Kev siv idebenone hmoov hauv tshuaj yog dab tsi?

Cov ntaub ntawv tseem ceeb ntawm Idebenone

Lub npe tshuaj ntawmidebenone hmoovyog 6-(10-hydroxydecyl)-2, 3-dimethoxy-5-methylbenzoquinone, uas yog cov tshuaj txiv kab ntxwv daj lossis txiv kab ntxwv crystalline. Cov khoom yog insoluble hauv dej, soluble hauv methanol, ethanol, thiab lwm yam kuab tshuaj, tsis muaj ntxhiab tsw, thiab nws cov khoom yog ruaj khov heev.

Idebenone tau tsim thiab ua lag luam hauv xyoo 1986, uas tuaj yeem txhim kho lub hlwb ua haujlwm tsis zoo, txhim kho kev siv cov piam thaj hauv lub hlwb, thiab txhawb kev tsim ntawm ATP; Nyob rau tib lub sijhawm, nws kuj muaj zog antioxidant zog, uas yog qhov zoo hauv kev tshem tawm cov dawb radicals. Clinically, cov khoom no tsuas yog siv rau lub paj hlwb, xws li tus kab mob Parkinson, thiab lwm yam. Los ntawm kev ua tau zoo ntawm cov tshuaj no, cov khoom no tuaj yeem siv tau zoo hauv cov khoom siv kho mob thiab tshuaj, thiab yog cov khoom siv raw zoo hauv cov khoom no. teb.

Txoj kev npaj ntawm idebenone

1. Muab 3-4-5-trimethoxytoluene, 10-acetoxydecanoyl chloride, thiab txhuas trichloride hauv dichloroethane, txias nrog dej khov, thiab do kom hnov ​​​​mob.

2. Muab tso rau hauv dej khov, rho tawm dichloromethane, thiab tom qab ntawd tau txais 6-(10-acetoxy-1-oxodecyl)-2,3-dimethoxy-5-methyl phenol raws li lub teeb xim av roj.

3. Ntxiv methanol thiab sodium hydroxide mus do, tom qab ntawd evaporate cov kuab tshuaj, ntxiv dej, thaum kawg lim, cais tawm cov muaju, thiab lub tshuab nqus tsev qhuav kom tau cov khoom nyoos.

4. Dissolve cov khoom crude nyob rau hauv chloroform, cais nws nrog ib tug silica gel kem, ces elute, sau cov khoom uas yuav tsum tau, evaporate cov kuab tshuaj, thiab ces recrystallize kom tau ib tug dawb crystalline 6-(10-hydroxy{ {3}} oxodecyl)-2, 3-dimethoxy-5-methyl phenol.

5. Sib tov nrog acetic acid, Pd-C, thiab perchloric acid, thiab hydrogenated nyob rau hauv chav tsev kub thiab siab los nqa tawm cov tshuaj tiv thaiv. Tom qab ntawd cov catalyst tau lim tawm, concentrated, thiab tom qab ntawd dichloromethane tau ntxiv los ua cov kauj ruam xws li ntxuav, ziab, thiab distilling tawm cov kuab tshuaj kom tau txais 6-(10-hydroxydecyl)-2, 3-dimethoxy-5-methyl li lub teeb xim roj phenol.

6. Sib tov cov roj nrog freshly npaj Fremite ntsev, dimethylformamide dej-methanol, thiab potassium dihydrogen phosphate, thiab lwm yam, do, thiab tom qab cov tshuaj tiv thaiv tiav, ntxiv dej rau dilute, thiab ces muab rho tawm nrog dichloromethane. , thiab tom qab ntawd los ntawm cov kauj ruam ntawm kev ntxuav, ziab, recrystallization, thiab lwm yam, idebenone thaum kawg tau txais.

Kev siv Idebenone

1. Nws tuaj yeem tiv thaiv senile dementia, thiab txhim kho lub hlwb ua haujlwm, metabolism, thiab cov tsos mob ntawm lub hlwb.

2. Nws muaj txiaj ntsig zoo ntawm kev txo cov ntshav siab.

3. Muaj peev xwm inhibit qhov tsim ntawm lipid peroxides hauv hlwb mitochondria.

4. Idebenone hmoovmuaj zog antioxidant nyhuv.

5. Nws muaj txiaj ntsig zoo rau kev txhim kho lub hlwb lub zog metabolism.

6. Nws tuaj yeem txhim kho kev siv cov piam thaj hauv lub hlwb thiab ua kom cov ATP ntau lawm.

7. Nws tuaj yeem txhim kho lub hlwb ua haujlwm tsis zoo, tsis nco qab, kev xav tsis zoo, kev txwv kev hais lus, dementia, thiab lwm yam kab mob tshwm sim los ntawm cerebral hemorrhage.

Daim ntawv thov kho mob

1. Nws tuaj yeem siv rau ntau yam kab mob paj hlwb, thiab muaj txiaj ntsig zoo rau Parkinson's, Alzheimer's kab mob, thiab lwm yam kab mob.

2. Nws tuaj yeem siv rau kev kho mob ntawm ntau yam kab mob, xws li kev hais lus tsis zoo.

3. Rau kev kho mob ntawm cov hlab plawv thiab cerebrovascular kab mob.

Idebenone kev phiv

Lus Cim: Qhov tshwm sim ntawm cov kev mob tshwm sim rau cov khoom no yog 3.77 feem pua.

1. Kev ua xua: Qee zaus, pob khaus thiab lwm yam tshwm sim ntawm daim tawv nqaij yuav tshwm sim.

2. Hais txog lub plab zom mov: xeev siab, tsis qab los noj mov, raws plab, thiab lwm yam teeb meem tshwm sim.

3. Rau lub paj hlwb: yuav muaj cov tsos mob ntawm kev zoo siab.

4. Nws tuaj yeem txo cov qe ntshav liab thiab cov qe ntshav dawb.

5. Yuav muaj kev kub ntxhov, ua rau muaj qhov tshwm sim ntawm kev qaug zog, thiab tag nrho cov roj cholesterol tseem yuav nce.

Cov kev ceev faj

1. Thaum noj cov khoom no rau lub sijhawm ntev, nws yuav tsum tau kuaj xyuas lub siab ua haujlwm xws li GOT thiab GPT raws sijhawm.

2. Txij li kev nyab xeeb ntawm cov khoom no rau cov poj niam cev xeeb tub tsis tau txiav txim siab, nws yog txwv tsis pub rau cov poj niam cev xeeb tub.

3. Cov khoom no tuaj yeem dhau mus rau cov kua mis, yog li cov poj niam pub niam mis yuav tsum siv ceev faj.

Yuav tiv tauj peb li cas?

Peb lub tuam txhab tshwj xeeb hauv kev cog qoob loo, txiv hmab txiv ntoo thiab zaub hmoov, tshuaj pleev ib ce, ntsiav tshuaj candies, thiab lwm yam khoom. Nws yog tus kws tshaj lij kev muag khoom. Peb tau koom nrog hauv kev lag luam no tau ntau xyoo thiab muaj kev paub dhau los thiab cov peev txheej. Yog tias koj xav tau cov khoom lag luam zoo thiab tsis tshua muaj nqi muag khoom ncaj qha, koj tuaj yeem tiv tauj peb los ntawm lub vev xaib thoob ntiaj teb lossis email.

Peb tus email chaw nyob yogella.zhang@huilinbio-tech.com ib, thiab koj tuaj yeem tuaj xyuas lub Hoobkas los ntawm lub tuam txhab chaw nyob, Chav 706, Tsev B, Fengze Science, thiab Technology Park, No. 170 West Street, Yanta District, Xi'an City, Shaanxi Province. Tam sim no peb muagIdebenone hmoovkub, uas yog nyob rau hauv Tshuag; yog tias koj xav paub nws tus nqi, koj tuaj yeem tiv tauj peb los ntawm txoj kev saum toj no, thiab peb tuaj yeem muab tus nqi tshwj xeeb rau koj.