Taw qhia
N-Acetyl-L-carnosine (NAC) Hmoovyog aib txwm tshwm sim, acetylated derivative ntawm dipeptide L-carnosine(muaj cov beta-alanine thiab L-histidine). Nws lub ntsiab feature yog qhov sib ntxiv ntawm ib qhoacetyl pawg, kev hloov kho uas muab nws superiorEnzymatic stabilitypiv rau nws niam txiv compound[1]. Feem ntau lees paub hauv kev tshawb fawb biochemical, NAC ua haujlwm ruaj khov uas maj mam tso L-carnosine, molecule renowned rau nws.antioxidant, hlau -chelating, thiabanti-glycation zog. Qhov no ua rau nws muaj kev txaus siab tseem ceeb rau kev tshawb fawb hauvkev laus, oxidative kev nyuaj siab-txog tej yam kev mob, thiab tej yam nqaij mos noj qab haus huv, tshwj xeeb tshaj yog nyob rau hauv ocular thiab neurological ntsiab lus[1].
Biochemical & Physical Parameters
| Parameter | Nqe lus piav qhia / Specification | Tau qhov twg los / Lus Cim |
|---|---|---|
| CAS Nr. | 56353-15-2 | |
| Qhov ntom | 1.343 g / cm³ | |
| Melting Point | 253 - 260ºC | - |
| Dej Solubility | Soluble heev. | Nws yog siv los ntawm kev siv biochemical. |
| Cia | -20 degree, qhuav, tiv thaiv los ntawm lub teeb. | Pom zoo rau kev ruaj ntseg ntev -. |
| Ntsiab Feature | Resistant rau carnosinase hydrolysis. | Cov pab pawg acetyl tiv thaiv nws los ntawm kev tawg sai. |
Mechanism ntawm Action
Kev ua tau zoo ntawm N-Acetyl-L-carnosine tshwm sim los ntawm nws ob lub luag haujlwm uaruaj khov thaujthiab aprecursor rau lub active L-carnosine, uas exerts ntau yam kev tiv thaiv:
Txhim khu kev ruaj ntseg thiab lub hom phiaj xa khoom[1]:
NAC covacetyl pawg ua raws li cov ntaub thaiv npog, ua rau nws tiv taus kev degradation los ntawm enzyme carnosinase, uas sai sai ua rau L-carnosine hauv ntshav thiab ntau cov ntaub so ntswg.
Qhov kev ruaj ntseg no tso cai rau NAC txuas ntxiv mus ntevhauv qhovthiab ua haujlwm li asij hawm- tso dej cia. Thaum xa mus rau lub hom phiaj cov ntaub so ntswg (xws li, lub qhov muag), nws nkag mus qeeb, txhawb nqa deacetylation kom tso tawm cov nquag L-carnosine. Nws qhov txheeb ze hydrophobicity piv rau L-carnosine kuj tseem tuaj yeem pab txhawb kev nkag mus los ntawm cov kab mob lom neeg xws li lub pob txha.
Multimodal Protective Activity ntawm tso tawm L-Carnosine:
Lub active L-carnosine tso tawm los ntawm NAC exerts ob peb synergistic mechanisms:
Antioxidant & Reactive Hom Scavenger: Ncaj nraim quenches teeb meemReactive oxygen hom (ROS)thiab dawb radicals, tiv thaiv cellular Cheebtsam xws li lipids, proteins, thiab DNA los ntawm oxidative puas[1].
Hlau Ion Chelation: khi rau (chelates) pro- oxidative hlau ions xws li tooj liab thiab hlau, tiv thaiv lawv los ntawm catalyzing kev puas tsuaj dawb radical tshua (xws li, Fenton cov tshuaj tiv thaiv).
Advanced Glycation End- khoom (AGE) Inhibitor: Ua raws li akev sib tw inhibitor ntawm protein glycationthiab tej zaum tseem yuav pab thim rov qab ("de-link") ntxov-theem glycation khoom. Kev sib sau ntawm AGEs cuam tshuam rau cov ntaub so ntswg laus thiab teeb meem hauv cov xwm txheej zoo li ntshav qab zib.
Aldehyde Scavenger: Reacts nrog tshuaj lom aldehydes (piv txwv li, 4-hydroxy-2-nonenal) tsim thaum lub sij hawm lipid peroxidation, neutralizing lawv cov kev puas tsuaj rau cov proteins thiab lwm yam molecules[1].
Cov txiaj ntsig & Kev Tshawb Fawb Kev cuam tshuam
Raws li kev tshawb fawb tshawb fawb, N-Acetyl-L-carnosine yog txuam nrog ntau yam txiaj ntsig bioactive:
1. Ocular Health Support:
Kev tshawb fawb dav dav tsom rau nws daim ntawv thov hauvophthalmic formulations(piv txwv li, tshuaj pleev qhov muag). Cov kev tshawb fawb soj ntsuam pom tias cov tshuaj pleev xim NAC tuaj yeem pab txhim kho qhov pom kev pom thiab pom qhov muag pom kev hauv lub hnub nyoog - cuam tshuam cov kab mob cataracts los ntawm kev tawm tsam oxidative kev nyuaj siab thiab protein glycation hauv lub lens. Nws kuj tau kawm los tswjmob ntshav qab zib ocular teeb meem.
2. Neuroprotective Potential:
Kev tshawb fawb qhia tias carnosine thiab nws cov derivatives, suav nrog NAC, tuaj yeeminhibit microglial oxidative kev nyuaj siab thiab o, thiab tiv thaiv cov hlwb neuronal tiv thaiv excitotoxic thiab oxidative insults, tawm tswv yim lub luag hauj lwm hauv kev tshawb fawb ntawm hlwb.
3. Daim ntawv thov kev tu tawv nqaij:
Kawm rau nwsantioxidant zoghauv dermatology. Los ntawm kev tshem tawm cov dawb radicals thiab tiv thaiv lipid peroxidation, nws tuaj yeem pab txo qis cov txheej txheem kev laus uas raug ntxias los ntawm ib puag ncig kev ntxhov siab xws li UV hluav taws xob.
4. Systemic Antioxidant & Anti-glycation Activity:
Raws li ib tug precursor rau L-carnosine, nws pab rau ib tug system- dav tiv thaiv oxidative kev nyuaj siab thiab tsim AGEs, cov txheej txheem txuas mus rau ntau yam hnub nyoog- cuam tshuam thiab metabolic mob.
N-Acetyl-L-carnosine vs. L-Carnosine
| Feature | N-Acetyl-L-carnosine (NAC) | L-Carnosine |
|---|---|---|
| Chemical Structure | L-Carnosine nrog ib pawg acetyl ntxiv. | Dipeptide (beta-alanine + L-histidine). |
| Qhov tseem ceeb tshaj | Siab tiv taus carnosinase. | Ncaj qha bioactive. |
| Metabolic Txoj hmoo | ruaj khov prodrug: maj mam tso L-carnosine dhau sijhawmhauv qhov. | Hydrolyzed sai sai los ntawm carnosinase hauv cov ntshav thiab ntau cov ntaub so ntswg. |
| Siv Kev Tshawb Fawb Txog Kev Tshawb Fawb | Delivery systemrau kev txhawb nqa L-kev ua haujlwm carnosine, tshwj xeeb tshaj yog nyob rau hauv cov tshuaj pleev (ocular). | Kawm txog kev ncaj ncees, mob biochemical. |
| Antioxidant Capacity (hauv vitro) | Tej zaum yuav qhia txawv profiles. Ib txoj kev tshawb fawb sib piv tau sau tseg tias NAC muaj kev ua haujlwm tsis muaj zog antioxidant hauv kev tshuaj xyuas tshuaj. | Muaj zog ncaj qha antioxidant thiab hlau chelator. |
Cov ntawv thov hauv Kev Tshawb Fawb
N-Acetyl-L-carnosine hmoovyog ib tug ntau yam cuab yeej rauhauv vitrothiab kev tshawb fawb preclinical hauv ntau qhov chaw (Rau Kev Tshawb Fawb Siv Tsuas):
Kev Tshawb Fawb Txog Kev Kho Mob
Tus Qauv Tseem Ceeb: Rau kev kawm tsis yog - phais kev cuam tshuam raukab mob cataractsthiabntshav qab zib retinopathy.
Kev Tshawb Fawb Txog Tshuaj: Siv los tsim thiab sim cov txheej txheem tshiab ocular xa khoom (xws li, nanoparticle carriers, therapeutic contact lenses) for sustained carnosine release.
Neuroscience & Aging Research
Oxidative Stress Models: Siv los tshawb xyuas kev tiv thaiv oxidative puas tsuaj hauv cov kab mob neuronal thiab microglial cell.
Neuroinflamation Studies: Siv rau hauv cov qauv los kawm txog kev hloov pauv ntawm txoj kev mob hauv lub hlwb.
Dermatology & Cosmetic Science Research
Daim tawv nqaij laus qauv: Kawm txog nws cov teebmeem ntawm kev tiv thaiv cov tawv nqaij thiab cov khoom siv (xws li collagen) los ntawm UV- ntxias thiab hnub nyoog- cuam tshuam oxidative puas tsuaj.
Biochemical & Metabolic Studies
AGE Inhibition Assay: Siv los tshawb fawb qhov inhibition ntawm protein glycation thiab nws cov txiaj ntsig pathological.
Enzyme Stability Studies: Ua haujlwm ua qauv sib xyaw kom nkag siab qhov cuam tshuam ntawm acetylation ntawm peptide stability tiv thaiv enzymatic hydrolysis.
Cov lus nug nquag nug (FAQ)
Q: N-Acetyl-L-carnosine siv rau hauv qhov muag tee yog dab tsi?
A: Hauv kev tshawb fawb ophthalmic thiab kev tsim khoom, nws yog siv los ua cov khoom muaj nyob rau hauv lubricant qhov muag poob formulations. Nws lub luag haujlwm yog raws li qhov kev xav tias, raws li qhov ruaj khov carnosine prodrug, nws tuaj yeem xa cov tshuaj tiv thaiv antioxidant thiab tiv thaiv -glycation kev ua haujlwm rau lub ntsej muag ntawm lub qhov muag thiab lub qhov muag sab hauv, muaj peev xwm hais txog cov xwm txheej cuam tshuam nrog hnub nyoog - cuam tshuam lub lens hloov.
Q: Puas yog N-Acetyl-L-carnosine tsuas yog ib daim ntawv ruaj khov ntawm L-carnosine?
A: Yog, qhov ntawd yog nws qhov txiaj ntsig tseem ceeb. Cov pab pawg acetyl ua rau nws qeeb qeeb los ntawm enzyme carnosinase, tso cai rau nws mus cuag cov ntaub so ntswg thiab muab kev tso tawm ntawm L-carnosine, thaum L-carnosine nws tus kheej yog metabolized sai hauv cov hlab ntsha.
Q: Puas muaj tej yam kev mob tshwm sim los yog kev txhawj xeeb txog kev nyab xeeb?
A: Hauv kev tshawb fawb soj ntsuam luam tawm ntawm kev siv ophthalmic, N-Acetyl-L-carnosine qhov muag tau raug tshaj tawm thiab- zam. Txawm li cas los xij, raws li kev tshawb fawb - qib tshuaj, nws tsis yog npaj rau tib neeg noj lossis siv kho yam tsis muaj kev tsim tshuaj thiab kev pom zoo. Kev nyab xeeb rau ib daim ntawv thov tshwj xeeb yuav tsum tau txiav txim siab los ntawm kev tshawb xyuas nruj.
Q: Dab tsi yog qhov pom zoo khaws cia rau cov hmoov?
A: Yuav kom muaj kev ruaj ntseg thiab purity, nws yuav tsum tau khaws cia desiccated ntawm -20℃thiab tiv thaiv los ntawm lub teeb.
Tiv tauj peb
Txhim kho koj qhov kev tshawb fawb nrog siab -purityN-Acetyl-L-carnosine Powder (CAS 56353-15-2), lub ntsiab lus tseem ceeb rau kev kawm oxidative kev nyuaj siab, kev laus, thiab lub hom phiaj xa khoom.
Hu rau peb pab neeg muag khoom hnub no rau:
- Thov ibCertificate of Analysis (CoA)thiab cov lus qhia ntxaws.
- Tham txog koj qhov tshwj xeebkev tshawb fawb lossis kev tsim khoom sivxav tau.
- Nug txogtus nqi thiab muajrau ntau qhov ntau.
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E-mail:ella.zhang@huilinbio-tech.com.
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