Xi'an Huilin Bio-Tech Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm chenodeoxycholic acid hmoov hauv Suav teb. Nrog kev paub dhau los, peb tau cog lus los muab cov khoom lag luam zoo nrog cov nqi sib tw. Thov koj xav tias dawb rau cov lag luam wholesale bulk ntshiab chenodeoxycholic acid hmoov rau muag ntawm no los ntawm peb lub hoobkas.
Taw qhia rau Chenodeoxycholic Acid
Chenodeoxycholic acid (CDCA)yog ib qho tshwm sim ntawm cov kua tsib acid hauv tib neeg. Nws yog dav siv los ua Cov Khoom Siv Tshuaj Ua Haujlwm (API) hauv cov tshuaj hauv qhov ncauj rau kev sib cais ntawm cov roj cholesterol hauv lub gallstones thiab rau kev kho mob ntawm qee yam tsis tshua muaj kua tsib acid synthesis, xws li cerebrotendinous xanthomatosis (CTX). CDCA ua haujlwm los ntawm inhibiting hepatic cholesterol thiab cholic acid synthesis, uas maj mam txo cov roj cholesterol saturation thiab tso cai rau gallstones kom yaj thaum lub sij hawm.
CDCA yog thawj zaug pom zoo los ntawm US FDA hauv 1983 rau kev tshem tawm cov pob zeb hauv lub gallstone thiab tau txais kev pom zoo los ntawm European Medicines Agency (EMA) hauv xyoo 2017 rau kev yug me nyuam ntawm thawj cov kua tsib acid synthesis.
Certificate of Analysis (COA)
| Parameter | Specification | Yam tshwm sim |
|---|---|---|
| Qhov tshwm sim | Dawb rau tawm -dawb crystalline hmoov | Ua raws |
| Assay (ntawm qhuav hauv paus) | 98.0% – 102.0% | 99.2% |
| Kev txheeb xyuas (HPLC) | Lub sijhawm khaws cia yog qhov kev siv tus qauv | Ua raws |
| Yam khoom muaj feem | Txhua tus neeg impurity Tsawg dua lossis sib npaug li 0.5%; Tag nrho impurities Tsawg dua lossis sib npaug li 1.5% | 0.78% (tag nrho) |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.6% |
| Residue ntawm Ignition | Tsawg dua lossis sib npaug li 0.2% | 0.1% |
| Hnyav Hlau | Tsawg dua lossis sib npaug li 20 ppm | Ua raws |
| Specific Optical Rotation | +11℃rau +13℃(c=1, CHCl₃) | +12.2 degree |
| Melting Point | 165-167 degree | 166 degree |
| Particle Loj Distribution | Raws li cov neeg siv khoom tshwj xeeb (micronized muaj) | D90 Tsawg dua lossis sib npaug li 180 µm |
| Residual Solvents | Ua tau raws li ICH Q3C cov cai | Ua raws |
| Microbial txwv | TAMC Tsawg dua lossis sib npaug li 1000 cfu / g; tsis muaj cov kab mob tshwj xeeb | Ua raws |
Nco tseg: Batch- tshwj xeeb COA muaj nyob rau thaum thov.
Cov txiaj ntsig ntawm Chenodeoxycholic Acid
- Ib txwm tshwm sim thawj cov kua tsib acid- CDCA yog ib qho physiological bile acid ib txwm tsim nyob rau hauv tib neeg lub siab los ntawm cov roj cholesterol, ua rau nws zoo -tolerated thiab biologically haum API
- Pov thawj gallstone dissolution therapy- CDCA yog thawj tus neeg sawv cev tshaj tawm hauv Asmeskas kev ua lag luam rau kev kho mob ntawm cov roj cholesterol hauv lub gallstones. Cov kev tshawb fawb soj ntsuam pom tau tias kev noj tshuaj txaus (Ntau dua lossis sib npaug li 15 mg / kg / hnub) ua tiav cov lus teb txog li 83% hauv cov neeg mob xaiv.
- FXR nuclear receptor activation- CDCA yog endogenous ligand rau farnesoid X receptor (FXR), tus tswj hwm tseem ceeb ntawm cov kua tsib kua qaub thiab cov roj cholesterol metabolism. Cov txheej txheem no underlies nws cov teebmeem kev kho mob hauv cov cholesterol homeostasis
- Orphan tshuaj npe rau cov kab mob tsawg- CDCA yog qhia rau kev kho mob ntawm cerebrotendinous xanthomatosis (CTX), ib qho tsis tshua muaj kev cuam tshuam ntawm cov kua tsib acid synthesis vim sterol 27-hydroxylase deficiency.
- Zoo -tsim kev cai lij choj- FDA- pom zoo txij li xyoo 1983 thiab EMA- pom zoo txij li xyoo 2017, nrog cov ntaub ntawv pov thawj kev nyab xeeb thiab kev ua tau zoo tshaj li plaub xyoos ntawm kev siv tshuaj kho mob
- Versatile API rau ntau formulations- Muaj los ua hmoov rau kev tsim ua yeeb yaj kiab- cov ntsiav tshuaj coated (250 mg) thiab cov tshuaj ntsiav nyuaj, nrog rau kev xaiv ntau npaum li cas
- iab -tasting dawb hmoov- Cov khoom siv lub cev sib xws (dawb hmoov, crystalline thiab amorphous hais) txhawb kev tsim cov txheej txheem txhim khu kev qha
Chenodeoxycholic Acid siv rau dab tsi?
Pharmaceutical Applications (Human Medicine):
- Active Pharmaceutical Ingredient (API):Formulated rau hauv cov ntaub ntawv ntawm qhov ncauj noj, nrog rau zaj duab xis -coated ntsiav tshuaj (250 mg) thiab tawv capsules
- Gallstone Dissolution:Qhia rau kev sib cais ntawm radiolucent cholesterol gallstones hauv cov neeg mob uas pom lub gallbladders. CDCA inhibits hepatic cholesterol synthesis, maj mam desaturating bile thiab dissolving pob zeb cholesterol. Nws tsis cuam tshuam rau radiopaque (calcified) gallstones lossis radiolucent bile pigment pob zeb
- Cerebrotendinous Xanthomatosis (CTX):Thawj -Txoj kab hloov kho rau kev yug me nyuam tsis raug ntawm thawj cov kua tsib acid synthesis vim sterol 27-hydroxylase deficiency hauv cov neeg laus thiab menyuam yaus txij li 1 lub hlis. Qhov ncauj CDCA (750 mg / hnub) txo cov cholestanol tsub zuj zuj thiab tiv thaiv kev puas hlwb.
- Bile Acid Synthesis Disorders:Kev kho ntawm congenital thawj bile acid synthesis deficiencies
- Orphan Tshuaj Indication:CDCA muaj cov tshuaj me nyuam ntsuag rau kev kho mob ntawm CTX hauv EU thiab lwm thaj chaw
Nco tseg: Txhua daim ntawv thov yuav tsum ua raws li cov cai tswj hwm hauv zos, suav nrog kev pom zoo thiab kev tso cai ua lag luam. CDCA yuav tsum tau tshwj tseg rau cov neeg mob uas tau xaiv ua tib zoo thiab kev kho mob yuav tsum tau nrog rau kev soj ntsuam kom zoo rau kev hloov pauv ntawm daim siab ua haujlwm.
Cov lus nug nquag nug (FAQ)
Q: Qhov txawv ntawm chenodeoxycholic acid thiab ursodeoxycholic acid yog dab tsi?
A: Ob leeg yog thawj cov kua tsib acids, tab sis lawv txawv ntawm hydroxyl pawg stereochemistry. CDCA muaj 3 ,7 -dihydroxy configuration, hos UDCA muaj 3,7 -dihydroxy configuration (the 7-epimer of CDCA). CDCA feem ntau yog siv rau kev sib cais ntawm lub gallstone thiab CTX, thaum UDCA feem ntau siv rau cov kab mob biliary cholangitis.
Q: Dab tsi yog qhov solubility profile ntawm CDCA?
A: CDCA yog dawb soluble hauv methanol, acetone, thiab acetic acid, tab sis xyaum insoluble hauv dej. Cov cuab yeej no yuav tsum tau txiav txim siab thaum tsim kho.
Q: Dab tsi yog patent txheej txheem ntawm API no?
A: Chenodeoxycholic acid yog tawm -patent nyob rau hauv feem ntau cov khw loj. Cov neeg siv khoom yog lub luag haujlwm rau kev ua lawv tus kheej txoj kev ywj pheej- los - ua haujlwm tshuaj xyuas rau cov qauv tshwj xeeb.
Q: Dab tsi yog qhov tseem ceeb impurities los saib xyuas?
A: Cov impurities tseem ceeb suav nrog cov kua tsib kua qaub xws li lithocholic acid thiab lwm yam dihydroxy bile acid isomers. Peb COA muab tag nrho impurity profiles ib specifications.
Peb Qhov Zoo
Koj tus kws tshaj lij kev tsim khoom & Sourcing tus khub
Peb yog ntau tshaj li tus neeg muag khoom - peb yog cov khoom lag luam sib txuas ua ke rau siab - cov khoom xyaw zoo, cov qauv kev cai, thiab cov khoom tiav thoob plaws ntau qhov kev lag luam.
Nrog rau ntau xyoo ntawm kev paub hauv cov nroj tsuag extracts, khoom noj khoom haus additives, cosmetic raw cov ntaub ntawv, thiab cov khoom noj khoom haus, peb pab neeg coj cov kev txawj ntse txawj ntse thiab kev ua lag luam kev pom zoo rau txhua qhov kev koom tes.
01. Ntau yam khoom lag luam
Peb muab ntau yam khoom lag luam, suav nrog cov khoom noj khoom haus ntxiv, cov nroj tsuag rho tawm, txiv hmab txiv ntoo & zaub hmoov, tshuaj pleev ib ce, thiab cov khoom xyaw ua zaub mov.
- Raw Khoom:High -cov khoom xyaw purity rau zaub mov, dej haus, ntxiv, thiab kev siv tshuaj pleev ib ce.
- Cov khoom tiav:Hauv -tsev tsim cov tshuaj ntsiav, softgels, gummies, kua tee, thiab hmoov sib tov.
- Label Design & Ntim:Custom branding tailored rau koj lub hom phiaj ua lag luam.
- Formulation & R & D:Cov kws tshaj lij kev txhawb nqa los tsim cov kev cai sib xyaw, cov qauv tsim muaj, thiab cov khoom tsim tshiab.
- Ntiaj teb no Logistics:Txhim khu kev xa khoom, cov ntaub ntawv, thiab kev pabcuam kev lis kev cai.
04. Kev Ua Haujlwm Zoo
Kev nruj nruj raws li cGMP cov qauv thiab tag nrho cov kev cai pob tshab. Peb nyob twj ywm tam sim no nrog cov kev cai thoob ntiaj teb, suav nrog FDA GRAS, EFSA, thiab lwm yam kev cai hauv cheeb tsam, kom ntseeg tau tias koj cov khoom ua tau raws li cov qauv kev nyab xeeb siab tshaj plaws thiab ua raws.
Yuav tiv tauj li cas
Hu rau peb pab neeg muag khoom los tham txog kojChenodeoxycholic Acid Hmoovkev xav tau.
Thov hu rau peb ntawmella.zhang@huilinbio-tech.com.
Cov ntaub ntawv
[1] Chenodiol ntsiav tshuaj, 250 mg.DailyMed, US National Library of Medicine.
[5] Chenodeoxycholic Acid.PubChem, National Center for Biotechnology Information.
Tsis lees paub
Cov khoom no yog API / nruab nrab rau kev tsim khoom nkaus xwb, tsis yog rau tib neeg noj. Cov ntaub ntawv yog B2B nkaus xwb, tsis yog cov lus qhia kho mob. Cov neeg yuav khoom yuav tsum ua raws li cov cai thiab muaj kev pom zoo. CDCA yuav tsum tau saib xyuas lub siab ua haujlwm vim muaj kev pheej hmoo siab hepatotoxicity. Cov lus qhia tshwj xeeb tuaj yeem hloov pauv; thov cov ntaub ntawv tam sim no.
Cim npe nrov: chenodeoxycholic acid hmoov, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, ntuj, zoo, Tshuag, kev muag
