm - lub neej thiab ua kom muaj kev tso tawm mus tas li.[2].
Qhov kev ua yeeb yam ntev ntev no ua rau CJC-1295 yog ib qho kev tshawb fawb tsis muaj nuj nqis rau kev tshawb xyuas qhov cuam tshuam ntawm kev txhawb nqa GHRH rau ntawm hypothalamic- pituitary axis. Los ntawm kev txhawb nqa lub cev ntau dua, pulsatile tso tawm ntawm endogenous txoj kev loj hlob hormone (GH) nyob rau lub sijhawm ntev, nws yooj yim rau kev kawm ntawm GH thiab insulin zoo li kev loj hlob zoo li 1 (IGF-1) lub cev tsis tas yuav tsum tau noj ntau zaus. [2]. Nws cov ntawv thov kev tshawb fawb feem ntau tsom rau kev nkag siab txog kev tswj hwm metabolic, lub cev muaj pes tsawg leeg hloov kho, thiab cov txheej txheem ntawm kev loj hlob anabolic.
Tsis tas li ntawd, nws txhim kho kev ruaj ntseg tiv thaiv enzymatic degradation, ua tiav los ntawm kev hloov cov amino acid (xws li kev hloov ntawm alanine nrog D-alanine ntawm txoj hauj lwm 2), tso cai rau cov kws tshawb fawb los tswj GH qib siab rau ob peb hnub, muab cov qauv zoo sib xws rau kev kawm txog cov teebmeem hauv qab ntawm GH secretion ntawm ntau cov ntaub so ntswg thiab cov txheej txheem metabolic.[3]. Raws li xws li, CJC-1295 tseem yog qhov tseem ceeb hauv kev tshawb fawb endocrinology thiab cov metabolism hauv kev tshawb nrhiav cov tswv yim kho mob uas cuam tshuam txog kev loj hlob hormone tsis txaus thiab cov kab mob metabolic.
Physicochemical Profile
| Khoom | Specification |
|---|---|
| Kev tsim khoom | CJC-1295 |
| Cov yam ntxwv ntawm lub cev | Dawb lyophilized hmoov |
| Molecular Formula | C₁₅₂H₂₅₂N₄₄O₄₂ |
| Molecular Mass | 3367.0 g / mol |
| CAS Registry Number | 863288-34-0 |
| Kev soj ntsuam Purity | >98.0% (HPLC methodology) |
| Lub Sijhawm Stability | 36 lub hlis (txheej txheem cia) |
| Solvation Properties | Soluble hauv dej bacteriostatic |
| Kev Cia Siab | -20 degree, tiv thaiv los ntawm lub teeb thiab av noo |
Cov cwj pwm tseem ceeb
- Exceptional Purity: Kev soj ntsuam nruj zoo siv rov qab- theem siab -kev ua haujlwm ua kua chromatography (HPLC) thiab kua chromatography-mass spectrometry (LC-}MS) lees paub purity theem siab tshaj 98.0%, ua kom ntseeg tau cov txiaj ntsig kev tshawb fawb thiab kev sim rov ua dua tshiab[1].
- Optimized ruaj khov: Cov txheej txheem lyophilized qhia txog kev txhim kho kev ruaj ntseg profiles, tswj cov qauv kev ncaj ncees thiab kev ua haujlwm lom neeg thaum khaws cia ntawm qhov ntsuas kub (-20 degree), yog li khaws cia kev tshawb fawb ua haujlwm thoob plaws lub sijhawm kawm txuas ntxiv[2].
- Synthetic Production: Ua los ntawm cov khoom siv siab heev-theem peptide synthesis thev naus laus zis, cov txheej txheem no tau lees paub tshwj xeeb batch- rau-batch sib xws thaum muaj txiaj ntsig zoo tshem tawm cov kev pheej hmoo cuam tshuam nrog cov kab mob lom xws li endotoxins thiab microbial agents [3].
- Daim ntawv thov tshawb fawb: Tshwj xeeb engineered rau kev soj ntsuam kuaj, qhov compound no yog tsim rau ntau yam kev tshawb fawb qauv xws li nyob rau hauv vitro cellular assays thiab physiological mechanism kev tshawb fawb, muab kev ua tau zoo nyob rau hauv cov kev sim siab. [1].
Kev tshuaj xyuas
Kev tshawb fawb cuam tshuam
Nco tseg: Cov kev soj ntsuam hauv qab no yog muab los ntawm kev tshawb fawb preclinical luam tawm. Cov khoom no tsuas yog siv rau kev tshawb fawb thiab tsis yog rau tib neeg noj.
Kev tshawb fawb tshawb fawb siv CJC-1295 tau pab txhawb ntau yam kev tshawb fawb los ntawm nws cov khoom siv tshuaj tshwj xeeb.[2,3,4]:
- Endocrine Modulation Studies: Pab kom cov ncauj lus kom ntxaws txog kev loj hlob hormone pulsatile secretion qauv thiab lawv cov txheej txheem tswj kev nyuaj, muab kev nkag siab rau hypothalamic-pituitary axis functionality[3].
- Kev Tshawb Nrhiav Metabolic Pathway: Ua kom yooj yim rau kev tshawb nrhiav cov khoom noj khoom haus faib cov txheej txheem thiab kev tswj hwm cov txheej txheem metabolic, tshwj xeeb tshaj yog hais txog lipid metabolism thiab protein synthesis txoj hauv kev sim ua qauv [4].
- Receptor Dynamics Analysis: Txhawb kev tshawb fawb txog kev loj hlob hormone- tso tawm cov tshuaj hormone (GHRH) receptor kev sib cuam tshuam thiab tom qab intracellular signaling cascade activation, pab txhawb kev nkag siab ntawm receptor-ligand kinetics [2].
- Kev Tshawb Fawb Txog Kev Ruaj Ntseg: Muab kev nkag siab zoo rau cov tswv yim hloov kho peptide thiab cov qauv kev txhim kho kom zoo rau kev txhim kho kev tshawb fawb siv tau thiab lub sijhawm tshawb nrhiav ntev[3].
Cov ntawv thov tshawb fawb
CJC-1295 ua haujlwm rau ntau lub hom phiaj tshawb nrhiav thoob plaws ntau yam kev kawm txuj ci, ua kom pom kev siv hluav taws xob tshwj xeeb hauv thaj chaw hauv qab no[1,3,5]:
- Kev tshawb nrhiav endocrinology: Ua hauj lwm hauv cov kev tshawb fawb sophisticated soj ntsuam kev loj hlob hormone pulsatility yam ntxwv thiab complex endocrine tswv yim mechanisms, pab kom nkag siab txog cov kev cai hormonal systems.[3].
- Kev tshawb nrhiav Metabolic: Siv rau hauv kev tshawb nrhiav kev sib raug zoo ntawm kev loj hlob hormone kev ua si thiab cov txheej txheem metabolic, tshwj xeeb tshaj yog nyob rau hauv cov kev tshawb fawb soj ntsuam lub zog homeostasis thiab substrate siv.[5].
- Pharmaceutical Development: Ua hauj lwm raws li cov ntaub ntawv tseem ceeb rau kev txhim kho kev ruaj ntseg - tso tawm peptide formulations thiab optimizing xa tshuab rau kev tshawb fawb tebchaw[1].
- Physiological Studies: Siv rau hauv kev tshawb fawb qib siab tshawb xyuas cov qauv kev tso tawm cov tshuaj hormones thiab lawv cov teebmeem physiological ntawm ntau lub cev thiab kev ua haujlwm metabolic[3].
- Kev tshawb fawb biochemical: Ua hauj lwm hauv cov kev tshawb fawb ntxaws tshawb xyuas peptide stability tsis thiab receptor binding kinetics, pab kom nkag siab txog kev sib cuam tshuam ntawm molecular mechanisms [5].
CJC-1295 vs. Tesamorelin: Ib qho piv txwv
Zoo sib xws
- Lub Hom Phiaj thiab Mechanism:Ob leeg yog cov tshuaj sib xyaw ua ke ntawm Kev Loj Hlob Hormone-Tshuaj Hormone (GHRH). Lawv feem ntau ua haujlwm los ntawm kev khi rau GHRH receptors ntawm lub caj pas pituitary, stimulating synthesis thiab tso tawm ntawm endogenous loj hlob hormone (GH).
- Endogenous GH Secretion:Tsis zoo li kev tswj hwm kev loj hlob hormone ncaj qha, ob qho tib si peptides txhawb lub cev tus kheej pulsatile secretion ntawm GH, uas yog suav hais tias yog ib qho qauv ntawm lub cev thiab lub cev.
- Kev Tshawb Fawb Tseem Ceeb:Lawv cov ntawv thov kev tshawb fawb tseem ceeb tau sib raug zoo, tsom mus rau cov kev tshawb fawb metabolic, kev tswj hwm lub cev (tshwj xeeb yog txo cov visceral adipose cov ntaub so ntswg), thiab nkag siab GH-txoj kev cuam tshuam.
- Txhim kho Stability:Ob qho peptides tau tsim kho kom ruaj khov thiab muaj lub sijhawm ua haujlwm ntev dua li haiv neeg GHRH, uas yog degraded sai heev los ntawm enzymes hauv lub cev.
Qhov txawv
| Feature | CJC-1295 | Tesamorelin |
|---|---|---|
| Cov Qauv Tseem Ceeb | Ib qho hloov kho ntawm GHRH (1-29) fragment. | Muaj tag nrho 44 amino acid ib ntus ntawm GHRH nrog rau kev hloov kho trans-3-hexenoic acid. |
| Kev hloov pauv tseem ceeb | Drug Affinity Complex (DAC):Tso cai rau nws khi reversibly rau albumin hauv cov hlab ntsha. | Amino Acid Hloov:Nta ib qho kev hloov kho tshwj xeeb los txhim kho kev ruaj ntseg thiab receptor khi. |
| Ib nrab-Lub Neej & Kev Ua Haujlwm | Sustained - Tso tawm:Qhov kev hloov kho DAC muab nws ib nrab ntev heev -lub neej (ob peb hnub), ua rau lub sijhawm ntev thiab kev tso tawm ntawm GH. | Luv -Acting:Muaj luv luv ib nrab -lub neej (feeb mus rau ob peb teev). Yuav tsum tau siv ntau zaus kom tswj tau cov nyhuv. |
| Tso Profile | Txhawb nqa kev nce siab ntawm GH qib, uas ua rau muaj kev sib txuas ntev ntev ntawm IGF-1. | Tsim los ua kom zoo li lub ntujpulsatileKev tso tawm ntawm GH ntau dua, nrog lub siab tshaj plaws tom qab txhua koob. |
| Kev tshawb fawb tseem ceeb | Feem ntau kawm txog nws lub peev xwm muabtxuas ntxiv GH stimulation, muaj txiaj ntsig zoo rau kev tshawb nrhiav ntev -cov teebmeem anabolic thiab metabolic. | Kev tshawb fawb hnyav hauv cov ntsiab lus kho mob tshwj xeeb, tshwj xeeb tshaj yog raukho HIV-sociated lipodystrophythiab nws cov kev xaiv txo cov roj visceral. |
| Kev tswj hwm xwm txheej | Feem ntau yog kev tshawb fawb tshuaj, tsis pom zoo rau kev siv kho mob hauv khw loj. | FDA- Pom zoo:Pom zoo raws li lub npe Egrifta® rau kev kho mob plab rog ntau dhau hauv cov neeg mob HIV nrog lipodystrophy. |
Nquag Nug Yam
Q: Dab tsi yog qhov kev tshawb fawb tseem ceeb ntawm CJC-1295 piv rau lwm cov GHRH analogs?
A: CJC-1295 nta ib qho kev hloov pauv molecular tshwj xeeb uas ua rau siv tshuaj affinity complex (DAC) thev naus laus zis, muab kev ncua ntev ib nrab ntawm lub neej thiab kev ua haujlwm txhawb nqa hauv kev tshawb fawb. Qhov no tso cai rau tsawg dua koob tshuaj hauv cov kev tshawb fawb ntev tshawb nrhiav kev loj hlob hormone pulsatility.
Q: Yuav ua li cas yog qhov purity ntawm koj CJC-1295 pov thawj?
A: Each batch undergoes comprehensive analytical testing using high-performance liquid chromatography (HPLC) and mass spectrometry, with certificates of analysis available upon request confirming >98.0% ntshiab.
Q: Dab tsi yog qhov kev pom zoo rov tsim kho cov txheej txheem rau kev tshawb fawb?
A: Rau cov ntaub ntawv tshawb fawb, rov ua dua nrog cov dej bacteriostatic rau qhov xav tau. Cov kev tshawb fawb ib txwm muaj nyob ntawm 1-5 mg/mL. Ib txwm siv cov txheej txheem tsis muaj menyuam thiab khaws cov peptide rov ua dua ntawm 2-8℃rau kev siv sijhawm luv.
Q: Koj puas muab cov ntaub ntawv txhawb nqa rau kev tshawb fawb ua raws?
A: Yog lawm, peb muab cov ntaub ntawv ua tiav nrog rau daim ntawv pov thawj ntawm kev tshuaj xyuas, cov ntaub ntawv kev nyab xeeb ntawm cov ntaub ntawv, thiab cov ntaub ntawv tshawb fawb siv los xyuas kom ua raws li cov cai hauv tsev.
Q: Puas muaj ib qho kev txiav txim siab tshwj xeeb rau kev ruaj ntseg ntev -?
A: Rau kev khaws cia kom zoo, khaws cov vials uas tsis tau qhib ntawm -20℃hauv desicated. Tsis txhob rov ua kom khov-thaw mus ntxiv vim qhov no yuav cuam tshuam rau peptide kev ncaj ncees.
Q: Cov qauv kev tshawb fawb dab tsi tau siv CJC-1295?
A: Qhov sib xyaw no tau ua haujlwm hauv ntau yam kev tshawb fawb qauv suav nrog hauv vitro cellular assays, kev tshawb fawb tsiaj metabolic, thiab kev tshawb nrhiav endocrine system, feem ntau tsom rau kev loj hlob hormone mechanisms.
Q: Cov kev xaiv them nyiaj twg muaj rau cov tsev kawm tshawb fawb?
A: Peb lees txais ntau txoj hauv kev them nyiaj nrog rau kev xa xov xaim, credit cards, thiab kev txiav txim hauv tsev.
Daim ntawv pov thawj
Yuav tiv tauj peb li cas?
Peb lub tuam txhab yog ib tug kws tshaj lij ntawm ib nrab- cov ntaub ntawv tiav, suav nrog cov nroj tsuag rho tawm, txiv hmab txiv ntoo thiab zaub hmoov, tshuaj pleev ib ce, ntsiav tshuaj khoom qab zib, thiab lwm yam khoom. Peb cov khoom raug xa ncaj qha los ntawm cov chaw tsim khoom, yog li tus nqi yog qhov zoo heev, thiab qhov zoo yog lav kom koj tuaj yeem yuav nrog kev ntseeg siab.
Tam sim no peb lub tuam txhab kub-muagCJC-1295, yog tias koj txaus siab rau cov khoom no thiab xav paub txog nws, koj tuaj yeem sab laj nrog peb tus thawj tswj hwm tus account los ntawm thoob ntiaj teb lub vev xaib lossis email. Peb tus email chaw nyob yogella.zhang@huilinbio-tech.com.
Kev Cai Citations
[1] National Center for Biotechnology Information. PubChem Compound Summary for CID 16165308
[2] Teichman, SL, et al. (2006). Endocrine Reviews, 27(4), 431-438
[3] Jetté, L., et al. (2005). Phau ntawv Journal of Endocrinology, 185(3), 479-488
[4] Kev tshawb fawb txog cov teebmeem metabolic ntawm kev loj hlob hormone hloov pauv
[5] Kev tshawb fawb txog kev kho peptide thiab lawv cov ntawv thov kev tshawb fawb
Kev siv Disclaimer
Cov khoom no yog tsim tshwj xeeb rau kev tshawb fawb lub hom phiaj nyob rau hauv kev tswj chaw kuaj ib puag ncig. Nws tsis yog npaj rau kev kuaj mob, kho, lossis siv tib neeg. Cov neeg yuav khoom yuav tsum ua raws li tag nrho cov kev cai siv tswj xyuas cov ntaub ntawv tshawb fawb. Xi'an Huilin Biological Technology Co., Ltd. xav tias tsis muaj kev lav phib xaub rau kev siv tsis raug lossis tsis raug tso cai tuav cov khoom no.
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