Taw qhia
Hemin hmoovyog qhov ruaj khov, chloride-bound crystalline daim ntawv ntawm ferriprotoporphyrin IX. Nws yog ib qho hlau-muaj porphyrin complex uas ua haujlwm tseem ceeb ntawm biochemical reagent thiab tus neeg sawv cev tseem ceeb.
Cov khoom no yog muab los ntawm heme, pawg prosthetic tseem ceeb hauv hemoglobin thiab lwm yam hemoproteins. Thaum heme nws tus kheej tsis ruaj khov, qhov tsim ntawm hemin chloride ntsev stabilizes lub molecule, ua rau nws haum rau ntev - lub sij hawm cia, kev tshawb fawb, thiab tshuaj formulation.
Physical & Chemical Parameters
| Parameter | Specification / Tus nqi | Lus Ceeb Toom / Qhov Tseem Ceeb |
|---|---|---|
| Melting Point | ~ 300 degree | Siab thermal stability. |
| Solubility | Xyaum insoluble hauv dej. Soluble hauv dilute alkali daws (xws li, 1M NaOH) thiab DMSO nrog sonication. Insoluble nyob rau hauv dilute acids. | Nws yog ib qho tseem ceeb rau kev npaj cov kev daws teeb meem rau cov tshuaj lom neeg. |
| Kev ruaj ntseg | Nyob ruaj khov nyob rau hauv kev pom zoo cia.Incompatible nrog muaj zog oxidizing neeg sawv cev.Hluav taws kub. | Yuav tsum ua tib zoo tuav thiab khaws cia. |
| Poob rau ziab | Tsawg dua los yog sib npaug li 2.0% (kev lag luam specification) | Kev tswj xyuas qhov zoo rau cov dej noo. |
Mechanism ntawm Action
Hemin exerts nws thawj cov teebmeem lom los ntawm ib tug dual mechanism, ua haujlwm ob qho tib si raws li ib qho tseem ceeb metabolic precursor thiab raws li ib tug haib modulator ntawm cellular tiv thaiv systems.
- Tawm tswv yim Inhibition ntawm Heme Biosynthesis (Primary Pharmaceutical Action):Hemin txoj kev kho mob feem ntau yog nyob rau hauv kev kho mob ntawm tus mob hepatic porphyrias. Nyob rau hauv cov kev mob no, ib tug genetic defect ua rau cov tshuaj lom tsub zuj zuj ntawm porphyrin precursors. Thaum muab tshuaj intravenously, hemin ua raws li ib tugexogenous qhov chaw ntawm heme, uas muabtsis zoo tawm tswv yim tawm tsamntawm tus nqi -limiting enzyme δ-aminolevulinic acid (ALA) synthase. Qhov no ua rau txo qis kev tsim tawm ntau dhau ntawm neurotoxic porphyrin precursors, yog li daws qhov mob hnyav.
- Induction ntawm Heme Oxygenase-1 (HO-1) thiab Tom ntej Cytoprotection:Hemin yog tus muaj zoginducer ntawm heme oxygenase-1 (HO-1), ib qho kev nyuaj siab tseem ceeb- teb enzyme. HO-1 catalyzes degradation ntawm dawb heme rau hauv biliverdin (ib tug muaj zog antioxidant), carbon monoxide (ib tug taw qhia molecule nrog anti- inflammatory zog), thiab dawb hlau. Qhov systematic induction ntawm txoj hauv kev no los ntawm kev tswj hwm hemin ua rau dav-spectrumcytoprotective, antioxidant, thiab tiv thaiv - cov teebmeem inflammatory.
- Direct Enzyme-zoo li Kev Ua Haujlwm:Vim nws cov hlau -porphyrin core, hemin tuaj yeem ua raws li cov haujlwm ntawm peroxidases thiab catalases. Nws tuaj yeem ua rau cov tshuaj tiv thaiv redox, ua rau nws lub luag haujlwm hauv kev sim biochemistry thiab muaj peev xwm kho tau.
Cov txiaj ntsig tseem ceeb & Kev ua tau zoo
Kev ua ntau yam ntawm hemin txhais ua ntau yam txiaj ntsig:
- Clinically proven rau mob Porphyria:Nws yog tusthawj- kab, txoj sia -txuag kev kho mobrau mob hnyav ntawm lub siab porphyrias, sai sai thim rov qab biochemical txawv txav thiab cov tsos mob neurological.
- Muaj peev xwm HO-1 Inducer nrog Broad Protective Effects:Raws li HO-1 inducer muaj zog, hemin qhib txoj hauv kev tiv thaiv cellular tseem ceeb, muab cov txiaj ntsig zoo hauv kev tshawb fawb qauv ntawmoxidative kev nyuaj siab, ischemia-reperfusion raug mob, thiab o.
- Inhibition ntawm Cancer Cell Proliferation:Cov kev tshawb fawb preclinical qhia tias hemin tuaj yeeminhibit qhov kev loj hlob ntawm ntau yam kab mob qog noj ntshav(xws li, kab mob qog noj ntshav pancreatic) thiab txhim kho cov teebmeem ntawm lwm cov tshuaj tiv thaiv kabmob xws li statins.
- Qhov tseem ceeb ntawm kev loj hlob ntawm cov kab mob microorganisms:Hemin yog ibtseem ceeb loj hlob ntxivrau cultivating fastidious anaerobic kab mob thiab heme- cov kab mob tsis zoo xws liPorphyromonas gingivalis yog cov kab mobthiabBacteroideshom kev tshawb fawb microbiological.
Cov ntawv thov tseem ceeb
| Kev lag luam / teb | Piv txwv daim ntawv thov | Lub luag haujlwm ua haujlwm & Cov txiaj ntsig |
|---|---|---|
| Pharmaceuticals | Txhaj tshuajrau mob porphyria mob thiab lwm yam kab mob siab porphyrias. | Muab cov active heme xav tau rautawm tswv yim inhibition ntawm lom porphyrin synthesis. |
| Kev tshawb fawb biomedical | Inducer ntawm HO-1 los kawm cytoprotection, qauv ntawm o, ischemia, thiab cov kab mob neurodegenerative. | Cov cuab yeej txhim khu kev qha rauqhib txoj kev tiv thaiv endogenous HO-1hauv vitro thiab vivo. |
| Microbiology & Cell Culture | Cov khoom tseem ceeb hauvtxhawb nqa kab lis kev cai xov xwmrau fastidious anaerobes (piv txwv li, hauv Brucella broth, Thioglycolate broth). | Muab cov hlau tseem ceeb thiab porphyrin rau microbial kev loj hlob thiab metabolism. |
| Biochemistry & Biotechnology | Mimic ntawm peroxidase / catalase enzymes rau biocatalysis kev tshawb fawb thiab kev txhim kho biosensor. | Muab qhov ruaj khov thiab tus nqi - zooenzyme cofactor qauvrau cov tshuaj tiv thaiv catalytic. |
| Nutraceuticals & Supplements (Regulated) | Qhov chaw ntawm bioavailable heme hlau (raws li porphyrin hlau) rau cov khoom noj khoom haus. | Cov hlau nqus tau zoo heev rau kev daws qhov tsis txaus. |
FAQ: Cov lus nug nquag nug
Q: Qhov txawv ntawm Hemin, Heme, thiab Hematin yog dab tsi?
A: Heme yog lub ntsiab lus dav dav rau cov hlau -protoporphyrin complex pom hauv hemoglobin. Hemin yog qhov tshwj xeeb, ruaj khov chloride ntsev ntawm oxidized heme (Fe³⁺) siv hauv kev lag luam thiab kev tshawb fawb. Hematin feem ntau yog hais txog hydroxide daim ntawv ntawm heme thiab feem ntau siv sib hloov nrog hemin hauv cov ntaub ntawv kho mob thaum tham txog cov tshuaj txhaj rau porphyria. Hemin (chloride) yog cov khoom pib siv rau cov tshuaj formulations.
Q: Puas yog hemin soluble hauv dej?
A: Tsis yog. Hemin hmoov yog xyaum insoluble hauv dej ntshiab. Rau kev sim siv, nws yog feem ntau yaj nyob rau hauv ib tug qaug zog alkaline tov (xws li, 0.1M NaOH) los yog organic solvents zoo li DMSO nrog kev pab los ntawm sonication.
Q: Yuav ua li cas yog ib qho tshuaj hemin npaj rau kab lis kev cai ntawm tes?
A: Ib txoj hauv kev yog kom yaj cov hmoov hemin hauv ib lub ntim me me ntawm 1M sodium hydroxide, tom qab ntawd tam sim ntawd dilute nws mus rau hauv qhov tsis sib xws (xws li PBS) rau qhov xav tau ua haujlwm siab (piv txwv li, 1-10 mM Tshuag). Rau cov xov xwm microbial, npaj tau- ua kom tsis muaj menyuam muaj peev xwm ntxiv rau tom qab autoclaving.
Q: Txoj kev kho mob ntawm kev tswj hwm yog dab tsi?
A: Rau kev kho mob ntawm tus mob porphyria tawm tsam, hemin yog siv los ntawm kev tso dej qeeb. Nws tsis yog npaj rau qhov ncauj lossis lwm txoj hauv kev hauv cov ntsiab lus no.
Q: Puas yog hemin thiab hematin infusion muaj kev nyab xeeb?
A: Txawm hais tias muaj txiaj ntsig zoo, cov tshuaj txhaj tshuaj tuaj yeem cuam tshuam nrog cov kev mob tshwm sim xws li thrombophlebitis (vein o) thiab, tsis tshua muaj, coagulation defects. Cov nqi qis dua tau pom zoo kom txo qis qhov kev pheej hmoo ntawm kev tsis zoo hauv zos.
Tiv tauj peb
Peb siab -purityHemin hmoov(CAS 16009-13-5) yog tsim los ntawm kev tswj xyuas nruj, kev txhawb nqa los ntawm cov ntawv pov thawj ntawm Kev Ntsuam Xyuas (CoA) thiab Kev Nyab Xeeb Cov Ntaub Ntawv (SDS). Txawm hais tias rau kev txhim kho tshuaj pioneering, kev tshawb fawb biomedical nruj, lossis kev siv tshwj xeeb, peb muab cov khoom siv txhim khu kev qha thiab kev txhawb nqa.
Hu rau peb pab neeg hnub no rau request ibdawb technical dossier thiab qauvrau kev tsim nyog.
Koom tes nrog peb rau kev muab khoom sib xws ntawm qhov tseem ceeb biochemical.
Thov hu rau peb ntawmella.zhang@huilinbio-tech.com.
Cim npe nrov: Hemin (hemin chloride) hmoov, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, ntuj, zoo, Tshuag, kev muag
