Palmitoyl Tripeptide -8

Khoom Taw Qhia

Palmitoyl tripeptide -8yog ib tug hluavtaws peptide. Tripeptide -8 reacts nrog palmitic acid los tsim palmitoyl tripeptide. Xws li arginine, histidine thiab phenylalanine. Nws muaj kev ua haujlwm ntawm multifunctional neuropeptide. Thaum ua ke nrog cov txiaj ntsig fatty acids xws li palmitic acid, nws muaj txiaj ntsig zoo rau daim tawv nqaij. Palmitoyl tripeptide -8 yog ib qho me me molecular tripeptide uas muaj cov haujlwm tshwj xeeb los tiv thaiv kab mob. Cov peptides tuaj yeem nkag mus rau hauv lub epidermis thiab ncaj qha mus txog lub dermis, thiab ua lub luag haujlwm hauv kev tswj cov tawv nqaij protein. Raws li lub hauv paus ntsiab lus ntawm kev ua xua ntawm daim tawv nqaij thiab ua txhaum los ntawm cov kev txwv ntawm cov khoom xyaw ib txwm muaj, bionic tripeptide tsim kev tshawb fawb tuaj yeem hloov cov tawv nqaij neuropeptides (qee qhov endogenous neuropeptides muaj cov tshuaj tiv thaiv ntuj tsim) los daws cov teeb meem ntawm cov tawv nqaij ua xua.

Cov ntaub ntawv yooj yim

Kev ua tau zoo ntawm palmitoyl tripeptide -8

1. Palmitoyl tripeptide -8tuaj yeem txhawb cov synthesis ntawm collagen (hom ⅰ, hom ⅱ thiab hom ⅳ) thiab tsim cov proteins ntawm extracellular matrix los ntawm kev ua haujlwm ntawm cov hlwb stromal, txhim kho lub ntsej muag elasticity thiab txo lub ntsej muag wrinkles.
2. Nyob rau tib lub sijhawm, nws kuj muaj cov yam ntxwv ntawm kev ua kom lub cev muaj zog, ua kom cov tawv nqaij noo noo, txhim kho cov tawv nqaij ci thiab txhim kho cov xim ntawm daim tawv nqaij.
3. Tiv thaiv thiab txhim kho cov hlab ntsha o thiab khaus, xws li erythema, ntshav liab, o, tingling thiab khaus;
4. Txo cov tawv nqaij khaus tshwm sim los ntawm ultraviolet rays, tiv thaiv kev tiv thaiv, sab hauv siab thiab mechanical siab;
5. Tuav thiab rov ua dua qhov qub rhiab heev ntawm daim tawv nqaij, thiab kho thiab txo cov hlwb puas.

Lub hauv paus ntsiab lus ntawm palmitoyl tripeptide -8

Kev ua haujlwm lom neeg hauv keratinocytes, palmitoyl tripeptide -8 tuaj yeem txo qhov tso tawm ntawm cytokine IL-8 tshwm sim los ntawm ultraviolet B(UVB) irradiation los ntawm kev sib txuas nrog MC1-R.
Hauv keratinocytes, palmitoyl tripeptide -8 tuaj yeem cuam tshuam kev tsim tawm ntawm IL-8 ntxias los ntawm IL-1A, uas qhia tau tias palmitoyl tripeptide -8 tuaj yeem cuam tshuam rau theem pib ntawm cov tshuaj tiv thaiv cascade. .
Txo vasodilation thiab permeability, txo edema thiab erythema.
Tsis tas li ntawd, palmitoyl tripeptide -8 tuaj yeem txo cov txiaj ntsig tsis zoo tshwm sim los ntawm kev tso tawm cov tshuaj P.

Synthesis ntawm palmitoyl tripeptide -8

Tsoos peptide synthesis chemistry method thiab kua-theem peptide synthesis method. Vim tias nws cov ntu luv luv, cov amino acids loj thiab cov nqi siab hauv cov khoom sib txuas hauv lub xeev, nws nyuaj rau kev npaj ntau ntau.

Ua kua-theem synthesis muaj qhov zoo ntawm kev noj cov amino acid tsawg dua thiab muaj txiaj ntsig siab, thiab tuaj yeem npaj tau ntau heev. Txawm li cas los xij, cov txheej txheem ua kua-theem synthesis uas twb muaj lawm yog qhov nyuaj, siv ntau cov kuab tshuaj organic, thiab muaj tus nqi siab thiab tsis zoo ib puag ncig.

Palmitoyl tripeptide -8 thiab nws cov yam ntxwv

Palmitoyl tripeptide -8yog ib qho kev sib koom ua ke hauv kev lag luam tshuaj pleev ib ce, uas tuaj yeem siv los txhim kho permeability thiab ruaj khov ntawm cov khoom xyaw nquag ntawm daim tawv nqaij. Nws cov qauv muaj palmitic acid thiab tripeptide -8 (tseem hu ua Pasteurella-Duchenne pentapeptide). Ntawm lawv, palmitic acid tsim ib tug kheej kheej los yog tabular multilayer qauv los ntawm kev sib txuas nrog phospholipids, thiab muaj biocompatibility zoo. Thiab tripeptide -8 yog collagen analogue, uas ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev laus,
Nws ua lub luag haujlwm tseem ceeb hauv kev txhawb nqa cov tawv nqaij rov tsim dua tshiab.

Cov lus qhia rau kev siv

Cov rog-soluble active polypeptide yog ib qho yooj yim rau absorbed los ntawm daim tawv nqaij, muaj permeability zoo, bioavailability siab thiab zoo stability;
Tshwj xeeb tshaj yog tsim nyog rau txhua hnub soothing thiab kho cov tawv nqaij rhiab, kev saib xyuas tom qab hnub ci thiab kev tiv thaiv tawv nqaij txhua hnub;
Nws muaj txiaj ntsig zoo rau cov teeb meem ntawm daim tawv nqaij xws li erythema, ntshav liab, o, tingling thiab khaus.
Qhov ntau npaum li cas hauv keeb kwm yog {{0}}.5%, qhov pom zoo noj yog 0.05% ~ 0.3%, thiab nws tau ntxiv rau tom qab theem ntawm kev tsim khoom thaum kub qis dua tshaj 40 degree.

Hauv vitro xeem ntawm palmitoyl tripeptide -8

Hauv cov qauv hauv vitro, palmitoyl tripeptide {{0}}} pom txog 32% tseem ceeb inhibitory nyhuv ntawm IL-8 ntau lawm hauv keratinocytes irradiated los ntawm UVB, uas yog sib npaug rau -MSH, thiab kuj tshwm sim. mus rau 64% inhibitory nyhuv nyob rau hauv fibroblasts stimulated los ntawm IL-1, uas yog ntau tshaj qhov ua tiav los ntawm -MSH. Nyob rau hauv daim tawv nqaij explants raug tshuaj P, palmitoyl tripeptide -8 txo tus naj npawb ntawm dilated capillaries thiab qhov loj ntawm cov hlab ntsha dilated, mus txog 30% thiab 51% feem. Vim palmitoyl tripeptide -8, edema kuj raug txo los ntawm 60%. Tom qab lub sijhawm no, ib thaj chaw uas muaj 250 l ntawm 0.5% sodium dodecyl sulfate (SDS) aqueous tov tau thov rau 24 teev tom qab lub thaj raug tshem tawm thiab lub sijhawm so ntawm 24 teev. Tom qab ntawd, qhov chaw kuaj tau thaij duab nrog lub tshuab tsom iav video, thiab nws qhov ntsuas kub tau ntsuas nrog Thermovision (lub ntsuas kub ntsuas los ntawm lub koob yees duab infrared). Tus neeg muag khoom tau tshaj tawm tias thaum palmitoyl tripeptide -8 tau siv rau ntawm daim tawv nqaij, cov duab pom cov xim liab txo qis, txawm tias tsis muaj kev ntsuas ntau. Hauv thaj chaw uas tau siv palmitoyl tripeptide -8, nws tau pom tias qhov kub ntawm daim tawv nqaij tshwm sim los ntawm SDS nce thiab txo qis. Tsis muaj qhov sib txawv tseem ceeb hauv kev tswj cov txiaj ntsig. Hauv lwm txoj kev tshawb fawb, suav nrog 13 tus neeg mob uas tsis tau qhia txog qhov mob ntawm daim tawv nqaij, tib thaj chaw uas muaj 250 μ l ntawm 0.5% sodium dodecyl sulfate tov tau siv nyob rau ntau qhov chaw ntawm lub xib teg ntawm caj npab rau 24 teev. Thib peb, thaij duab ntawm qhov chaw sim thiab ntsuas nws qhov kub thiab txias nrog cov khoom siv tib yam. Thaum tsis muaj kev ntsuas ntau, cov tawv nqaij liab nyob rau hauv qhov chaw uas siv cov mis ntsuas tau txo qis, thiab cov tawv nqaij kub nce los ntawm SDS poob los ntawm 78% ntawm qhov nruab nrab, uas yog qhov tseem ceeb, tsis zoo rau kev tswj xyuas. Hauv ib lo lus, cov txiaj ntsig no qhia tau hais tias palmitoyl tripeptide -8 tuaj yeem tiv thaiv thiab txo qhov kev xav tau.

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• Peb cov txheej txheem tsim khoom muaj txiaj ntsig zoo thiab ua kom cov txiaj ntsig zoo ib yam.
• Peb txhim kho kev sib tw ntawm lub tuam txhab los ntawm kev siv cov kev tswj xyuas zoo, kom paub txog qhov zoo thiab tus nqi qispalmitoyl tripeptide -8.
• Peb cov khoom xyaw ntuj tsim los ua kom tau raws li qhov xav tau ntawm cov neeg siv khoom niaj hnub no.
• Peb tau xaiv lub tuam txhab uas ua raws li txoj cai zoo raws li peb cov khoom siv raw khoom.
• Peb muab ntau yam kev xaiv ntim rau cov khoom xyaw ntuj.
• Peb tau nkag mus rau theem tshiab los ntawm hom kev tsim khoom ib txwm muaj, uas ua rau muaj kev muaj tswv yim thiab qib ua hauv cov txheej txheem tsim khoom, uas yog kev ua haujlwm thev naus laus zis.
• Peb muaj cov ntaub ntawv pov thawj zoo ntawm kev muab cov khoom zoo zoo rau peb cov neeg siv khoom.
• Txhua tus neeg ua haujlwm ntawm lub tuam txhab tau mob siab rau lub koob meej ntawm lub npe nrog kev ntseeg siab, kev mob siab rau, kev ua siab ntev thiab kev paub txog lub luag haujlwm!
• Peb tuaj yeem tau txais txiaj ntsig zoo thiab nce cov txiaj ntsig los ntawm kev txhim kho cov txheej txheem thiab hloov kho qhov kawg ntawm palmitoyl tripeptide -8.

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