Lub hauv paus rau phau ntawv
Benfotiamine hmoovPuas yog cov khoom siv hluavtaws, rog - soluble derivative ntawm thiamine (vitamin B1). Renowned rau nws zoo tshaj plaws bioavailability piv rau dej- s soluble thiamine thiafine hauv thiamine ntxiv. Los ntawm kev sib txawv ntawm cov xovtooj ntawm cell, benfotiamine zoo li txhawb nqa cov hlab ntsha Thiamine, uas tseem ceeb rau cov ntshav hauv qab cov ntshav siab[1]Cov. Nws yog lub pob kws ua kom muaj cov khoom xyaw ua haujlwm siab heev thiab metabolic kev noj qab haus huv.
Biochemical & Cov tawv nqaij lub cev
| Chaw ua uas tsis tau haus | Kev qhia tshwj xeeb |
|---|---|
| Cas Tsis tau. | 22457-89-2 |
| Molecular Cov Qauv | C₁₉h₂₃n₄o₆ps |
| Molecular hnyav | 466.45 G / Mol |
| Kev tshwm sim | Dawb rau tawm -} e} crystalline hmoov |
| Assisy (hplc) | Ntau dua los yog sib npaug rau 98.0% |
| So | Soluble hauv lipids thiab organic kuab tshuaj; Qes solubility hauv dej. |
Mechanism ntawm Kev Ua: Cov Bioavailotable precursor
Qhov tshwj xeeb ua tau ntawmBenfotiamineStems los ntawm nws cov kws muag tshuaj tshwj xeeb thiab nws cov kev ua ntawm tus yuam sij metabolic:
- Zoo tshaj cellular uptake:Tsis zoo li dej - soluble thiamine, uas yuav tsum muaj kev thauj khoom, benfotiamine qhov chaw tso cai rau nws kom muaj kev sib txawv thiab ua kom zoo rau hauv cov hlwb thoob plaws lub cev.
- Kev ua haujlwm ntawm sab hauv:Ib zaug hauv lub xov tooj ntawm tes, enzymes hu ua phosphatases hloov benfotiamine rau hauv cov nquag Thoj (cov vitamins (cov vitamins
- Transkedolase qhib & glycation pathwation inhibition:Qhov no yog nws txhais tau txheej txheem. Benfotiamine potently aczyme cabletolase. This enzyme redirects the harmful metabolites of glucose (fructose-6-phosphate and glyceraldehyde-3-phosphate) away from three major damaging pathways:
1. Kev ua tiav Glycation kawg - cov khoom (hnub nyoog) txoj hauv kev:Los ntawm kev txo cov txheej txheem ua ntej, benfotiamine tseem ceeb inhibits qhov kev tsim ntawm cov hnub nyoog, uas ua rau cov nqaij mos thiab mob[2].
2. Lub hexosamine txoj kev
3. Cov protein Kinase C (PKC) Txoj Kev
Qhov kev txiav txim tshwj xeeb no yuav pab tiv thaiv cov leeg, cov hlab ntsha, thiab lwm cov ntaub so ntswg los ntawm kev ua phem ntawm cov ntshav qab zib.
Cov txiaj ntsig tseem ceeb ntawm Benfotiamine
- Cov tsos mob neuropathy txhawb nqa:Clinically tau kawm rau nws txoj haujlwm hauv kev txhawb nqa kev noj qab haus huv, Benfotiamine tau siv los pab txo cov tsos mob ntshav qab zib, xws li kev kub ntxhov, hlawv, loog, thiab mob[3].
- Haib anti - Tus neeg sawv cev Glycation:Pab tiv thaiv cov protein thiab cov ntaub so ntswg los ntawm qab zib -}}}} Qhov tseem ceeb hauv kev ua haujlwm ua ntej thiab kev teeb meem tseem ceeb.
- Zoo dua bioavailability:Tsa cov ntshav thiab cov nqaij thiav thiab cov nqaij thiav thiab cov nqaij thiav kom zoo dua li cov qauv dej ...} soluble thiamoodide.
- Kev Tsim Kho Cellular:Ua ib qho tseem ceeb rau TPP, nws yog qhov tseem ceeb rau Mitochondrial muaj nuj nqi thiab hloov dua siab tshiab ntawm carbohydrates mus rau lub zog (ATP).
- Zuag qhia tag nrho cov leeg ntshav siab:Txhawb txoj kev pab cuam noj qab nyob zoo thiab muab cov tshuaj tiv thaiv kab mob antioxidant rau tag nrho cov leeg ntshav.
Benfotiamine vs. Thiamine
| Yam zoo | Benfotiamine | Thiavine HCL (Txheem B1) |
|---|---|---|
| So | Rog - soluble | Dej - soluble |
| Kev nqus | Passive diffusion; zoo heev. | Nquag thauj; txwv los ntawm saturation. |
| Bioavailability | Siab heev.Kev ua tiav cov ntshav siab dua thiab cov nqaij tawv. | Txheem.Cov ntaub qhwv qis dua. |
| Thawj siv | Kev txhawb nqa rau cov neuropathy, anti {- glycation, thiab siab {1} -}} kev kho tshuaj. | Vitamin B1 cov kev tiv thaiv thiab kev tiv thaiv tsis tsim nyog. |
| Lub tshuab | Kev ua kom muaj zog ntawm cov khoom lag luam rau kev tiv thaiv Glycation txoj hauv kev. | Txheem cofactor rau lub zog metabolism. |
Cov ntawv thov hauv kev lag luam
Benfotiamine hmoovyog cov khoom xyaw tseem ceeb rau kev npaj cov kev noj qab haus huv:
1. Kev Noj Qab Haus Huv & Nutraceuticals:
Cov qauv ua qauv rau cov tshuaj tiv thaiv kab mob ntshav qab zib.
Advanced Anti -}}}}}}}}} - glycation.
General cov hlab ntsha thiab cov kev txhawb nqa metanolic.
2. Tshuaj Nruab Nrab Nruab Nrab:Siv nyob rau hauv kev txhim kho thiab kev tsim khoom ntawm cov tshuaj - cov tshuaj muaj txiaj ntsig thiab metabolic noj haus.
3. Kev kuaj mob noj mov:Koom rau hauv cov khoom noj kho mob kho mob tshwj xeeb rau cov neeg mob uas muaj mob rau thiamine deficiency lossis cov teeb meem metabolism lossis cov teeb meem.
Cov Lus Nquag Nug (FAQ)
Q: Dab tsi yog benfotiamine siv rau?
A: Nws thawj qhov kev siv yog nyob rau hauv kev txhawb nqa cov hlab ntsha, tshwj xeeb tshaj yog rau cov tsos mob ntawm Neuropathy ntshav qab zib. Nws kuj yog siv rau nws cov haib anti {- glycation thaj chaw thiab los txhawb cov kev noj qab haus huv metall thiab cellular kev noj qab haus huv ntawm vitamin B1.
Q: Puas muaj cov kev mob tshwm sim?
A: Benfotiamine feem ntau zoo heev -}}}}}}}} Tsis muaj kev nyab xeeb. Cov kev mob tshwm sim muaj tsawg heev tab sis, hauv qee tus neeg, suav nrog kev chim me me. Nws muaj kev nyab xeeb ntau dua kev nyab xeeb ntau dua li dej - soluble Thiamine.
Q: Benfotiamine txawv li cas los ntawm cov vitamin tsis tu ncua B1 ntxiv?
A: Cov ntsiab lus tseem ceeb yog bioavailability thiab tshuab. Benfotiamine yog cov rog - soluble, cia nws ncav cuag ntau dua cov hlwb uas nws xav tau. Tsis tas li ntawd, nws tsis sib xws ua rau lub transneolase enzyme, muab cov txiaj ntsig tawm tsam cov kab tshoob kev puas tsuaj uas tus qauv thiav.
Q: Puas yog benfotiamine haus yeeb tshuaj lossis vitamin?
A: Benfotiamine yog hluavtaws derivative ntawm vitamin B1 (Thiamine). Nws yog txoj cai raws li kev noj haus kev noj haus ntxiv rau ntau lub tebchaws. Hauv qee thaj tsam, nws yuav yog cov tshuaj uas muaj tshuaj.
Tiv Tauj Peb
Txhawb nqa koj cov kev noj qab haus huv nrog rau cov bioavailotion zoo tshaj thiab tsom ntawmBenfotiamine hmoov (li 22457-89-2)Cov. Lub tswv yim zoo rau kev tsim kho cov hlab ntsha thiab cov khoom lag luam metabolic. Hu rau peb hnub no thov daim ntawv pov thawj ntawm kev tsom xam (COA), kev txhawb nqa kev sib tw, thiab cov lus sib tw.
E - email:ella.zhang@huilinbio-tech.com.
Ntawv Sawv cev
- Greb, A., & Bitsch, R. (1998). Sib piv cov xyoob ntawm ntau yam thiamine derivatives tom qab kev tswj hwm qhov ncauj.Cov Ntaub Ntawv Thoob Ntiaj Teb Hauv Chaw Kho Mob thiab Tshuaj Kho Mob, 36(4), 216-221.
- Hammas, HP, li al. (2003). Benfotiamine thaiv peb txoj kev loj ntawm hyperglycemic kev puas tsuaj thiab tiv thaiv kev sim mob ntshav qab zib retinopathy.Xwm Tshuaj, 9(3), 294-299.
- Stirban, A., li al. (2006). Benfotiamine tiv thaiv macro {4 4}}}}}}} endothelial dysfunction ua raws li cov khoom noj muaj mob oxfation nyob rau hauv cov tib neeg muaj ntshav qab zib hom 2.Ntshav qab zib tu, 29(9), 2064-2066.
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