Taw qhia
Neotame hmoovyog ib tiam tom ntej -,siab - siv, tsis yog - khoom qab zibuas yog tshuaj tau los ntawm dipeptide ntawm aspartic acid thiab phenylalanine. Renowned rau nws qhov tshwj xeeb qab zib -7,000 mus rau 13,000 lub sij hawm sweeter dua sucrose (cov lus qab zib)-nws muab lub zog ua kom qab zib nrog kev siv tsawg heev[1]. Nws yog tsim los muab ib tughuv si, qab zib -zoo li sajtsis muaj iab los yog xim hlau aftertastes feem ntau txuam nrog lwm yam khoom qab zib. Pom zoo rau kev siv los ntawm cov koom haum tswj hwm loj suav nrog covUS FDA (2002)thiab suav nrog hauvTuam Tshoj GB 2760-2024Khoom noj khoom haus additive tus qauv, Neotame yog ntau yam khoom xyaw rau lub tswv yim tshiab, qis-calorie, thiab qab zib- cov khoom formulations dawb thoob ntiaj teb.
Biochemical & Physical Parameters
| Parameter | Nqe lus piav qhia / Specification |
|---|---|
| CAS Nr. | 165450-17-9 |
| E naj npawb | E 961 |
| Purity (HPLC) | Ntau dua lossis sib npaug li 98% (Tswj) |
| Molecular Luj | 378,46 g / mol |
| Solubility | Soluble hauv dej (~ 200.81 mM), ethanol, thiab DMSO. |
| Qab Zib Potency | 7, 000 - 13,000x sucrose; 30 - 60x aspartame. |
| Caloric nqi | Ua tau zoo tsis-caloric (<0.3 kcal/g). |
| Cia | Khaws rau hauv qhov chaw txias, qhuav (-20℃pom zoo rau kev ruaj ntseg mus ntev). |
| Txee lub neej | Txog li 3 xyoos nyob rau hauv kev cia khoom zoo. |
Mechanism ntawm Action
Yuav Ua Li Cas Qab Zib:
Neotame ua haujlwm los ntawmkhi nrog siab affinity rau tib neeg qab zib saj receptor (T1R2 / T1R3)ntawm tus nplaig[2]. Nws cov qauv molecular yog engineered kom haum txig rau hauv lub receptor lub khi qhov chaw, ua rau muaj zog neural teeb liab pom tau tias yog khaus qab zib, ntau dua sucrose los yog aspartame.[2].
Yuav Ua Li Cas Ua Hauv Lub Cev:
Ib qho txiaj ntsig tseem ceeb ntawm Neotame nyob hauv nwsnws tus kheej metabolic txoj kev, uas txawv heev ntawm nws cov thawj coj, aspartame:
1. Ester Hydrolysis: Lub hauv paus metabolic txoj kev yog hydrolysis ntawm methyl ester pawg los ntawm esterases dav, ua de-esterified Neotame thiab methanol me me.[3].
2. Thaiv Peptide Cleavage: Cov3,3-dimethylbutyl pawgtxuas nrog aspartyl moiety ua raws li qhov loj steric hindrance. Qhov no ua tau zoothaiv kev ua ntawm peptidasesuas feem ntau yuav rhuav tshem peptide daim ntawv cog lus ntawm aspartic acid thiab phenylalanine[3].
3. Qhov tshwm sim: Qhov kev thaiv no ua rauKev tso tawm tsawg kawg ntawm phenylalaninerau hauv cov hlab ntsha. Yog li, tsis zoo li aspartame,Neotame tsis xav tau daim ntawv ceeb toom rau cov tib neeg uas muaj phenylketonuria (PKU), ua kom muaj kev nyab xeeb dua rau cov neeg no[2].
Cov txiaj ntsig & qhov zoo
- Qab zib heev & Nqis -Kev ua tau zoo: Nws lub zog txawv tshaj plaw (ntau txhiab lub sijhawm sweeter dua qab zib) txhais tau tiasqib siv tsawg heev(feem ntau yog 0.001% - 0.1%), ua rau kom txuag tau tus nqi tseem ceeb hauv cov qauv[2].
- Clean Taste Profile: Muab ahuv si, qab zibtsis muaj qhov tsis xav tau iab, nws yog xim hlau, lossis licorice -zoo li aftertastes ntau nrog rau lwm cov khoom qab zib siab - siv cov khoom qab zib, txhim kho kev txais khoom[2].
- Txhim khu kev ruaj ntseg: Cov khoom pov thawjstability ntau dua aspartamenyob rau hauv nruab nrab pH tej yam kev mob thiab nyob rau hauv high kub, ua rau nws haum rau ntau yam kev siv, nrog rauci khoom thiab pasteurized dej haus[2].
- Ntau yam Compatibility: Chemically inert rau txo cov suab thaj (xws li, qabzib, fructose) thiab aldehyde -raws li flavour (xws li, vanilla, cinnamon), tso cai rau siv tau yooj yim nyob rau hauv complex zaub mov systems yam tsis poob qab zib los yog ua rau qab degradation.[2].
- Metabolic & Kev Nyab Xeeb Profile: As atsis yog -caloric sweetener, nws tsis nce ntshav qabzib lossis qib insulin, txhawb nqa nws cov khoom siv rau cov ntshav qab zib thiab tswj qhov hnyav. Nws cov metabolism tshwj xeeb txo qis phenylalanine tso tawm[2][3].
Kev Nyab Xeeb, Kev Tswj Xyuas Txheej Txheem & Kev Tshawb Fawb Kev Tshawb Fawb
Neotame tau pom zoo ua ibgeneral-lub hom phiaj sweetenerlos ntawm cov thawj coj tseem ceeb, suav nrog:
- US FDA (2002)
- JECFA(Joint FAO/WHO Expert Committee on Food Additives)
- Tuam Tshoj(GB 2760-2024)
- European Food Safety Authority (EFSA)
Neotame vs. Aspartame: Qhov tseem ceeb sib piv
| Feature | Neotame | Aspartame |
|---|---|---|
| Qab zib txheeb ze rau sucrose | 7, 000 - 13,000 zaug | ~ 200 lub sijhawm |
| Kev ruaj ntseg | Siab dua, tshwj xeeb tshaj yog nyob nruab nrab pH thiab kub | Tsawg dua, degrades hauv tshav kub / nruab nrab pH |
| Phenylalanine tso tawm | Tsawg kawg(Peptidase thaiv) | Qhov tseem ceeb (Full hydrolysis) |
| PKU Labeling yuav tsum tau | Tsis muaj | Yog lawm("Nrog Phenylalanine") |
| Caloric pab | Zoo li xoom (<0.3 kcal/g) | 4 kcal / g (tab sis siv me me) |
Ceeb Toom Txog Kev Tshawb Fawb Txog Kev Noj Qab Haus Huv
Thaum cov koom haum tswj hwm pom tias Neotame muaj kev nyab xeeb nyob rau hauv tsimTxais tau txhua hnub (ADIs), cov kev tshawb fawb tshawb fawb tsis ntev los no qhia txog thaj chaw rau kev tshawb nrhiav ntxiv.Hauv vitro(test-tube) cov kev tshawb fawb qhia tias nyob rau hauv siab concentrations, Neotame tej zaum yuavTej zaum yuav ua rau cov kab mob hauv plab hnyuv epithelial thiab cuam tshuam rau cov kab mob hauv plab, uas tuaj yeem txuas rau lub plab barrier dysfunction[4][5]. Lwm qhov kev tshawb fawb sau tseg tias nws yuavtxo qhov sib txawv ntawm plab microbiota. Cov kev tshawb fawb no qhia txog qhov tseem ceeb ntawm kev tshawb fawb tsis tu ncua tab sistsis txhob cuam tshuam cov kev ntsuas kev nyab xeeb tam sim norau cov tib neeg noj qib.
Kev Siv & Kev Siv Khoom Noj (raws li GB 2760-2024)
Neotame yog ntau yam. Cov lus hauv qab no qhia txog nws daim ntawv thov nyob rau hauv ntau hom zaub mov raws li Tuam Tshoj tus qauv hauv tebchaws:
| Qeb zaub mov | Cov khoom piv txwv | Kev siv ntau tshaj (g / kg) |
|---|---|---|
| Khoom noj khoom haus & lwm yam | Flavored fermented mis nyuj, Modulated mis nyuj hmoov | 0.065 - 0.1 |
| Frozen Desserts | Ice cream, Popsicles | 0.1 |
| Txiv hmab txiv ntoo | Jams, kaus poom txiv hmab txiv ntoo, txiv hmab txiv ntoo qhuav, Preserved txiv hmab txiv ntoo | 0.033 - 0.3 |
| Khoom noj khoom haus Bakery | Khoom qab zib, ncuav qab zib, ncuav qab zib, ncuav mog qab zib decorations | 0.08 |
| Khoom qab zib | Chewing gum, Lwm yam khoom qab zib | 0.33 - 1.0 |
| Dej haus | Txiv hmab txiv ntoo thiab zaub kua txiv haus | 0.033 |
| Condiments & Savory | Cov khoom qab zib qab zib, Compound seasonings, Vinegar | 0.012 - 0.07 |
| Lwm yam | Npaj- rau- noj zaub mov, cov khoom lag luam noodle | 0.06 - 0.16 |
Cov lus nug nquag nug (FAQ)
Q: Puas yog Neotame muaj kev nyab xeeb? Puas muaj tej yam tshwm sim?
A: Cov neeg saib xyuas kev noj qab haus huv thoob ntiaj teb thiab kev nyab xeeb khoom noj (US FDA, EFSA, JECFA) tau soj ntsuam thiab pom zoo Neotame kom muaj kev nyab xeeb rau tib neeg noj hauv ADI tsim. Qee cov neeg uas muaj kev nkag siab zoo rau cov khoom qab zib tuaj yeem ua rau lub plab zom mov me me yog tias noj ntau heev. Cov kev tshawb fawb soj ntsuam tsis ntev los no qhia tias muaj peev xwm cuam tshuam rau cov kab mob hauv plab thiab cov kab mob ntawm cov koob tshuaj ntau, ua pov thawj kev tshawb fawb ntxiv, tab sis cov kev tshawb pom no tsis sib npaug rau qhov ua pov thawj raug mob los ntawm kev noj zaub mov zoo.
Q: Cov neeg mob ntshav qab zib puas tuaj yeem siv cov khoom siv nrog Neotame?
A: Yog. Neotame tsis yog -caloric thiab tsis cuam tshuam rau cov ntshav qabzib lossis qib insulin, ua rau nws hloov cov piam thaj rau cov tib neeg uas tswj ntshav qab zib.
Q: Vim li cas thiaj xaiv Neotame tshaj Aspartame lossis Sucralose?
A: Neotame muaj kev sib xyaw ua ke ntawm cov khoom qab zib ntau dua (tus nqi qis dua - hauv- siv), cua sov thiab pH zoo dua li aspartame, thiab cov khoom qab zib huv dua li lwm cov khoom qab zib. Nws kuj zam qhov kev txhawj xeeb phenylalanine cuam tshuam nrog aspartame.
Q: Yuav khaws Neotame li cas?
A: Khaws rau hauv qhov chaw txias, qhuav hauv lub thawv kaw kom nruj kom tsis txhob nqus dej noo. Rau ntev - lub sij hawm cia (xyoo), -20℃yog pom zoo kom muaj kev ruaj ntseg zoo thiab purity.
Tiv tauj peb
Npaj txhij los tsim kho tshiab nrog ib qho ntawm cov qib siab tshaj plaws - siv cov khoom qab zib hauv khw? Peb siab -purityNeotame hmoov (CAS 165450-17-9)ua tau raws li cov zaub mov nruj thiab tshuaj- cov qauv qib.
Hu rau peb pab neeg muag khoom hnub no rau:
- Thov ibqauv dawbrau koj qhov kev sim R & D.
- Sib tham txog koj daim ntawv thov tshwj xeeb xav tau thiab tau txaiskev txhawb nqa.
- Tau txais cov ncauj lus kom ntxawsCertificate of Analysis (CoA)thiab tus nqi sib tw.
WhatsApp: +86-18066540910
E-mail:ella.zhang@huilinbio-tech.com.
Cov ntaub ntawv
- Reynolds, A., & Mitri, J. (2024, Plaub Hlis 28). Cov Lus Qhia Txog Kev Noj Qab Haus Huv Rau Cov Neeg Mob Ntshav Qab Zib. Table 1. TSIS MUAJ-NUB NYOOG SWEETERS. National Library of Medicine.
- Nofre, C., & Tinti, JM (2000). Neotame: kev tshawb pom, khoom, khoom siv.Khoom noj khoom haus Chemistry, 69(3), 245-257
- NCATS Inxight: Tshuaj. (nd).NEOTAME. US National Institutes of Health.
- Anglia Ruskin University (ARU). (Lub Plaub Hlis 24, 2024).Artificial sweetener muaj peev xwm ua rau lub plab puas[Xov xwm tso tawm]
- Li, Y., et al. (2025). Kinetics, kev koom tes, thiab txoj hauv kev ntawm degradation ntawm cov khoom qab zib los ntawm thawj thiab theem nrab radicals thaum UV / persulfate.Chemical Engineering Journal, 102345
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