Taw qhia
Sclareolide yog ib txwm tshwm sim sesquiterpene lactone muab los ntawm cov nroj tsuagSalvia sclrea(clary sage). Raws li bicyclic organic compound, nws tau txais kev saib xyuas tseem ceeb thoob plaws ntau qhov kev lag luam rau nws cov kev ua ub no ntau yam thiab kev nyab xeeb zoo heev.
Hauv kev lag luam tsw thiab tshuaj tsw qab, Sclareolide muaj nuj nqis rau nws cov yam ntxwv ntoo, ambergris-zoo li, thiab haus luam yeeb- toned aroma, nrog cov ntawv me me ntawm moss thiab cedar . Nws yog dav siv los ua tus neeg sawv cev flavoring (FEMA 3794) hauv cov khoom ci, dej haus, cov khoom noj siv mis, thiab cov ntawv siv savory, nrog rau cov tshuaj tsw qab hauv cov khoom qab zib zoo thiab cov khoom tu tus kheej.[3].
Tshaj li nws cov ntawv thov kev xav, kev tshawb fawb tshawb fawb tsis ntev los no tau nthuav tawm Sclareolide lub peev xwm tshuaj kho mob zoo kawg li. Cov kev tshawb fawb qhia tau hais tias nws cov kev ua tau zoo raws li tus neeg sawv cev antifungal tiv thaivCryptococcus neoformans, tus neeg sawv cev tiv thaiv kab mob tiv thaiv tus kab mob Ebola, ib qho tshuaj tiv thaiv -cov tshuaj tiv thaiv kab mob inhibiting nitric oxide ntau lawm, thiab cov tshuaj chemosensitizer txhawb nqa gemcitabine kev ua tau zoo hauv cov qog nqaij hlav pancreatic[1]. Qhov tseem ceeb tshaj plaws, kev sim tshuaj ntsuam xyuas xyoo 2025 tau lees paub tias cov tshuaj pleev thaiv hnub muaj Sclareolide thiab niacinamide ua rau muaj txiaj ntsig zoo tiv thaiv post-inflammatory hyperpigmentation (PIH) ntawm daim tawv nqaij ntawm cov xim, txhawb nws kev siv hauv cov tshuaj dermatological siab heev.[2].
Physical & Chemical Parameters
| Parameter | Specification / Tus nqi | Sau ntawv / Reference |
|---|---|---|
| Lub cev lub cev (20 degree) | Khoom | Crystalline hmoov |
| Xim | Dawb rau tawm -dawb | |
| Purity (GC) | Ntau dua lossis sib npaug li 98% | |
| Melting Point | 120-126 degree | Cov ntaub ntawv: 124-127 degree |
| Boiling Point | 341.9℃(kwv yees) | EPI Suite suav |
| Flash Point | >93°C (>200℃F) | Kaw khob |
| Log KOW (Octanol{0}}Dej) | 3.86 | EPI Suite suav |
| Dej Solubility | 11.99 mg / L (kwv yees) | EPI Suite suav |
| Vapor Siab | 0.0000159 mm Hg ntawm 20 degree | EPI Suite suav |
| Kev sib hloov kho qhov muag | +43.0℃rau +51.0℃(c=2, CHCl₃) | |
| UV Spectra | Tsis muaj absorbance 290-700 nm | Molar absorption coefficient<1000 L·mol⁻¹·cm⁻¹ |
| Solubility | Soluble hauv cov kuab tshuaj organic; insoluble hauv dej | |
| Kev cia khoom | -20℃nyob rau hauv nitrogen | Ntev - lub sij hawm cia |
| Txee lub neej | 1460 hnub (4 xyoos) | Raws li pom zoo cia |
Mechanism ntawm Action
Sclareolide siv nws cov teebmeem lom neeg sib txawv los ntawm ntau lub tshuab molecular, qhia txog nws lub peev xwm ua ntau yam -functional bioactive compound.
1. Antifungal Mechanism[1]
Tawm tsamCryptococcus neoformans, Sclareolide (MIC=16} µg/mL) ua los ntawm:
- Kev cuam tshuam ntawm membrane kev ncaj ncees:Propidium iodide tsub zuj zuj ntawm kev soj ntsuam qhia pom qhov txo qis hauv daim nyias nyias (6.62 ± 0.18% tom qab kho)
- Induction ntawm oxidative kev nyuaj siab:Qhov tseem ceeb nce cov pa oxygen hom (ROS) ntau lawm
- Mitochondrial tsis ua haujlwm:Txo cov mitochondrial membrane muaj peev xwm (MMP), qhia txog kev puas tsuaj mitochondrial
- Tsis yog -apoptotic cell tuag:Tsis ua rau caspase-dependent apoptosis
2. Anti-Inflammatory thiab Pigment-Txoj Cai Tswjfwm[2]
Hauv kev siv tshuaj dermatological, Sclareolide ua haujlwm los ntawm:
- Inhibition ntawm pro-inflammatory mediators:Txhawb nqa PGE₂ thiab IL-1 biosynthesis
- Nitric oxide txo:Inhibits TSIS MUAJ ntau lawm hauv LPS-stimulated BV-2 hlwb (IC₅₀=20.3 μM)
- Melanin inhibition:Modulates PIH-sociated gene qhia thiab txo melanin synthesis hauv melanocytes thiab tib neeg daim tawv nqaij ex vivo
- Antioxidant kev ua haujlwm:Txo txoj kev oxidative kev nyuaj siab uas txhawb kev ua haujlwm melanocyte
3. Kev tiv thaiv kab mob
Sclareolide ua raws li tus kab mob Ebola nkag mus inhibitor, txo cov kab mob HEK293T hlwb los ntawm tus kab mob HIV-raws li kab mob pseudotyped nrog Ebola tus kab mob glycoprotein (EC₅₀=8 μM).
4. Anticancer thiab Chemosensitizing teebmeem
Hauv gemcitabine-cov kab mob qog noj ntshav uas tiv thaiv kab mob pancreatic (PANC-1 thiab AsPC-1), Sclareolide (5-20 μM) txhim kho gemcitabine-induced cell tuag, qhia tias muaj peev xwm ua tus neeg sawv cev chemosensitizing.
5. Antifungal Activity Tawm tsam Phytopathogens
Sclareolide inhibits mycelial kev loj hlob ntawm ntau yam phytopathogenic fungi ntawm 100 ug / mL:Fusarium coeruleum (67.14%), Fusarium graminearum (46.22%), Curvularia lub cev (27.04%), Botrytis cinerea(33.93%), thiabAlternaria brassicae yog ib tsob nroj (32.48%) .
Cov txiaj ntsig tseem ceeb & qhov zoo
- Multi-Functional Bioactivity:Muab tshuaj tua kab mob, tshuaj tiv thaiv- mob, tshuaj tua kab mob, tshuaj tua kab mob, thiab xim xim- tswj cov dej num, ua rau nws muaj ntau yam kev tshawb fawb cov cuab yeej thiab cov khoom siv ua haujlwm[1][2].
- Clinically Validated Dermatological Efficacy:Ib 2025 randomized soj ntsuam kuaj pom tau hais tias ib tug tshuaj pleev thaiv hnub muaj Sclareolide ho tiv thaiv post- inflammatory hyperpigmentation, nrog tiv thaiv daim tawv nqaij qhia +5.96 ΔITA℃kev txhim kho piv rau -9.88 ΔITA℃nyob rau hauv daim tawv nqaij tsis tiv thaiv (net tiv thaiv ~ 16 ITA degree. 0 1 p <)[2].
- Zoo heev Safety Profile:RIFM kev ntsuam xyuas kev nyab xeeb lees paub tsis muaj kev txhawj xeeb rau genotoxicity; JECFA xaus lus "tsis muaj kev txhawj xeeb txog kev nyab xeeb ntawm cov theem tam sim no" raws li tus neeg sawv cev flavoring; tsis muaj toxicity pom nyob rau hauvGalleria melonellantawm 128 µg / ml[1][3].
- Superior Sensory Properties:Muab cov ntoo tshwj xeeb, ambergris-zoo li, thiab haus luam yeeb- toned aroma nrog moss thiab cedar nuances, khoom plig hauv cov tshuaj tsw qab zoo thiab cov tshuaj tsw qab.
- Regulatory Txais:Pom zoo raws li tus neeg sawv cev flavoring (FEMA 3794) nrog tsim siv theem thoob plaws ntau hom zaub mov; teev nyob rau hauv EU flavoring tshuaj (FL No. 16.055).
- High Purity & Stability:Muaj nyob rau ntawm ntau dua lossis sib npaug li 98% purity nrog cov txheej txheem stereochemistry (3aR configuration) thiab kev ruaj ntseg zoo nyob rau hauv kev pom zoo cia.
Cov ntawv thov tseem ceeb
| Kev lag luam / Sector | Piv txwv daim ntawv thov | Lub luag haujlwm ua haujlwm & Cov txiaj ntsig |
|---|---|---|
| Kev tu tawv nqaij & Tshuaj pleev ib ce | Anti-cov tshuaj tiv thaiv kev laus, cov tshuaj pleev kom pom kev zoo, tshuaj pleev thaiv hnub, tom qab- txheej txheem txheej txheem | Tiv thaiv post-inflammatory hyperpigmentation; txo o thiab oxidative kev nyuaj siab; inhibits melanin synthesis[2] |
| Kev lag luam tsw | Cov khoom ci, khoom noj siv mis, dej haus, savory flavors, confectionery | Imparts woody, ambergris, thiab ntawv luam yeeb; FEMA 3794 pom zoo nyob rau hauv cov theem ib txwm (1-3 mg / kg) |
| Kev lag luam tshuaj tsw qab | Cov tshuaj tsw qab zoo, cov khoom tu tus kheej, cov tshuaj tsw qab hauv tsev | Muab cov ntoo tshwj xeeb-mossy puag sau ntawv nrog kev ua siab ntev zoo[3] |
| Pharmaceutical Research | Kev txhim kho tshuaj tiv thaiv kab mob; Kev tshawb nrhiav tshuaj tiv thaiv kab mob; kev tshawb nrhiav mob qog noj ntshav | Tus neeg saib xyuas rau cryptococcosis; Ebola tus kab mob nkag mus inhibitor; chemosensitizer rau mob qog noj ntshav pancreatic[1] |
| Kev tshawb fawb txog kev ua liaj ua teb | Kev tshawb fawb txog kev tiv thaiv qoob loo; antifungal tus neeg sawv cev txhim kho | Inhibits phytopathogenic fungi cuam tshuam rau cov qoob loo |
| Anti- Kev Tshawb Fawb Txog Kab Mob | Cov qauv ua paug; cytokine kev tswj xyuas | Inhibits TSIS MUAJ ntau lawm thiab pro-inflammatory mediator synthesis[2] |
Hom Kev Siv Qib (Kev lag luam Flavor):
- Cov khoom ci: 2.0-3.0 mg / kg
- Cov mis nyuj khov: 1.0-3.0 mg / kg
- Cov khoom qab zib mos: 1.0-3.0 mg / kg
- Cov dej qab zib: 1.0-5.0 mg / kg
- Cov khoom noj nqaij: 1.0-4.0 mg / kg
- Khoom noj txom ncauj: 2.0-4.0 mg / kg
Formulation & Handling Reference
Solubility Qhia:Sclareolide yog insoluble hauv dej tab sis soluble hauv cov kuab tshuaj organic xws li ethanol, DMSO, thiab chloroform. Rau cov qauv tshuaj pleev ib ce, ua ntej- dissolve nyob rau hauv cov roj theem lossis hauv cov kuab tshuaj sib xyaw ua ntej koom ua ke[3].
Kev Tshawb Fawb Txog Kev Tshawb Fawb:
Kev tshawb fawb tshuaj tua kab mob: 16-128 µg/mL (MIC: 16 µg/mL tiv thaivC. neoformans) [1]
Anti- kev tshawb fawb inflammatory: 5-20 µM (IC₅₀ rau NO inhibition: 20.3 μM)
Kev tshawb fawb tshuaj tiv thaiv kab mob: EC₅₀=8 μM tiv thaiv Ebola pseudovirus
Kev siv tshuaj kho mob: Raws li tsim nyob rau hauv cov khoom siv tshuaj pleev thaiv hnub (0.1-1% ntau yam)[2]
Kev ruaj ntseg ntawm kev daws teeb meem:Npaj cov kev daws teeb meem tshiab thaum twg los tau. Rau cov kev daws teeb meem hauv DMSO lossis ethanol, aliquot thiab khaws cia ntawm -20℃tiv thaiv los ntawm lub teeb. Tsis txhob rov qab khov-thaw cycles.
Kev Tiv Thaiv Kev Tiv Thaiv:Siv qhov cua kom txaus. Hnav cov khoom tiv thaiv tus kheej tsim nyog ( hnab looj tes, tsom iav kev nyab xeeb). Tsis raug cais raws li cov khoom siv phom sij rau kev thauj mus los. Xa mus rau Daim Ntawv Qhia Kev Nyab Xeeb (SDS) kom ua tiav kev tuav thiab cov ntaub ntawv xwm txheej ceev.
Formulation Compatibility:Tau tshaj cov khoom xyaw tshuaj pleev ib ce xws li niacinamide (pom zoo hauv kev tshawb fawb soj ntsuam), emollients, emulsifiers, thiab tshuaj pleev thaiv hnub[2].
FAQ: Cov lus nug nquag nug
Q: Dab tsi yog qhov tsw profile ntawm Sclareolide?
A: Sclareolide muaj cov yam ntxwv ntoo, ambergris-zoo li, thiab haus luam yeeb- toned aroma nrog cov ntawv me me ntawm moss, cedar, thiab musk. Ntawm 1% concentration, nws pom muaj zog aromatic woody thiab mossy yam ntxwv.
Q: Puas yog Sclareolide muaj kev nyab xeeb rau kev siv tawv nqaij?
A: Yog. Ib xyoo 2025 kev soj ntsuam kuaj pom pom tau zoo heev uas tsis muaj cov xwm txheej tsis zoo tshwm sim hauv cov neeg koom siv tshuaj pleev thaiv hnub muaj Sclareolide[2]. RIFM kev ntsuam xyuas kev nyab xeeb lees paub nws txoj kev nyab xeeb rau kev siv tshuaj pleev ib ce thiab tshuaj tsw qab[3].
Q: Qhov txawv ntawm Sclareolide thiab Sclareol yog dab tsi?
A: Sclareolide yog lactone derivative ntawm Sclareol, tsim los ntawm oxidation. Thaum ob qho tib si yog diterpenes los ntawm clary sage, Sclareolide nthuav tawm txhim kho kev ruaj ntseg thiab kev ua haujlwm lom neeg sib txawv, suav nrog ntau lub zog los tiv thaiv - mob thiab tshuaj tua kab mob.
Q: Yuav ua li cas Sclareolide hmoov yuav khaws cia ntev -lub sij hawm ruaj khov?
A: Rau qhov siab tshaj plaws txee lub neej (txog 4 xyoos), khaws cov hmoov Sclareolide ntawm -20℃nyob rau hauv nitrogen cua, tiv thaiv los ntawm lub teeb thiab noo noo. Khaws lub ntim kom nruj thaum tsis siv.
Q: Puas yog Sclareolide puas muaj kev cuam tshuam txog tshuaj noj?
A: Sclareolide tau pom tias txhim kho gemcitabine-induced cell tuag nyob rau hauv pancreatic cancer hlwb, qhia txog tej yam chemosensitizing cov teebmeem. Txawm li cas los xij, tsis muaj qhov tseem ceeb CYP450 kev sib cuam tshuam tau raug tshaj tawm; ADMET kev kwv yees qhia tias nws tsis yog -inhibitor ntawm CYP enzymes loj.
Q: Puas yog Sclareolide tshwm sim?
A: Yog lawm, Sclareolide yog ib yam phytochemical pom nyob rau hauv clary sage (Salvia sclarea) thiab tseem muaj nyob rau hauv luam yeeb. Cov khoom lag luam muaj nyob hauv cov khoom lag luam yog xwm - zoo tib yam thiab tuaj yeem muab tau los ntawm cov khoom siv ntuj tsim lossis tsim khoom siv hluavtaws .
Q: Dab tsi yog qhov tseem ceeb ntawm kev pom zoo rau Sclareolide?
A: Sclareolide tau txais kev pom zoo ua tus neeg sawv cev flavoring nrog FEMA tus lej 3794. Nws tau teev nyob rau hauv EU Flavorings Database (FL No. 16.055) thiab tau raug soj ntsuam los ntawm JECFA, uas tau xaus "tsis muaj kev txhawj xeeb txog kev nyab xeeb ntawm cov theem tam sim no." RIFM tau ua tiav qhov kev ntsuam xyuas kev nyab xeeb ntawm cov tshuaj tsw qab[3].
Q: Sclareolide puas tuaj yeem siv rau hauv "natural" cov khoom lag luam?
A: Kev cai txhais lus txawv raws cheeb tsam. Sclareolide muab tau los ntawm tej yam ntuj tso (xws li, clary sage extraction) tej zaum yuav tsim nyog rau natural labeling nyob rau hauv ib co jurisdictions. Thov sab laj nrog cov kws tshaj lij kev tswj hwm rau koj lub hom phiaj kev lag luam.
Ua tam sim no
Txhim kho koj cov tawv nqaij, tsw, lossis kev tshawb fawb tshuaj nrog pebsiab -purity Sclareolide hmoov. Rov qab los ntawm kev tswj xyuas kom zoo, cov ntaub ntawv txheeb xyuas dav dav, thiab lub cev loj hlob ntawm cov pov thawj tshawb fawb txhawb nqa nws cov bioactivities ntau haiv neeg, nws yog qhov kev ntseeg siab rau cov neeg tsim khoom thoob ntiaj teb.
Hu rau peb pab neeg muag khoom hnub no rau:
- Thov ib qho qauv rau koj qhov kev tsim kho thiab kev ntsuam xyuas.
- Tau txais cov lus sib tw rau R&D, pilot- ntsuas qhov ntsuas, lossis kev xav tau ntau lawm.
- Tau txais cov ntaub ntawv nthuav dav, suav nrog Daim Ntawv Pov Thawj Kev Ntsuam Xyuas (CoA) thiab Daim Ntawv Qhia Txog Kev Nyab Xeeb (SDS).
Thov hu rau peb ntawmella.zhang@huilinbio-tech.com.
Cov ntaub ntawv
- Ganeshkumar, A., Lima, PMN d., Haribabu, J., et al. (2024). Sclareolide li Antifungal Strategy Tawm tsam Cryptococcus neoformans: nthuav tawm nws cov txheej txheem ntawm Kev Ua.Cov kab mob, 12(11), 2324.
- Passeron, T., Piquero-Casals, J., Brown, A., et al. (2025). Tus kws tshawb nrhiav-Qhov muag tsis pom kev, Randomized sim ntawm qhov dav -Spectrum Sunscreen muaj Sclareolide thiab Niacinamide rau Kev Tiv Thaiv Kev Tshaj Tawm - mob hyperpigmentation hauv daim tawv nqaij xim.Dermatology thiab Kev Kho Mob.
- Lub koom haum tshawb fawb rau cov khoom siv tshuaj tsw qab (RIFM). (2022). RIFM tshuaj tsw qab tshuaj ntsuam xyuas kev nyab xeeb, sclareolide, CAS Registry Number 564-20-5.Khoom noj khoom haus thiab tshuaj toxicology.
Tsis lees paub:Cov ntaub ntawv ntawm cov khoom no yog npaj rau kev lag luam -rau- kev lag luam (B2B) siv los ntawm cov kws tshaj lij hauv kev lag luam tshuaj pleev ib ce, tsw, thiab kev tshawb fawb. Cov nqe lus uas muaj nyob hauv no yog ua raws li cov ntaub ntawv tshawb fawb tam sim no thiab cov ntaub ntawv xa khoom thiab muab rau cov ntaub ntawv xov xwm nkaus xwb. Cov khoom no yog siv rau kev tshawb fawb thiab kev tsim khoom nkaus xwb. Tsis yog rau cov neeg siv khoom siv ncaj qha. Nws yog tib lub luag haujlwm ntawm cov chaw tsim khoom tiav los xyuas kom meej tias ua raws li tag nrho cov kev cai hauv zos, teb chaws, thiab thoob ntiaj teb. Cov lus qhia tshwj xeeb tuaj yeem hloov pauv yam tsis tau ceeb toom; ib txwm thov daim ntawv pov thawj tseeb ntawm Kev Ntsuam Xyuas ua ntej xaj xaj.
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