Vanillin yog dab tsi?
Vanillin yog thawj cov tshuaj tsw qab ua lub luag haujlwm rau cov yam ntxwv tsw thiab ntxhiab ntawm vanilla. Nws yog ib qho organic phenolic aldehyde ib txwm tshwm sim hauv vanilla taum los ntawmVanilla planifolia yog ib qho yooj yim, Vanilla tahitensis, thiabVanilla pomponaorchids[3]. Vanillin kuj tuaj yeem tsim tawm los ntawm guaiacol lossis lignin, lossis los ntawm biotechnological fermentation siv cov khoom noj tshiab xws li ferulic acid, qabzib, lossis eugenol.[3].
Nyob rau hauv cov tshuaj pleev ib ce, vanillin yog dav siv raws li ib tugtshuaj tsw qabthiabdaim npog qhov ncauj, nrog rau INCI ua haujlwm ntawmMasking(txo los yog inhibiting tus ntxhiab los yog yooj yim saj ntawm ib yam khoom). Vanillin yog tam sim no nyob rau hauv kwv yees li 0.63% ntawm cov tshuaj pleev ib ce, nrog rau cov kev siv ntau tshaj plaws nyob rau hauv cov tshuaj pleev thaiv hnub di ncauj balms (9.97%), di ncauj lacquers thiab inks (7.48%), glosses (5.85%), thiab lipsticks (5.83%).[3].
Regulatory & Safety Overview
- FDA GRAS:Vanillin tau teev tseg raws li "Feem ntau Pom tau tias muaj kev nyab xeeb" (GRAS) los ntawm US FDA hauv qab 21 CFR 182.60 rau siv los ua cov khoom siv hluavtaws.[2].
- EU Kev Cai Cosmetics:Raws li Txoj Cai (EU) 2023/1545 hloov kho Txoj Cai (EC) No 1223/2009, vanillin raug cais raws li cov tshuaj tsw qab tsw. Nws yuav tsum tau tshaj tawm nyob rau hauv daim ntawv teev cov khoom xyaw thaum nws concentration tshaj0.001% tawm hauv - ntawm cov khoomlos yog0.01% hauv dej yaug-tawm cov khoom [3].
- Kev ntsuam xyuas CIR:Cov Khoom Siv Tshuaj Txhuam Hniav (CIR) Cov Kws Tshaj Lij Tshaj Lij tau soj ntsuam vanilla- cov khoom xyaw tau los thiab xaus lus tias 7 ntawm 9 cov khoom xyaw muaj kev nyab xeeb hauv cov tshuaj pleev ib ce tam sim no cov kev coj ua thiab kev siv zog thaum tsim los tsis yog -sensitizing[3]. Vanillin yogtsis paub daim tawv nqaij sensitizer [3].
- JECFA Kev Ntsuam Xyuas:Lub Koom Haum Koom Tes FAO / WHO Cov Kws Tshaj Lij Tshaj Lij rau Khoom Noj Ntxiv (JECFA) tau tshuaj xyuas vanillin hauv xyoo 2019 thiab tau tsim tias muajtsis muaj kev txhawj xeeb txog kev nyab xeeb ntawm cov khoom noj tam sim nothaum siv los ua tus neeg sawv cev flavoring[4].
Biochemical & Physical Parameters
| Parameter | Specification |
|---|---|
| INCI npe | VANILLIN |
| CAS Nr | 121-33-5 |
| EC Number | 204-465-2 |
| Molecular Formula | C₈H₈O₃ |
| Molecular Luj | 152.15 g / mol |
| Purity | Ntau dua lossis sib npaug li 99.0% |
| Qhov tshwm sim | Dawb mus daj daj crystalline hmoov los yog koob |
| tsw | Ntxiv qab zib, creamy vanilla-zoo li |
| Melting Point | 81-83 degree |
| Boiling Point | ~ 285 degree |
| Flash Point | 212 ° F (100 ° F) |
| Solubility hauv dej | 1 g / 100 mL ntawm 25 degree |
| Solubility | Soluble hauv cawv, propylene glycol |
| Hnyav Hlau | Tsawg dua lossis sib npaug li 0.001% |
| Arsenic | Tsawg dua lossis sib npaug li 0.0003% |
| Poob rau ziab | Tsawg dua los yog sib npaug li 0.5% |
| Residue ntawm Ignition | Tsawg dua lossis sib npaug li 0.05% |
| log P | 1.208 |
| Txee lub neej | 24 lub hlis (tsis qhib, cia kom zoo) |
Mechanism ntawm Action & Metabolism
Vanillin siv nws cov txiaj ntsig zoo hauv kev siv tshuaj pleev ib ce los ntawm ob lub hauv paus txheej txheem:
1. Antioxidant Kev Ua Haujlwm
Vanillin muaj cov khoom muaj txiaj ntsig antioxidant uas pab tiv thaiv daim tawv nqaij los ntawm oxidative kev nyuaj siab. Nws ua haujlwm los ntawmtshem tawm cov dawb radicalsthiabinhibiting lipid peroxidation, yog li tiv thaiv kev puas tsuaj rau cellular proteins thiab lipids hauv daim tawv nqaij[3][5]. Vanillin tau raug lees paub tias muaj ntau yam tshuaj muaj txiaj ntsig, suav nrog tshuaj tua kab mob antioxidant, tshuaj tua kab mob, thiab tiv thaiv - cov dej num inflammatory[6][7]. Kev ua haujlwm antioxidant ntawm vanillin pab tswj qhov sib npaug ntawm pro-oxidant thiab antioxidant tiv thaiv, tiv thaiv cellular qauv los ntawm oxidative kev puas tsuaj[8].
2. Fragrance Masking
Vanillin ua haujlwm feem ntau yog adaim npog qhov ncaujnyob rau hauv cov tshuaj pleev ib ce formulations, txo los yog inhibiting undesirable tsw los yog saj ntawm lwm yam khoom xyaw[3]. Nws sov, qab zib, creamy vanilla aroma ua rau nws nyiam xaiv los txhim kho qhov kev xav ntawm daim tawv nqaij, kho daim di ncauj, tu plaub hau, thiab cov khoom siv tshuaj tsw qab. Lub compound cuam tshuam nrog olfactory receptors, muab qhov kev paub zoo nkauj uas tuaj yeem pab npog qhov tsw ntawm cov khoom xyaw nquag nrog cov ntxhiab tsw ntxim nyiam.[3].
Cov txiaj ntsig & Kev Ua Haujlwm Zoo
1. Cov txiaj ntsig kho tawv nqaij
Antioxidant tiv thaiv
Vanillin muaj cov tshuaj antioxidant uas pab tiv thaiv oxidation ntawm cov protein thiab lipids hauv daim tawv nqaij[3][5].
Neutralizing dawb radicals pab tiv thaiv daim tawv nqaij los ntawm ib puag ncig kev ntxhov siab xws li kev ua qias tuaj thiab UV raug, txhawb nqa lub ntsej muag hluas dua.[8].
Kev Ntsuas Kev Ntsuas
Muab qhov sov, qab zib, thiab qab ntxiag vanilla aroma uas txhim kho tag nrho cov kev paub ntawm cov khoom tu tawv nqaij, ua rau lawv txaus siab rau cov neeg siv khoom.[3].
2. Cov txiaj ntsig ntawm kev kho daim di ncauj
Vanillin yog dav siv nyob rau hauv di ncauj khoom, nrog rau di ncauj balms, glosses, thiab lipsticks, rau nws qab zib saj thiab qab ntxiag aroma.[3].
Ntawm qhov siab txog li 9.97% hauv cov tshuaj pleev thaiv hnub pleev di ncauj, nws zoo npog qhov saj thiab tsw ntawm lwm cov khoom xyaw thaum muab cov txiaj ntsig zoo.[3].
3. Kev tu plaub hau & Perfumery
Hauv cov khoom siv tu tus kheej, vanillin ntxiv qhov sov, qab zib rau cov tshuaj zawv plaub hau, tshuaj kho mob, thiab tshuaj tsw qab, txhim kho tus neeg siv lub siab xav.[3].
Nws ntev - aroma ntev ua rau cov khoom kom zoo nkauj ntxim nyiam thiab nco.
Daim ntawv thov
1. Cov txheej txheem ntawm daim tawv nqaij
| Yam khoom | Muaj nuj nqi | Pom zoo siv |
|---|---|---|
| Moisturizers & lotions | Cov tshuaj tsw qab, kev txhawb nqa antioxidant | 0.05–0.5% |
| Anti- creams & serums | Antioxidant kev tiv thaiv, kev hnov qab txhim kho | 0.1–0.5% |
| Suncare & tom qab- cov khoom siv hnub ci | Tshuaj tsw qab, npog | 0.1–1.0% |
| Ntsej muag ntsej muag & essences | Kev hnov lus zoo | 0.05–0.3% |
| Cleansers & Toners | Tshuaj tsw qab | 0.05–0.2% |
2. Lip Care Formulations
| Yam khoom | Muaj nuj nqi | Pom zoo siv[3] |
|---|---|---|
| Sunscreen di ncauj balm | Taste masking, fragrance | 0.5–10.0% |
| Lip gloss & di ncauj lacquer | Qab zib saj, qab ntxiag aroma | 1.0–7.5% |
| Daim di ncauj | Fragrance, saj txhim khu kev qha | 1.0–5.8% |
3. Kev tu plaub hau & Perfumery
| Yam khoom | Muaj nuj nqi | Pom zoo siv |
|---|---|---|
| Shampoos & conditioners | Tshuaj tsw qab | 0.05–0.5% |
| Cov tshuaj tsw qab zoo | Base / nruab nrab daim ntawv, sov vanilla tsw | 0.1–5.0% |
| Lub cev sprays & mists | Tshuaj tsw qab | 0.1–2.0% |
4. Cov lus qhia txog kev tsim
- Solubility:Vanillin yog soluble hauv cawv thiab propylene glycol, thiab soluble hauv dej (kwv yees li 1 g / 100 mL ntawm 25 degree). Ua ntej- dissolve nyob rau hauv ib tug haum hnyav ua ntej incorporating rau hauv dej-raws li formulations[1].
- pH stability:Stable nyob rau hauv formulations nrog pH 4.0-7.0. Vanillin yooj yim discolored thaum raug alkaline tshuaj (pH> 7.5).
- Kev ua:Ntxiv ntawm qhov kub thiab txias hauv qab 60℃kom khaws tau cov aromatic profile. Tsis txhob ua cua sov ntev.
- Storage Sensitivity:Vanillin yog yooj yim oxidized nyob rau hauv huab cua thiab tuaj yeem discolor thaum raug lub teeb. Tiv thaiv cov formulations tiav los ntawm lub teeb thiab cua siv opaque los yog amber ntim.
- Pom zoo siv:0.05-5.0% nyob rau hauv cov tshuaj pleev ib ce tiav formulations, nyob ntawm seb yam khoom thiab xav siv zog. Hauv cov khoom di ncauj, qhov siab dua (txog 10%) tau txais[3].
- EU Regulatory Limit: Must be declared on ingredient list when >0.001% in leave-on products or >0.01% hauv dej yaug-tawm cov khoom[3].
FAQ: Cov lus nug nquag nug
Q: Dab tsi yog qhov txawv ntawm ntuj, hluavtaws, thiab bio-fermented vanillin?
A:
- Ntuj vanillinyog muab rho tawm ncaj qha los ntawm vanilla taum (Vanilla planifolia yog ib qho yooj yim, Vanilla tahitensis, los yogVanilla pompona) [3].
- Synthetic vanillinyog chemically synthesized, feem ntau yog los ntawm guaiacol los yog lignin, thiab sau tias yog vanillin dag[3].
- Bio-fermented vanillinyog tsim los ntawm microbial fermentation siv cov khoom siv txuas ntxiv dua tshiab xws li ferulic acid (muab los ntawm cov roj nplej nplej) lossis qabzib, muab "natural" daim ntawv lo nrog kev tsim khoom ruaj khov.[3].
Tag nrho peb daim ntawv yog tshuaj zoo tib yam (C₈H₈O₃) thiab muaj tib yam kev nyab xeeb profile thiab kev ua haujlwm.
Q: Dab tsi yog EU txoj cai tswj hwm rau vanillin hauv tshuaj pleev ib ce?
A: Raws li Txoj Cai (EU) 2023/1545 hloov kho Txoj Cai (EC) Tsis muaj 1223/2009, vanillin raug cais raws li cov tshuaj tsw qab. Nws yuav tsum tau tshaj tawm nyob rau hauv daim ntawv teev cov khoom xyaw thaum nws cov concentration ntau tshaj 0.001% nyob rau hauv tawm- ntawm cov khoom los yog 0.01% nyob rau hauv yaug- tawm cov khoom[3].
Q: Puas yog vanillin pom zoo rau kev siv tshuaj pleev ib ce?
A: Yog. FDA teev vanillin raws li Kev Pom Zoo Pom Zoo (GRAS) hauv qab 21 CFR 182.60[2]. Cov Khoom Siv Tshuaj Txhuam Hniav Tshuaj Xyuas (CIR) Cov Kws Tshaj Lij Tshaj Lij tau soj ntsuam vanilla- cov khoom xyaw tau los thiab xaus lus tias 7 ntawm 9 cov khoom xyaw muaj kev nyab xeeb rau kev siv tshuaj pleev ib ce ntawm kev siv tam sim no ntau npaum li cas thaum tsim los tsis yog -sensitizing[3]. Lub Koom Haum Koom Tes FAO / WHO Cov Kws Tshaj Lij Tshaj Lij rau Cov Khoom Noj Ntxiv (JECFA) tau tsim nyob rau xyoo 2019 tias tsis muaj kev txhawj xeeb txog kev nyab xeeb ntawm cov khoom noj tam sim no thaum siv los ua cov tshuaj tsw qab[4]. Tsis zoo li ntau cov khoom xyaw tshuaj tsw qab, vanillin tsis yog ib qho kev paub txog ntawm daim tawv nqaij[3].
Q: Dab tsi yog qhov stability ntawm vanillin hauv formulations?
A: Vanillin ruaj khov nyob rau hauv ib txwm muaj tab sis muaj cov hauv qab no rhiab heev:
- Lub teeb-sensitive:Tej zaum yuav discolor thaum raug lub teeb; siv opaque / amber ntim
- Oxygen-sensitive:Yooj yim oxidized hauv huab cua; siv cov tshuaj antioxidants hauv formulations
- pH-sensitive:Yooj yim hloov xim thaum raug cov tshuaj alkaline (pH> 7.5); tswj pH 4.0-7.0
- Kub-sensitive:Ntxiv ntawm qhov kub thiab txias qis dua 60℃kom khaws cov ntxhiab tsw
Q: MOQ thiab lub sijhawm ua haujlwm yog dab tsi?
A: Txheem MOQ yog 25 kg (fiber nruas). Cov qauv (100-500 g) muaj rau kev sim. Lub sij hawm xa tuaj rau kev txiav txim lag luam feem ntau yog 2-3 lub lis piam tom qab kev pom zoo. Express shipping xaiv muaj rau cov qauv.
Q: Koj puas muab kev cai ntim khoom thiab daim ntawv lo?
A: Yog. Peb muab OEM ntim (piv txwv li, 1 kg, 5 kg, 10 kg, 25 kg) nrog rau cov ntawv sau ua ntau hom lus. Peb tuaj yeem tsim kev cai sib xyaw ua ke nrog vanillin nrog lwm cov khoom xyaw nquag.
Q: Cov ntaub ntawv tswj hwm dab tsi koj muab?
A: Peb muab COA, MSDS (Safety Data Sheet), Technical Data Sheet, allergen declaration, GMP statement, thiab raws li qhov kev thov, Kosher/Halal/Gluten-Daim ntawv pov thawj, IFRA daim ntawv ua raws cai, thiab cov ntaub ntawv tswj hwm rau lub teb chaws lub hom phiaj.
Q: Puas yog vanillin haum rau siv thaum so - ntawm cov khoom?
A: Yog lawm, tab sis nrog kev txiav txim siab ntawm EU daim ntawv lo ua xua. Vanillin yog siv dav hauv kev tawm mus - ntawm cov khoom xws li moisturizers, serums, thiab perfumes ntawm qhov ntau ntawm 0.05-0.5%. EU yuav tsum tau tshaj tawm allergen saum toj no 0.001%, uas yog yuav luag ib txwm tshaj ntawm kev ua haujlwm qib[3].
Q: Lub neej txee thiab kev pom zoo cia rau cov hmoov ntau yog dab tsi?
A: 24 lub hlis thaum khaws cia rau hauv lub thawv qub uas tsis tau qhib ntawm 2-8℃hauv qhov txias, qhuav, zoo- qhov cua nyob ib puag ncig, tiv thaiv tshav kub, lub teeb, noo noo, thiab oxygen[1]. Thaum qhib, siv tam sim ntawd thiab kaw kom nruj. Cov hmoov yuav clump yog tias raug cov av noo.
Q: Vanillin puas tuaj yeem siv rau hauv cov khoom siv hnub ci?
A: Yog. Vanillin yog siv nyob rau hauv cov khoom siv hnub ci, tshwj xeeb tshaj yog tshuaj pleev thaiv hnub di ncauj qhov chaw uas nws tau siv nyob rau hauv cov concentrations siab li 9.97%[3]. Nws cov khoom antioxidant tuaj yeem muab cov txiaj ntsig zoo tiv thaiv ntxiv los ntawm kev ua kom cov dawb radicals tsim los ntawm UV raug[8].
Vim li cas thiaj xaiv peb?
Koj tus kws tshaj lij kev tsim khoom & Sourcing tus khub
Peb yog ntau tshaj li tus neeg xa khoom - peb yog cov khoom lag luam sib txuas sib txuas rau siab - cov khoom xyaw zoo, cov qauv kev cai, thiab cov khoom tiav thoob plaws ntau qhov kev lag luam.
Cov kws tshaj lij
Nrog rau ntau xyoo ntawm kev paub hauv cov nroj tsuag extracts, zaub mov additives, cosmetic raw cov ntaub ntawv, thiab cov khoom noj khoom haus, peb pab neeg coj kev txawj ntse txawj ntse thiab kev ua lag luam kev pom zoo rau txhua qhov kev koom tes.
01
Ntau Yam Khoom Muag
Peb muab ntau yam khoom lag luam nrog rau cov khoom noj ntxiv, cov khoom siv cog qoob loo, txiv hmab txiv ntoo & zaub hmoov, cov khoom siv tshuaj pleev ib ce, thiab cov khoom xyaw ua zaub mov.
02
Ib -Stop Shop
Raw Khoom:High -cov khoom xyaw purity rau zaub mov, dej haus, ntxiv, thiab kev siv tshuaj pleev ib ce.
Cov khoom tiav:Hauv -tsev tsim cov tshuaj ntsiav, mos gels, gummies, kua tee, thiab hmoov sib tov.
03
Kev pabcuam OEM / ODM / OBM
Label Design & Ntim:Custom branding tailored rau koj lub hom phiaj kev lag luam.
Formulation & R & D:Cov kws tshaj lij kev txhawb nqa los tsim cov kev cai sib xyaw, cov qauv tsim muaj, thiab cov khoom tsim tshiab.
Ntiaj teb no Logistics:Txhim khu kev xa khoom, cov ntaub ntawv, thiab kev pabcuam kev lis kev cai.
04
Quality Assurance
Kev nruj nruj raws li GMP cov qauv thiab tag nrho cov kev cai pob tshab. Peb nyob twj ywm tam sim no nrog cov kev cai thoob ntiaj teb suav nrog FDA GRAS, EFSA, thiab lwm yam kev cai hauv cheeb tsam kom ntseeg tau tias koj cov khoom ua tau raws li cov qauv kev nyab xeeb siab tshaj plaws thiab ua raws.
05
Ua tam sim no
Npaj los koom nrog Vanillin Powder rau hauv koj cov tshuaj pleev ib ce tom ntej lossis kev kho tus kheej?
Tiv tauj peb hnub no rau:
- Certificate of Analysis (COA) thiab Material Safety Data Sheet (MSDS)
- Kev them nyiaj yug technical formulation
- Kev cai ntim cov kev xaiv
- Cov ntaub ntawv tswj hwm rau koj lub hom phiaj kev lag luam
- Cov qauv dawb rau kev sim
Thov hu rau peb ntawmella.zhang@huilinbio-tech.com.
Cov ntaub ntawv
- PubChem.Vanillin - Cov ntsiab lus sib xyaw (CID 1183). National Library of Medicine.
- US Food and Drug Administration.21 CFR 182.60 - Synthetic flavoring substances and adjuvants. Txoj Cai ntawm Tsoom Fwv Teb Chaws Txoj Cai, Title 21.
- INCI Kev zoo nkauj.VANILLIN - INCI Cov khoom xyaw Profile.
- Joint FAO/WHO Expert Committee on Food Additives (JECFA).Vanillin - Kev Ntsuam Xyuas Kev Ntsuam Xyuas. WHO Food Additives Series, 2019.
- Bora, G.Vanillin - Ntau tshaj Ib Tus Neeg Saib Xyuas Flavoring: Kev Ntsuam Xyuas Ntawm Nws Cov Khoom Siv Bioactive. Phau ntawv Journal of Pharmaceutical Negative Results, 2023; 14(S01): 78. DOI: 10.47750/pnr.2023.14.S01.78
- Oluwole, OS, et al.Vanillin: Ib qho khoom noj khoom haus ntxiv nrog ntau yam kev ua haujlwm lom neeg. European Journal of Medicinal Chemistry Reports, 2022; 5: 100055. DOI: 10.1016/j.ejmcr.2022.100055
- Bezerra, DP, et al.Vanillin: Kev tshuaj xyuas ntawm cov kev cia siab kho mob ntawm cov tshuaj tsw qab nrov. Kev nce qib hauv Cov Tshuaj Kho Mob, 2021; 21:1–17. PIB: 10.1007/s13596-020-00531-w
- Tai, A., et al.Antioxidative yam ntxwv thiab inhibition ntawm -melanocyte-stimulating hormone-stimulated melanogenesis ntawm vanillin thiab vanillic acid los ntawm Origanum vulgare. Kev sim tshuaj dermatology, 2010; 19(8): 742–749 : kuv. DOI: 10.1111/j.1600-0625.2010.01092.x
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