Ib qho 24-lub lim tiam randomized ob-dig muag placebo-tswj sim qhia tau hais tias ib qho aqueous extract los ntawm Coffea arabica pulp txo qis LDL cholesterol, triglycerides, thiab tag nrho cov roj cholesterol thaum nce HDL cholesterol, nrog ntxiv cov txiaj ntsig ntawm qhov hnyav thiab insulin tsis kam.
Lub Tsib Hlis 20, 2026- Kev sim tshuaj ntsuam xyuas luam tawm hauvFrontiers nyob rau hauv Khoom noj khoom haustau pom tias ib qho aqueous extract los ntawmKas fes arabica pulp(CPE) tuaj yeem txhim kho lipid profile, txo lub cev hnyav, thiab txhim kho cov tshuaj insulin hauv cov neeg rog rog nrog cov roj cholesterol siab.
Lub nra ntawm kev rog thiab xav tau kev xaiv ntuj
Kev rog rog yog cuam tshuam nrog dyslipidemia thiab mob ntev, ua rau muaj kev pheej hmoo ntawm kab mob plawv, metabolic syndrome, ntshav qab zib hom 2, thiab kab mob siab rog. Kev txo qis lipoprotein tsawg-density lipoprotein (LDL) cov roj cholesterol yog ib lub tswv yim pom zoo los txo cov kev pheej hmoo plawv.
"Tam sim no, muaj ntau txoj hauv kev los txo qhov hnyav, thiab kev siv cov khoom noj khoom haus ntuj tau dhau los ua kev xaiv nrov," cov kws tshawb fawb tau sau tseg. "Yog li ntawd, txoj kev tshawb no tsom mus rau cov khoom ntuj tsim los txo cov kev mob tshwm sim tsawg kawg nkaus."
Arabica kas fes pulp - cov tawv nqaij thiab cov mucilage tshem tawm thaum lub sij hawm arabica kas fes ua - yog nplua nuj nyob rau hauv bioactive compounds nrog rau chlorogenic acid, polyphenols, thiab caffeine, uas muaj anti-inflammatory, antioxidant, thiab lipid-txo cov khoom. Txawm hais tias cov tebchaw no tseem muaj nyob hauv lwm hom kas fes (xws li, robusta), cov ntaub ntawv pov thawj kho mob rau hnub tim yog tshwj xeeb rau arabica pulp extract.
Tshawb nrhiav kev tsim thiab kev tshawb pom tseem ceeb
Pab pawg tshawb fawb, coj los ntawm Thaib cov tsev kawm ntawv, tau tso npe rau 79 cov neeg laus rog rog (BMI Ntau dua lossis sib npaug li 25 kg / m²) nrog cov roj cholesterol siab LDL (Ntau dua lossis sib npaug li 130 mg / dL). Cov neeg koom nrog tau raug muab tso tseg kom haus 75 mL ntawm arabica CPE cov khoom lag luam lossis cov placebo zoo ib yam ob zaug hauv ib hnub rau 24 lub lis piam, nrog rau kev noj zaub mov tsis muaj calorie thiab kev tawm dag zog tsis tu ncua.
Cov khoom CPE tau raug tshav kub-kho kom tshem tawm cov kab mob thaum khaws cia cov tshuaj bioactive, thiab pom tau tias muaj ntau dua polyphenols, chlorogenic acid, thiab caffeine ntau dua li cov placebo, muaj zog antioxidant.
Tom qab 24 lub lis piam, pawg arabica CPE ua tiav:
- LDL cov cholesterol- txo los ntawm 14.9% los ntawm cov hauv paus
- Triglycerides- txo los ntawm 18.9%
- Tag nrho cov cholesterol- txo los ntawm 8.0%
- HDL cov roj cholesterol- nce 6.0%
Tom qab kev hloov kho rau lub hauv paus lipid qhov tseem ceeb, pawg CPE tau pom qhov txo qis hauv tag nrho cov roj (-6.3% vs. −2.4%, p=0.048), LDL cholesterol (−13.7% vs. −7.1%, p=0.01), thiab qhov txo qis hauv triglycerides (-10%) piv rau −12% p {{1}% 12}; cov tshuaj placebo. HDL cholesterol tau nce hauv pawg CPE tab sis txo qis hauv pawg placebo tom qab hloov kho (+7.1% vs. −5.0%, p < 0.0001).
Kev txhim kho tau tshaj tawm hauv cov poj niam thiab cov neeg laus dua. Tsis tas li ntawd, pawg CPE tau ntsib kev txo qis hauv lub cev hnyav, BMI, thiab lub duav ncig, nrog rau kev txhim kho insulin tsis kam (homeostatic qauv kev ntsuas ntawm insulin tsis kam, HOMA-IR, txo los ntawm 16.7% los ntawm cov hauv paus ntsiab lus) thiab stabilized ntshav qabzib qib. Hauv qhov sib piv, cov placebo pab pawg pom cov kev hloov pauv tsis zoo ntawm cov metabolism. CPE tsis tau hloov pauv tag nrho lub cev muaj roj ntau, thiab nws cov teebmeem tiv thaiv kev mob tshwm sim, nrog kev txhim kho tseem ceeb tsuas yog rau C-reactive protein (CRP).
Cov duab hauv kev siv [1]
Tswv yim mechanisms ntawm kev ua
Cov kws tshawb fawb tau tshawb xyuas cov txheej txheem los ntawm kev sim hauv vitro. Lawv pom tias arabica CPE hloov pauv tus cwj pwm ntawm cov roj cholesterol los ntawm kev nce qhov loj ntawm cov roj cholesterol micelles, uas tuaj yeem tsim kev cuam tshuam tsis zoo los txo cov roj cholesterol hauv plab, thaum xaiv khi rau qee cov kua tsib acids, tawm tswv yim cuam tshuam nrog cov roj cholesterol enterohepatic ncig.
Pab neeg no hais tias arabica CPE lub hauv paus txheej txheem cuam tshuam nrog inhibiting plab hnyuv nqus cov roj cholesterol los ntawm kev cuam tshuam kev tsim micelle, txo cov kua tsib kua qaub, thiab muaj peev xwm thaiv NPC1L1 thauj cov proteins hauv plab hnyuv epithelial hlwb. Cov extract kuj tseem tuaj yeem txhawb nqa lub siab lipolysis thiab nce kev siv zog.
Tsis zoo li qee cov khoom lag luam lipid-txo cov khoom uas twb muaj lawm (xws li cov poov xab liab cov tshuaj ntxiv uas muaj monacolin K), arabica CPE muaj qhov muaj txiaj ntsig zoo los ntawm nws txoj kev tiv thaiv kab mob hauv plab hnyuv, pab txo qis cov plab hnyuv permeability tshwm sim los ntawm qib qis.
Cov duab hauv kev siv [1]
Kev nyab xeeb thiab kev pom
Qhov kev sim no tau tshaj tawm tsis muaj qhov sib txawv ntawm cov xwm txheej tsis zoo ntawm cov pab pawg arabica CPE thiab cov placebo, qhia tias muaj kev zam tau zoo tshaj 24 lub lis piam.
"CPE cov khoom lag luam nplua nuj hauv polyphenols thiab chlorogenic acids pab txhim kho cov ntshav lipid profile hauv cov neeg laus rog rog nrog hyperlipidemia, txo qis LDL roj cholesterol, tag nrho cov cholesterol, thiab triglycerides thaum nce HDL cholesterol," cov kws tshawb fawb xaus lus.
Lawv tau lees paub cov kev txwv, suav nrog lub sijhawm kho mob luv luv, cov neeg koom nrog tsawg, thiab kev tshawb nrhiav qhov xwm txheej ntawm txoj kev tshawb no. Cov kev tshawb fawb soj ntsuam loj dua, ntev dua yuav tsum tau ua kom paub tseeb tias kev nyab xeeb mus ntev thiab kev ua tau zoo ntawm arabica kas fes pulp extract supplementation.
Kev siv
[1] Buranapin, S., Ontawong, A., Vaddhanaphuti, C., Inthaphan, S., Inchai, J., Saithong, S., Narkprasom, K., Fuangchoom, S., & Amonlerdpison, D. (2026). Muaj peev xwm lipid-txo cov teebmeem ntawm Coffea arabica pulp extract khoom nyob rau hauv cov neeg mob hyperlipidemia-obese: Ib qho randomized ob-dig muag placebo-tswj sim.Frontiers nyob rau hauv Khoom noj khoom haus, 13, 1755054. https://doi.org/10.3389/fnut.2026.1755054
Cov khoom muaj feem xyuam los ntawm peb cov khoom
Thaum cov pov thawj kho mob saum toj no yog tshwj xeeb rau Coffea arabica pulp extract, bioactive compounds tseem ceeb nyob rau hauv txoj kev tshawb no -tshwj xeeb yog chlorogenic acids thiab polyphenols- kuj pom nyob rau hauv lwm yam siab - zoo botanical cov khoom xyaw. Tshawb nrhiav peb cov kev xaiv cov khoom siv raw rau cov khoom noj khoom haus thiab kev siv ntxiv:
- Chlorogenic Acid Hmoov
- Green Coffee Bean Extract
- Ntsuab tshuaj yej Extract hmoov
- Burdock hauv paus Extract hmoov
- Chicory Inulin Hmoov
- Coffee Txiv Hmab Txiv Ntoo Extract
Cov khoom no tsis zoo ib yam li arabica pulp extract siv nyob rau hauv qhov kev sim hais thiab tsis tau raug soj ntsuam xyuas kom rov ua dua nws cov txiaj ntsig tshwj xeeb.
[Saib tag nrho cov Extracts →]