Muaj cov khoom siv Epimedium rau 200+} homewetical thiab kev kho kom zoo nkauj, Kuv nquag tau nug:"Kuv puas yuav siv ICARIIN Ceg cais lossis puv-spectrum glycosides?"Cia peb txiav tawm lawv qhov sib txawv tseem ceeb nrog cov qauv kev pom zoo.
Cov tub ntxhais sib txawv: cais tawm vs. complex
🔬 ICariin Hmoov Extract(Ntshiab sib xyaw)
Zaj piav: Yam tsawg kawg 90% lim dlified iCari (C33H40o15) ¹
Lub hauv paus: Feem ntau los ntawmEpimedium Brevicornumnplooj
Qhov tseem ceeb nkauj: Tshuaj pleev xim rau cov tshuaj ntsiav tshuaj
🌿 Epimedium glycoside hmoov extract(Tag nrho flavonoids)
Zaj piav: Qauv 10-40% tag nrho iCari-hom flavonoids²
Muaj pes tsawg: Icariin (30-50%) +}}}}}}} {4 4}}% ³
Qhov tseem ceeb nkauj: Entourage cuam tshuam rau ntau cov txiaj ntsig
Lub taub hau-rau-lub taub hau sib piv: Science sib ntsib daim ntawv thov
| Chaw ua uas tsis tau haus | ICariin Hmoov | Epimedium glycosides | Muaj Qhov cuam tshuam |
|---|---|---|---|
| Bioavailability | 12% qhov ncauj nqus | 38% (cov cab kuj-kev thauj khoom) ⁶ | Glycosides zoo dua rau cov tshuaj |
| Thermal ruaj khov | Degrades >60 degree ⁷ | Ruaj khov rau 80 degree ⁸ | Glycosides haum cov tshuaj pleev xim rau cov tshuaj pleev |
| So | Insoluble hauv dej (<0.1mg/ml)⁹ | Dej-dispersible (ntau dua los yog sib npaug rau 5mg \/ ml) ¹⁰ | Glycosides rau cov tshuaj haus |
| Tus Nqi Muaj Zog | $ 2200 \/ kg (98% purity) | $ 480 \/ kg (30% tag nrho flavonoids) | Glycosides ↓ Tsim Tsiaj 56% |
Synergistic cuam tshuam: qhov chaw uas lawv tau txais txiaj ntsig
💊 Nutraceutical Daim Ntawv Thov
ICariin ntug:
↑ Nitric Oxide ntau lawm los ntawm 83% (vasyodilation) ¹¹
FDA Tshuaj Ntsuam Cov Tshuaj Tshiab Rau Txoj Cai Osteoporosis
Glycosides 'kom zoo dua:
ICariside II ↓ Cov Pob Txheem Ua Si 2.1X vs. ICARIIN NIST¹³
Epimedin C Enhances Icariin Kev nqus tau los ntawm 67% ¹⁴
Cov Lus Qhia Tsim: Muab 10% Icariin {+ 90}% glycosides rau kev ua kom zoo tshaj plaws rau cov kabmob pob txha.
💄 Kev ua kom zoo nkauj
ICariin nyob rau hauv surums:
{{0 {0}}. 5%}. 5% ↑ collagen Kuv synthesis los ntawm 49% ¹⁵
Glycosides hauv cream:
Epimedin B ↑ Hyaluronic Acide Production 3.2x VS Met¹⁶¹⁶
| Kev Tiv Thaiv Kev Laus Me Nyuam | ICariin 0. 5% | Glycoside muab 2% |
|---|---|---|
| Wrinkle qhov tob ↓ | 28% ntawm 8 lub lis piam | 41% ntawm 8 lub lis piam |
| Daim tawv nqaij elastic ↑ | +19% | +32%¹⁸ |
| Noo noo khaws | +22% | +38%¹⁹ |
Kev tswj cov lus qhia tsis ua haujlwm
| Cheeb tsam | ICariin Txoj Cai | Epimedium Glycosides xwm txheej |
|---|---|---|
| Usa | NDIN required >95% purity²⁴ | Daim Ntawv Ceeb Toom No. GRN 001022 |
| EU | Daim Ntawv Thov Khoom Noj Khoom Noj Khoom Haus Tseem Ceeb | Tsoos tshuaj ntsuab raws li daim ntawv sau npe (TMPD) |
| Phiaj suav | Pharmacopoeia monograph (ICP2020) | Pom zoo cov zaub mov noj qab haus huv |
Koj Daim Qauv FORDBook
🧪 Rau Cov Khoom Noj Noj Qab Haus Huv
- Qhov Kev Xaiv Zoo: Epimedium Glycosides 30% + Vitamin K2 (200MCG)
- Dosing: 250mg \/ hnub txheem rau 15% iCariin
- Secmical thaub qab: ↑ Cov pob txha pob zeb ceev ntom 7.3% vs placebo²⁵
💧 Rau kev tiv thaiv kev laus laus
- Qhov Kev Xaiv Zoo: {0. 8% Icariin (Nanoliposome encapsulated)
- Tsev noj mov: 2% syn®-coll + 1}} Ceramide np
- Ua yeeb yam: ↓ mmp -1 Tshaj tawm 62% ntawm 4 asthiv
Ntawv Sawv cev
- ICariin txhais: Suav Pharpercopoia 2020, Vol iv. 328
- Glycoside qauv: EMA Kev Ntsuas Kev Ntsuam Xyuas EMA \/ HMPC \/ 680259\/2013
- Kev Ntsuam Xyuas: Zhang li al., J Chromatogram B. 2018; 1092: 506-513
- Cov nyhuv entourage: Li li al., Phytomedicine. 2021; 93: 153798
- Bioavailability: Liu et al., Kev muab tshuaj metab. 2005; 33 (11): {1675-1683
- Cov nroj tsuag thauj: Chen li al., EUR J tshuaj lom. 2018; 122: 42-54
- Thermal degradation: Wang li al., Khoom Noj Khoom Noj. 2016; 212: 110-117
- Cov ntaub ntawv ruaj khov: GMP daim ntawv pov thawj c {0}} q -23-178 (2023)
- Solubility Profile: Pubchem cid 5318997
- Dej dispersibility: Tech Dossier Epi-Glyc-wd -09
- Tsis muaj ntau lawm: XU li al., Lub neej Sci. 2007; 80 (23): 2132-2138
- FDA Ind: ClinicalSt.Gov NCT05688941
- Icariside Synergy: Wong li al., J orthop res. 2009; 27 (9): 1182-1187
- Ua kom haum: Nws li al., Yeeb tshuaj Dev Indaptor. 2016; 42 (9): {1359-1365
- Collagen synthesis: Lin li al., Int J Mol Sci. 2019; 20 (21): 5273
- Hyaluronic Acid: Kho kom zoo nkauj tshuaj ntsuam xyuas cir -0824 f (2022)
- Tsev kho mob kawm: J Cosmet Dermatol. 2023; 22 (khoom 1): 15-22
- Elasticity ntsuam xyuas: Cutis. 2024; 113 (2): e 12- e18
- Yoov cov ntaub ntawv: Daim tawv nqaij resn technol. 2022; 28 (4): 595-601
- HPLC Txuj Ci: USP-NF<2028>Botanical cia
- UV Spectrum: European pharmacopoia 11. {0, 01\/2023: 2485
- Melting taw tes: Sigma-aldrich daim ntawv pov thawj ntawm kev tsom xam BCT9752
- Piv txwv tau: Leej twg monographs vol. 5, 2021 Annex 3
- FDA NDIN: GRN 001085 (tseem yog)
- Pob Txha Ntsis Kev Kawm: Osteoporos int. 2020; 31: 2319-2331
- * MMP -1}}}} ໂນ} exp wb dermatol. 2021; 30 (9): {1293-1301