Taw qhia rau Citric Acid Monohydrate
Citric Acid Monohydratesawv cev rau hydrated crystalline daim ntawv ntawm dav siv organic acid, incorporating ib tug dej molecule ib citric acid molecule nyob rau hauv nws siv lead ua lattice. Cov monohydrate no tau txais los ntawm kev tswj hwm crystallisation los ntawm chilled concentrated solutions, yielding free-flowing crystals uas tsis muaj ntxhiab kiag li thiab cov dej-soluble heev. Cov qauv tsim qauv-C₆H₈O₇·H₂O- sib piv nrog rau daim ntawv tsis muaj dej C₆H₈O₇, muab cov mis hnyav dua thiab txo qis acid zog ntawm qhov hnyav-rau-hnyav.
Cov monohydrate version muaj qhov ua tau zoo ntawm kev tuav pov hwm: nws nthuav tawm qhov hygroscopicity tsawg dua li nws cov khoom siv tsis muaj dej thaum khaws cia rau hauv cov av ntub, uas txhais tau hais tias cov yam ntxwv zoo tshaj plaws thiab txo cov caking thaum ua haujlwm. Nrog rau qhov kev sib cais ntawm 1,630 g / L hauv dej ntawm 20 degree, nws muab qhov tshwj xeeb sai solubilisation -ib qho tseem ceeb rau cov hmoov dej haus, effervescent granulations, thiab kua syrup systems. Thermal raug tshaj 40℃los yog ntev kev sib cuag nrog huab cua qhuav tawm ntawm cov dej crystallisation, hloov cov khoom mus rau lub xeev anhydrous. Citric acid yog ib qho tshwm sim metabolite uas pom muaj ntau hauv cov txiv hmab txiv ntoo citrus thiab ua haujlwm tseem ceeb hauv lub voj voog Krebs, tswj hwm lub zog tsim los ntawm carbohydrates, rog, thiab cov proteins. Kev tswj hwm kev lees paub yog tsim tau zoo: FDA lees paub tias nws yog GRAS, thiab EU kev tso cai tau tso cai raws li Txoj Cai (EC) Tsis muaj 1333/2008, nrog JECFA muab "tsis txwv" ADI rau citric acid thiab nws cov ntsev.
Physical & Chemical Parameters
| Parameter | Specification |
|---|---|
| Qhov tshwm sim | Dawb los yog xim tsis muaj ntxhiab, tsis muaj ntxhiab, crystalline hmoov los yog granules |
| Assay (C₆H₈O₇, xam raws li cov dej tsis muaj dej) | 99.5% – 100.5% |
| Dej ntawm Crystallisation (Karl Fischer) | 7.5% – 8.8% |
| Sulfated tshauv | Tsawg dua lossis sib npaug li 0.05% |
| Chloride (Cl) | Tsawg dua lossis sib npaug li 0.005% |
| Sulfate (SO₄) | Tsawg dua lossis sib npaug li 0.015% |
| Oxalate | Kev xeem dhau (tsawg dua lossis sib npaug li 100 mg / kg) |
| Npaj Carbonizable Khoom | xeem dhau |
| Lead (Pb) | Tsawg dua lossis sib npaug li 0.5 mg / kg |
| Arsenic (As) | Tsawg dua lossis sib npaug li 1.0 mg / kg |
| Mercury (Hg) | Tsawg dua lossis sib npaug li 0.1 mg / kg |
| Solubility hauv dej | 1,630 g / L ntawm 20 degree |
| Melting Point | 135-152℃(decomposition) |
| pH (1% aqueous tov) | 2.2 – 2.5 |
| Bulk Density (tus qauv) | 0.75 - 0.85 g / mL |
| Particle Loj | 100% txog 40 mesh; customizable rau 80/100 mesh |
| Qhov ntom | 1.542 g / cm³ ntawm 18 degree |
Cov txiaj ntsig ntawm citric acid
- Rapid Dissolution Performance:Nrog rau solubility ntawm 1,630 g / L ntawm 20 degree, daim ntawv no monohydrate dissolves sai dua li cov anhydrous version, xa ceev acidification thiab tsw tso tawm nyob rau hauv instant khoom.
- Txo cov dej noo khaws cia:Tsawg hygroscopicity nyob rau hauv cov av noo txhais tau hais tias tsawg dua caking thiab zoo dua lub sij hawm ntev flowability thaum lub sij hawm cia thiab manufacturing khiav.
- Zoo tshaj Chelating zog:Ua zoo khi hlau ions zoo li hlau thiab tooj liab, tiv thaiv oxidative rancidity, xim fading, thiab off-saj txoj kev loj hlob nyob rau hauv cov zaub mov formulated.
- Ntuj Antimicrobial Action:pH txo qis inhibits spoilage kab mob thiab cov kab mob pathogenic, ua rau cov khoom khaws cia yam tsis muaj cov khoom siv hluavtaws.
- pH Modulation & Buffering:Muab cov kua qaub meej tswj thoob plaws ntau yam khoom noj, dej haus, thiab kev siv tshuaj.
- Kev them nyiaj yug Antioxidant:Tshem tawm cov dawb radicals thiab tiv thaiv rhiab cov khoom xyaw los ntawm oxidative kev puas tsuaj hauv cov tshuaj pleev ib ce thiab tshuaj formulations.
- Mineral Absorption Enhancement:Hauv cov ntawv thov pub tsiaj, nws txhawb kev siv cov khoom noj calcium zoo dua, txhawb kev loj hlob ntawm pob txha thiab kev loj hlob.
- Calcium-Chelating Properties:Cov tshuaj tiv thaiv coagulant los ntawm kev khi calcium ions- muaj txiaj ntsig hauv qee qhov chaw kho mob thiab chaw kuaj mob.
- Txhim kho kev ua tau zoo:Dawb-flowing crystalline xwm ua kom zoo ib yam tshuaj, sib tov, thiab ntsiav tshuaj kev ua tau zoo nyob rau hauv high-ceev ntau lawm kab.
- Versatile Compatibility:Kev ua haujlwm zoo thoob plaws pH ntau yam thiab tseem sib xws nrog feem ntau cov khoom noj, dej haus, thiab cov khoom xyaw tshuaj.
Citric Acid siv rau dab tsi?
- Kev tsim dej haus:Acidification ntawm carbonated dej qab zib, kua txiv hmab txiv ntoo, nectars, dej haus kis las, thiab hmoov instant mixes qhov twg sai sai yog qhov tseem ceeb.
- Confectionery & Khoom qab zib:Imparts tangy tsw profiles nyob rau hauv gummies, nyuaj candies, sherbets, jellies, thiab dej ices.
- Pharmaceutical Granulation:Nyiam excipient rau effervescent granulations thiab qhuav syrup formulations yuav tsum tau ceev disintegration thiab dissolution.
- Liquid Pharmaceuticals:Muaj nuj nqi raws li tsis muaj, preservative, thiab tsw enhancer nyob rau hauv lub qhov ncauj syrups, ncua kev kawm ntawv, thiab cov me nyuam tee.
- Kev npaj tshuaj pleev ib ce:Ua raws li pH adjuster, me me exfoliant, thiab antioxidant booster nyob rau hauv cream, serums, lotions, thiab da dej khoom.
- Tsev & Cov Khoom Siv Hluav Taws Xob:Tus neeg saib xyuas kom zoo rau cov kav dej, lub tshuab kas fes, thiab cov tshuab ntxuav tais diav; tivthaiv hauv dej softeners thiab xeb tshem tawm.
- Tsiaj Pub Additive:Ua hauj lwm raws li tus neeg tswj xyuas acidity thiab preservative (E330) rau pub thoob plaws txhua hom tsiaj thiab pab pawg hnub nyoog.
- Wine & Cider Production:Kho acidity thiab stabilizes musts thiab tiav wines; kuj ua hauj lwm hauv cov txheej txheem kua txiv kom meej.
- Kev Tshawb Fawb & Kev Siv Chav Ua Haujlwm:Kev npaj citrate buffers rau cov kev tshawb fawb platelet, intravital microscopy, thiab cov txheej txheem radiochemical labeling.
Certificate of Analysis (COA)
Lus Cim: Tus neeg sawv cev COA rau Citric Acid Monohydrate Powder yog qhia hauv qab no. COA tiag tiag rau txhua pawg yog muab thaum xa khoom.
| Cov khoom kuaj | Specification | Yam tshwm sim |
|---|---|---|
| Qhov tshwm sim | Dawb los yog tsis muaj xim crystalline granules / hmoov | Ua raws |
| Kev txheeb xyuas (A, B) | xeem dhau | Ua raws |
| Assay (C₆H₈O₇, tsis muaj dej hauv paus) | 99.5% – 100.5% | 99.7% |
| Dej ntawm Crystallisation (KF) | 7.5% – 8.8% | 8.1% |
| Sulfated tshauv | Tsawg dua lossis sib npaug li 0.05% | 0.02% |
| Chloride | Tsawg dua lossis sib npaug li 0.005% | <0.002% |
| Sulfate | Tsawg dua lossis sib npaug li 0.015% | <0.005% |
| Oxalate | xeem dhau | Hla |
| Npaj Carbonisable Khoom | xeem dhau | Hla |
| Coj | Tsawg dua lossis sib npaug li 0.5 mg / kg | <0.1 mg/kg |
| Arsenic | Tsawg dua lossis sib npaug li 1.0 mg / kg | <0.2 mg/kg |
| Mercury | Tsawg dua lossis sib npaug li 0.1 mg / kg | <0.05 mg/kg |
| Particle Loj (40 mesh) | Ntau dua lossis sib npaug li 95% dhau los | 98% |
| Tag Nrho Phaj suav | Tsawg dua lossis sib npaug li 1,000 CFU / g | <50 CFU/g |
| Poov & Pwm | Tsawg dua lossis sib npaug li 100 CFU / g | <10 CFU/g |
| E. coli | Tsis zoo | Tsis zoo |
| Salmonella | Tsis zoo (rau 25 g) | Tsis zoo |
| Xaus | - | Ua raws li USP / FCC / EP monographs |
Cov lus nug nquag nug (FAQ)
Q: Cov ntawv monohydrate txawv li cas ntawm cov kua qaub citric acid hauv kev siv tswv yim?
A: Cov monohydrate (CAS 5949-29-1) muaj 7.5% - 8.8% dej ntawm crystallisation, muab nws qhov hnyav dua molecular thiab qis acid zog ib gram. Nws qhov kev ua tau zoo tseem ceeb yog txo qis kev nqus dej thaum lub sijhawm cia, uas txo qis caking thiab khaws cia flowability. Nws tseem yaj sai dua hauv dej (1,630 g / L ntawm 20 degree), ua rau nws mus rau kev xaiv rau effervescent granulations, syrups, thiab instant haus hmoov. Xaiv cov monohydrate thaum tawg sai thiab yooj yim tuav yog qhov tseem ceeb; xaiv anhydrous thaum ya raws rhiab heev thiab siab tshaj plaws acid concentration ib chav tsev qhov hnyav yog qhov tseem ceeb.
Q: Dab tsi yog USP / FCC specifications rau cov khoom no?
A: USP thiab FCC cov qauv xav tau: kev soj ntsuam 99.5% - 100.5% (anhydrous hauv paus), dej ntawm crystallisation 7.5% - 8.8%, sulphated tshauv Tsawg dua lossis sib npaug li 0.05%, lead Less dua lossis sib npaug rau 0.5 mg / kg, thiab dhau kev sim rau oxalate, chloride, thiab chlorides. Peb cov khoom ua tau raws li tag nrho cov qauv no.
Q: Daim ntawv no puas haum rau daim ntawv thov effervescent?
A: Yog-tshwj xeeb tshaj yog rau effervescent granulations qhov twg sai sai yog qhov tseem ceeb. Rau cov ntsiav tshuaj effervescent, anhydrous feem ntau nyiam rau cov kua qaub ntau dua ib ntsiav tshuaj; rau granules, monohydrate xa sai solubilization.
Q: Nws puas tuaj yeem ua haujlwm raws li kev khaws cia?
A: Yog. Los ntawm kev txo cov khoom pH, nws tsim cov xwm txheej tsis zoo rau cov kab mob spoilage. Nws kuj tseem chelates hlau ions uas yuav txwv tsis pub oxidative degradation, pab txhawb nqa lub neej ntev.
Q: Daim ntawv thov tshuaj twg yog siv rau?
A: Feem ntau siv xws li excipient nyob rau hauv effervescent granules, tsis nyob rau hauv syrups thiab qhov ncauj kev daws teeb meem, preservative/acidulant nyob rau hauv cov kua formulations, thiab tsis npaj rau platelet kev tshawb fawb thiab radiochemical labelling.
Q: Nws puas muaj kev noj haus lossis kev noj qab haus huv?
A: Tshaj li nws txoj haujlwm thev naus laus zis, citric acid txhim kho cov ntxhia hauv bioavailability (tshwj xeeb yog calcium), txhawb cov pob txha noj qab haus huv los ntawm kev siv calcium zoo dua, nthuav tawm cov kev ua haujlwm antioxidant, thiab muaj cov khoom tiv thaiv kab mob ntawm calcium chelation.
Peb Qhov Zoo
Koj tus kws tshaj lij kev tsim khoom & Sourcing tus khub
Peb yog ntau tshaj li tus neeg xa khoom - peb yog cov khoom lag luam sib txuas sib txuas rau siab - cov khoom xyaw zoo, cov qauv kev cai, thiab cov khoom tiav thoob plaws ntau qhov kev lag luam.
Nrog rau ntau xyoo ntawm kev paub hauv cov nroj tsuag extracts, khoom noj khoom haus additives, cosmetic raw cov ntaub ntawv, thiab cov khoom noj khoom haus, peb pab neeg coj cov kev txawj ntse txawj ntse thiab kev ua lag luam kev pom zoo rau txhua qhov kev koom tes.
01. Ntau yam khoom lag luam
Peb muab ntau yam khoom lag luam, suav nrog cov khoom noj khoom haus ntxiv, cov khoom siv cog qoob loo, txiv hmab txiv ntoo & zaub hmoov, tshuaj pleev ib ce, thiab cov khoom xyaw ua zaub mov.
- Raw Khoom:High -cov khoom xyaw purity rau zaub mov, dej haus, ntxiv, thiab kev siv tshuaj pleev ib ce.
- Cov khoom tiav:Hauv -tsev tsim cov tshuaj ntsiav, softgels, gummies, kua tee, thiab hmoov sib tov.
- Label Design & Ntim:Kev cai branding tailored rau koj lub hom phiaj ua lag luam.
- Formulation & R & D:Cov kws tshaj lij kev txhawb nqa los tsim cov kev cai sib xyaw, cov qauv tsim muaj, thiab cov khoom tsim tshiab.
- Ntiaj teb no Logistics:Txhim khu kev xa khoom, cov ntaub ntawv, thiab kev txhawb nqa kev lis kev cai.
04. Kev Ua Haujlwm Zoo
Kev nruj nruj raws li cGMP cov qauv thiab tag nrho cov kev cai pob tshab. Peb nyob twj ywm tam sim no nrog cov kev cai thoob ntiaj teb, suav nrog FDA GRAS, EFSA, thiab lwm yam kev cai hauv cheeb tsam, kom ntseeg tau tias koj cov khoom ua tau raws li cov qauv kev nyab xeeb siab tshaj plaws thiab ua raws.
Yuav tiv tauj li cas
Npaj rau qhov chaw zooCitric Acid Monohydrate hmoovrau koj cov zaub mov, dej haus, los yog tshuaj formulations?
Thov hu rau peb ntawmella.zhang@huilinbio-tech.com.
Cov ntaub ntawv
1. Joint FAO/WHO Expert Committee on Food Additives (JECFA). Citric acid. Hauv:Compendium ntawm Food Additive Specifications. 53rd JECFA, 1999. FAO JECFA Monographs 1. Additive-135. Muaj nyob online:https://www.fao.org/fileadmin/user_upload/jecfa_additives/docs/Monograph1/Additive-135.pdf
2. Citric Acid txhawb kev tiv thaiv kab mob los ntawm kev hloov kho lub plab hnyuv
International Journal of Molecular Sciences. 2024; 25(2): 1239. doi: 10.3390/ijms25021239
Txoj kev tshawb no qhia tau hais tias citric acid txhim kho txoj hnyuv plab zom mov, inhibits influenza virus replication, thiab boosts plab hnyuv muaj nuj nqi.
PubMed:https://pubmed.ncbi.nlm.nih.gov/38256224/| PIB: 10817003
3. EFSA Kev Tshawb Fawb Txog Kev Tshawb Fawb: Rov ntsuam xyuas dua ntawm Citric Acid (E 330) ua zaub mov ntxiv
EFSA Vaj Huam Sib Luag ntawm Zaub Mov Ntxiv thiab Flavorings (FAF). Rov ntsuam xyuas ntawm acetic acid, lactic acid, citric acid, tartaric acid, mono- thiab diacetyltartaric acid, sib xyaw acetic thiab tartaric acid esters ntawm mono- thiab diglycerides ntawm fatty acids (E 472a-f) ua zaub mov additives.EFSA Journal. 2020; 18(3): 6032. doi: 10.2903/j.efsa.2020.6032
Lub Vaj Huam Sib Luag xaus lus tias xav txog qhov kev kwv yees raug, tsis muaj kev txhawj xeeb txog kev nyab xeeb rau citric acid ntawm nws cov lus qhia txog kev siv thiab kev siv qib.
Saib hauv online:https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2020.6032
Tsis lees paub
Cov khoom no yog tsim los rau kev tsim, kev tsim, thiab kev ua haujlwm ntxiv nkaus xwb. Nws tsis yog rau tib neeg noj raws li cov khoom tiav. Cov lus hais txog cov txiaj ntsig kev noj qab haus huv yog ua raws li kev tshawb fawb txog zaub mov noj thiab luam tawm cov kev tshawb fawb soj ntsuam, thiab tsis yog tsim los kuaj, kho, kho, lossis tiv thaiv kab mob.
Cim npe nrov: citric acid monohydrate hmoov, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, ntuj, zoo, Tshuag, kev muag
