Taw qhia
Linaclotide(CAS 851199-59-2) yog ib qho hluavtaws 14-amino acid peptide tsim nrog peb daim ntawv cog lus disulfide, tsim los ua guanylate cyclase-C (GC-C) receptor agonist[1]. Nws muaj feem cuam tshuam nrog cov tsev neeg guanylin peptide tshwm sim thiab tau kawm ntau ntxiv rau nws lub luag haujlwm hauv kev hloov kho cov kua dej hauv plab hnyuv thiab qhov mob qhia txoj hauv kev.[2]. Raws li kev tshawb fawb sib xyaw, nws muab kev nkag siab zoo rau hauv plab hnyuv physiology thiab receptor signaling mechanisms.
Physicochemical Properties
| Khoom | Kev piav qhia |
|---|---|
| Khoom npe | Linaclotide |
| Yam khoom tshwm | Dawb rau tawm -dawb hmoov |
| Molecular Formula | C₅₉H₇₉N₁₅O₂₁S₆ |
| Molecular Luj | 1526.8 g / mol |
| CAS Nr | 851199-59-2 |
| Purity (HPLC) | >99.0% |
| Txee lub neej | 36 lub hlis raws li pom zoo cia |
| Solubility | Soluble hauv dej los yog dilute acetic acid |
| Cia | Khaws ntawm -20 degree, tiv thaiv lub teeb thiab noo noo |
Yam ntxwv
- Siab Purity: >99.0% txheeb xyuas los ntawm HPLC thiab LC-MS
- Kev ruaj ntseg: Ua kom ruaj khov raws li kev pom zoo cia
- Synthetic Keeb Kwm: Ua kom zoo sib xws thiab zam cov kab mob lom
- Qib tshawb fawb: Haum rau hauv vitro thiab tsiaj qauv kev kawm
Cov txiaj ntsig muaj peev xwm (Kev Tshawb Fawb Kev Tshawb Fawb)
Nco tseg: Cov kev nkag siab no yog muab los ntawm kev tshawb fawb txog kev tshawb fawb ua ntej. Cov khoom no yog siv rau kev tshawb fawb nkaus xwb thiab tsis yog rau tib neeg noj.
Cov kev tshawb fawb tshawb fawb tau pom ntau yam nthuav dav ntawm Linaclotide[2,3]:
- Receptor Activation: Ua raws li lub zog agonist ntawm guanylate cyclase-C (GC{1}}C) receptors hauv plab hnyuv epithelial hlwb
- Fluid Secretion Modulation: Ua kom cov qib intracellular cGMP, ua kom cov kua dej tso tawm kom zoo
- Pain Signaling Research: Pom muaj peev xwm kawm txog kev mob visceral hauv kev sim ua qauv
- Ion Transport Studies: Siv tau rau kev soj ntsuam cov tshuaj chloride thiab bicarbonate secretion mechanisms
Daim ntawv thov
Linaclotide yog siv rau hauv ntau daim ntawv thov kev tshawb fawb suav nrog[1,3]:
- Kev tshawb nrhiav plab hnyuv: Kawm txog cov kua dej hauv plab hnyuv thiab cov txheej txheem motility
- Receptor Signaling Studies: Tshawb xyuas GC-C receptor activation thiab downstream teebmeem
- Kev Tshawb Fawb Txog Tshuaj: Ua hauj lwm raws li ib qho kev sib txuas rau kev txhim kho plab hnyuv
- Physiological Studies: Tshawb nrhiav ion thauj mechanisms hla cov kab mob epithelial
- Kev tshawb fawb mob: Tshawb xyuas qhov mob visceral signaling txoj hauv kev sim ua qauv
OME kev pabcuam
Ntim & Shipping
Daim ntawv pov thawj
Cov lus nug nquag nug (FAQ)
Q: Puas yog Linaclotide pom zoo rau tib neeg siv?
A: Thaum cov tshuaj formulations muaj nyob, cov khoom no yog nruj me ntsis rau kev tshawb fawb lub hom phiaj nkaus xwb.
Q: Qhov kev xa khoom thiab kev cia khoom yog dab tsi?
A: Cov khoom raug xa nrog cov pob khoom txias thiab yuav tsum khaws cia ntawm -20℃thaum tau txais.
Q: Kuv puas tuaj yeem thov cov ntaub ntawv tshuaj ntsuam xyuas?
A: Yog, Daim Ntawv Pov Thawj Kev Ntsuam Xyuas muaj nyob rau ntawm kev thov rau kev tshawb fawb pov thawj.
Q: Koj puas muab kev cai synthesis?
A: Yog, kev cai synthesis thiab bulk ntau muaj rau kev tshawb fawb lub hom phiaj.
Yuav tiv tauj peb li cas?
Yog tias koj xav tau cov khoom no rau koj cov kev xav tau tshawb fawb, thov hu rau peb ntawmella.zhang@huilinbio-tech.comlos tham txog kev tsim khoomLinaclotide Peptide rau kev tshawb fawblub hom phiaj.
Cov ntaub ntawv
[1] National Center for Biotechnology Information. PubChem Compound Summary for CID 16140508, Linaclotide. Tau txais los ntawm https://pubchem.ncbi.nlm.nih.gov/compound/Linaclotide
[2] Bryant, AP, & Busby, RW (2010). Linaclotide: ib qho kev taw qhia tshiab hauv kev kho mob plab plob tsis so tswj nrog cem quav. Kev xav tam sim no hauv Kev Tshawb Fawb Tshuaj, 11(5), 572-580.
[3] Eutamene, H., & Bueno, L. (2007). Lub luag haujlwm ntawm probiotics hauv kev kho qhov txawv txav ntawm colonic flora induced los ntawm kev ntxhov siab. Ib., 56(11), 1495-1497.
Tsis lees paub
Cov khoom no yog npaj rau kev tshawb fawb lub hom phiaj nkaus xwb nyob rau hauv lub chaw kuaj. Nws tsis yog npaj rau kev kuaj mob, kho, lossis siv tib neeg. Nws yog tus neeg yuav khoom lub luag haujlwm los txheeb xyuas kev ua raws li tag nrho cov cai hauv zos, xeev, tsoomfwv, thiab thoob ntiaj teb txog kev muaj thiab siv cov khoom no. Xi'an Huilin Biological Technology Co., Ltd. xav tias tsis muaj kev lav phib xaub rau kev siv tsis raug, kev tuav tsis raug cai, lossis kev puas tsuaj los ntawm kev siv cov khoom no.
Cim npe nrov: Linaclotide hmoov, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, ntuj, zoo, Tshuag, kev muag
