Taw qhia
D-Leucineyog qhov tsis yog -proteinogenic D-enantiomer ntawm qhov tseem ceeb ceg ntoo - saw amino acid leucine. Tsis zoo li nws cov L-isomer, uas tau muab tso rau hauv cov proteins thiab ua kom cov txheej txheem metabolic tseem ceeb xws li mTOR, D-leucine tsis siv rau hauv cov tsiaj txhu protein synthesis. Cov cuab yeej tshwj xeeb no qhia txog nws cov haujlwm lom neeg sib txawv. Kev tshawb fawb tsis ntev los no tau txheeb xyuas D-leucine ua ibmuaj zog tiv thaiv - tus neeg sawv cev qaug dab peg, ua kom pom kev ua tau zoo dua li L-leucine hauv cov qauv ua ntej. Nws kuj muaj nyob rau hauv tej yam khoom noj thiab yog tsim los ntawm cov kab mob. Cov khoom no yog muab raws li siab - purity tshuaj rau kev tshawb fawb thiab kev loj hlob lub hom phiaj.
Physical & Chemical Parameters
| Parameter | Specification / Tus nqi | Lus Cim / Txoj Kev |
|---|---|---|
| Specific Optical Rotation [ ]²⁰/D | -14℃txog -15℃(c{2}} hauv 6N HCl) | Tus cim tseem ceeb rau enantiomeric purity. |
| Melting Point | ~ 293℃(decomposes) | |
| Solubility hauv dej | 10 mg / ml (~ 76 mM) | Soluble nrog sonication (<60°C). |
| Solubility hauv DMSO | <1 mg/mL (Practically insoluble) | |
| pH (hauv kev daws) | 5.5 - 6.5 | |
| Poob rau ziab | Tsawg dua los yog sib npaug li 0.5% |
Mechanism ntawm Action
D-Leucine's mechanism ntawm kev ua yog txawv ntawm cov tshuaj tiv thaiv kab mob thiab nws cov L- daim ntawv sib piv, sawv cev rau txoj hauv kev tshiab hauv kev tswj qaug dab peg.
- Qhov txawv ntawm L-Leucine:L-Leucine yog ib tug muaj zog activator ntawm mTORC1 signaling txoj kev thiab yog ketogenic. Piv txwv li,D-leucine tsis txhawb kev ua haujlwm mTOR. Qhov no yog qhov tseem ceeb heev vim tias mTOR hyperactivity txuas nrog qee qhov kev mob vwm, qhia tias D-leucine tuaj yeem muab cov ntaub ntawv muaj kev nyab xeeb yam tsis muaj kev txhawb nqa qhov teeb meem cuam tshuam.
- Novel & Rapid Seizure Suppression:Cov kev tshawb fawb ua ntej qhia tau tias D-leucine tuaj yeempotently txiav tsis tu ncua qaug dab peg txawm tias tom qab lawv pib, ib qho txiaj ntsig tsis ib txwm pom nrog L-leucine. Zoo kawg li, nws tau pom tias muaj txiaj ntsig tsawg kawg yog piv rau diazepam hauv kev tawm tsam qaug dab peg.
- Modulation ntawm Synaptic Plasticity: Hauv vitroCov kev tshawb fawb electrophysiology qhia tias D-leucine (tab sis tsis yog L-leucine)txo -lub sij hawm potentiation (LTP)-kev sib cuam tshuam ntawm tes ntawm kev kawm thiab kev nco uas tuaj yeem ua rau tsis zoo nyob rau hauv kev qaug dab peg- yam tsis muaj kev cuam tshuam rau kev sib kis ntawm basal synaptic. Qhov no qhia nws lub hom phiaj tshwj xeeb hyperexcitable neural circuits.
- Tsis paub siab -Affinity Target:Kev tshuaj ntsuam qhia tias D-leucine tsis sib tw rau kev khi ntawm cov chaw paub neuronal receptor rau cov qauv ligands, taw rau ib qhotshiab, unidentified molecular phiajnyob rau hauv lub mammalian paj hlwb.
- Biofilm cuam tshuam:Hauv kev tshawb fawb microbiological, D-amino acids zoo li D-leucine tau pom tiasua rau lub disassembly ntawm cov kab mob biofilms, muab ib lub cuab yeej los kawm txog cov zej zog microbial thiab persistence.
Cov txiaj ntsig tseem ceeb & qhov zoo
- Promising Novel Anti-Ntseeg Profile:Muab cov lus qhia tshiab rau kev tshawb fawb txog kev kho mob - tiv taus qaug dab peg, nrog rau qaug zog qaug dab peg - muaj peev xwm txiav tawm.
- Unique Mechanism:Ua ntawm nws tus kheej ntawm mTOR ua kom thiab classical neurotransmitter receptors, muaj peev xwm zam kev phiv cuam tshuam nrog rau txoj hauv kev no.
- Cov cuab yeej tshawb fawb rau Neuroscience:Ib qho tseem ceeb hauv kev tshawb nrhiav lub luag haujlwm ntawm D-amino acids hauv eukaryotic neurobiology thiab synaptic plasticity.
- Cov cuab yeej rau Microbiology:Pab tau rau kev kawm cov kab mob sib txuas lus, tsim biofilm, thiab dispersal mechanisms.
- High Purity & Specification:Guaranteed tshuaj thiab enantiomeric purity, txhawb los ntawm cov ncauj lus kom ntxaws analytical cov ntaub ntawv nrog rau cov kev hloov kho qhov muag.
Cov ntawv thov tseem ceeb
- Neuroscience & Epilepsy Kev Tshawb Fawb:Lead compound rau kev kawm tshiab los tiv thaiv -kev qaug dab peg mechanisms thiab tsim cov tswv yim kho tshiab rau refractory epilepsy.
- Biochemical & Pharmacological Studies:Siv raws li kev tswj hwm enantiomeric hauv kev sim nrog L-leucine, thiab txhawm rau soj ntsuam cov teebmeem lom ntawm D-amino acid daim ntawv.
- Microbiology & Biofilm Kev Tshawb Fawb:Siv nyob rau hauv kev tshawb fawb los inhibit los yog cuam tshuam cov kab mob biofilms ntawm pathogens nyiamEnterococcus faecalis.
- Analytical Standard:Ua haujlwm raws li tus qauv siv hauv chromatographic (HPLC, CE) thiab spectroscopic tsom xam rau amino acid kom muaj nuj nqis thiab kev txheeb xyuas.
FAQ: Cov lus nug nquag nug
Q: Dab tsi yog qhov txawv ntawm D-Leucine thiab L-Leucine?
A: Lawv yog daim iav- duab molecules (enantiomers). L-Leucine yog ib qho protein- lub tsev thaiv uas ua rau txoj hauv kev anabolic (mTOR). D-Leucine tsis yog siv rau hauv kev sib txuas ntawm cov tsiaj protein thiab tau pom tias muaj cov haujlwm lom neeg sib txawv, tshwj xeeb tshaj yog muaj zog tiv thaiv - qaug dab peg los ntawm kev sib txawv, cov txheej txheem tshiab.
Q: Puas yog D-Leucine yog ib qho kev noj haus ntxiv rau kev qaug dab peg?
A: Tsis yog. Cov ntaub ntawv tiv thaiv - qaug dab peg yog los ntawm kev tshawb fawb tsiaj ua ntej. Cov khoom no yog muag nruj me ntsis rau kev tshawb fawb lub hom phiaj. Nws txoj kev nyab xeeb thiab kev ua tau zoo hauv tib neeg tsis tau tsim. Nws tsis yog npaj rau kev kuaj mob, kho, lossis siv tus kheej.
Q: D-Leucine nyob qhov twg?
A: D-Leucine muaj nyob rau hauv qee cov khoom noj vim yog cov kab mob ua haujlwm thiab tseem tsim los ntawm ntau yam kab mob.
Q: Kuv yuav npaj cov kev daws teeb meem ntawm D-Leucine rau kev sim kab lis kev cai ntawm tes li cas?
A: D-Leucine yog soluble hauv dej (~10 mg/mL). Rau kev soj ntsuam hauv vitro, nws tuaj yeem yaj ncaj qha rau hauv aqueous buffers lossis kab lis kev cai nruab nrab nrog luv sonication. Rau hauv vivo cov kev tshawb fawb, nws tuaj yeem npaj rau hauv cov kua qaub tsis muaj menyuam.
Tiv tauj peb
Xauv lub peev xwm ntawm qhov tshwj xeeb bioactive compound hauv koj qhov kev tshawb pom tom ntej. Peb lub siab -purity D-Leucine yog tus cwj pwm thiab muab cov ntaub ntawv txheeb xyuas dav dav kom ntseeg tau tias muaj txiaj ntsig zoo thiab rov tsim dua tshiab.
Hu rau peb pab neeg muag khoom hnub no rau:Tau txais kev sib tw nqe lus rauR & D lossis ntau qhov ntau.
Thov hu rau peb ntawmella.zhang@huilinbio-tech.com.
Cim npe nrov: d-leucine hmoov, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, ntuj, zoo, Tshuag, kev muag
