Xi'an Huilin Bio-Tech Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm hyodeoxycholic acid hmoov hauv Suav teb. Nrog kev paub dhau los, peb tau cog lus los muab cov khoom lag luam zoo nrog cov nqi sib tw. Thov koj xav tias dawb rau cov lag luam wholesale bulk ntshiab hyodeoxycholic acid hmoov muag ntawm no los ntawm peb lub hoobkas.
Taw qhia rau Hyodeoxycholic Acid
Hyodeoxycholic acid (HDCA)yog ib qho tshwm sim ntawm cov kua tsib acid pom nyob rau hauv siab concentrations hauv npua cov kua tsib. Nws muaj cov qauv tshuaj tshwj xeeb uas ua rau nws sib nrug ntawm lwm cov kua tsib xws li chenodeoxycholic acid (CDCA) thiab ursodeoxycholic acid (UDCA).
HDCA tau txais kev txaus siab rau nws cov txiaj ntsig kev noj qab haus huv. Nws pab tswj cov metabolism thiab txo qhov mob los ntawm nws cov teebmeem ntawm cov receptors tseem ceeb hauv lub cev. Nws kuj tau pom tias yuav ua rau muaj kev ntxhov siab ntau dhau.
Thawj zaug cais tawm ntawm cov kua tsib nyob rau hauv lub xyoo pua 20th, HDCA tau pib kawm rau nws lub peev xwm los tiv thaiv cov cholesterol gallstones. Tsis ntev los no, kev tshawb fawb tau nthuav dav los tshawb txog nws lub peev xwm hauv kev noj qab haus huv hauv metabolic, tswj kev mob, thiab txawm tias kev tshawb fawb txog qog noj ntshav.
Certificate of Analysis (COA)
| Parameter | Specification | Yam tshwm sim |
|---|---|---|
| Qhov tshwm sim | Dawb rau tawm -dawb crystalline hmoov | Ua raws |
| Assay (ntawm qhuav hauv paus) | Ntau dua lossis sib npaug li 98.0% | 98.5% |
| Kev txheeb xyuas (HPLC) | Lub sijhawm khaws cia yog qhov kev siv tus qauv | Ua raws |
| Yam khoom muaj feem | Txhua tus neeg impurity Tsawg dua lossis sib npaug li 1.0%; Tag nrho impurities Tsawg dua lossis sib npaug li 2.0% | 0.95% (tag nrho) |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.5% |
| Residue ntawm Ignition | Tsawg dua lossis sib npaug li 0.2% | 0.1% |
| Hnyav Hlau | Tsawg dua lossis sib npaug li 20 ppm | Ua raws |
| Specific Optical Rotation | +6℃rau +10℃(c=2 hauv ethanol) | +8.2 degree |
| Melting Point | 196-201 degree | 199 degree |
| Particle Loj Distribution | Raws li cov neeg siv khoom specifications | D90 Tsawg dua lossis sib npaug li 180 µm |
| Residual Solvents | Ua tau raws li ICH Q3C cov cai | Ua raws |
| Microbial txwv | TAMC Tsawg dua lossis sib npaug li 1000 cfu / g; tsis muaj cov kab mob tshwj xeeb | Ua raws |
Nco tseg: Batch- tshwj xeeb COA muaj nyob rau thaum thov.
Cov txiaj ntsig Hyodeoxycholic Acid
- Ib txwm tshwm sim Secondary bile acid- HDCA yog ib qho physiological bile acid uas tsim los ntawm plab hnyuv microbial metabolism, ua rau nws muaj kev sib xyaw ua ke lom neeg.
- FXR thiab TGR5 dual receptor agonist- HDCA ib txhij qhib lub farnesoid X receptor (FXR) thiab G protein -coupled bile acid receptor TGR5, ua kom dav metabolic thiab tiv thaiv - cov teebmeem inflammatory
- Anti-cov khoom muaj zog- HDCA inhibits kev ua kom ntau dhau ntawm cov kab mob macrophages los ntawm kev sib tw thaiv lipopolysaccharide khi rau TLR4 / MD2 receptor complex, ua haujlwm raws li endogenous inhibitor ntawm inflammatory signaling.
- Gallstone tiv thaiv- HDCA tiv thaiv kev tsim cov cholesterol gallstones los ntawm kev tshem tawm cov lus tawm tswv yim inhibition ntawm HMG-CoA reductase (tus nqi- txwv enzyme ntawm cov roj cholesterol synthesis) thiab tiv thaiv kev hloov pauv ntawm cov roj cholesterol los ntawm cov kua crystalline theem mus rau cov khoom siv lead ua.
- Zoo -absorbed nrog ib tug haum metabolic profile- HDCA yog nqus tau zoo los ntawm tib neeg txoj hnyuv thiab tsis tsim cov lithocholic acid, ib qho hepatotoxic bile acid metabolite.
- Muaj peev xwm kho tau- Cov kev tshawb fawb tsis ntev los no tau pom tias HDCA lub peev xwm hauv kev tiv thaiv kab mob qog nqaij hlav hauv plab los ntawm FXR / EREG / EGFR axis, neuropathic mob nyem los ntawm kev ua kom FXR, thiab tiv thaiv kab mob sepsis
- Versatile API rau ntau daim ntawv thov- Muaj raws li qib siab -purity hmoov rau kev tsim tshuaj, tshuaj tshawb fawb, thiab cov khoom xyaw ntxiv
Hyodeoxycholic Acid siv rau dab tsi?
Pharmaceutical and Research Applications:
- Active Pharmaceutical Ingredient (API):HDCA yog siv los ua API lossis tshuaj nruab nrab hauv kev tsim tshuaj rau cov kab mob metabolic thiab inflammatory
- Gallstone Kev Tiv Thaiv Kev Tshawb Fawb:HDCA tiv thaiv kev tsim cov cholesterol los ntawm kev hloov cov roj cholesterol synthesis thiab cov kua tsib muaj pes tsawg leeg
- Kev Tshawb Fawb Txog Kab Mob Metabolic:HDCA tau kawm txog nws lub luag haujlwm hauv glucose homeostasis, lipid metabolism, thiab FXR / TGR5-mediated metabolic regulation
- Anti-Inflammatory Drug Development:HDCA's TLR4 inhibitory mechanism ua rau nws muaj kev vam meej tus neeg sib tw rau sepsis thiab inflammatory kab mob tshawb fawb
- Kev Tshawb Fawb Cancer:Cov kev tshawb fawb tsis ntev los no tau txheeb xyuas HDCA raws li qhov muaj peev xwm tiv thaiv -tus neeg mob qog noj ntshav los ntawm kev ua kom FXR
- Analytical Reference Standard:HDCA yog siv los ua tus qauv siv rau cov kua qaub kua qaub profileing los ntawm LC-MS txoj kev
Daim ntawv thov kev noj zaub mov ntxiv:
HDCA yog siv los ua ib qho khoom xyaw hauv cov tshuaj kho mob ntxiv rau lub hom phiaj kev noj qab haus huv metabolic thiab txhawb kev mob
Nco tseg: Txhua daim ntawv thov yuav tsum ua raws li cov cai tswj hwm hauv zos, suav nrog kev pom zoo thiab kev tso cai ua lag luam.
Kev sib piv ntawm Bile Acid: HDCA, CDCA & UDCA
| Khoom | CDCA (Chenodeoxycholic Acid) | HDCA (Hyodeoxycholic Acid) | UDCA (Ursodeoxycholic Acid) |
|---|---|---|---|
| CAS Nr | 474-25-9 | 83-49-8 | 128-13-2 |
| Molecular Formula | C₂₄H₄₀O₄ | C₂₄H₄₀O₄ | C₂₄H₄₀O₄ |
| Molecular Luj | 392.57 g / mol | 392.57 g / mol | 392.57 g / mol |
| Tshuaj npe | 3,7-dihydroxy-5-cholan-24-oic acid | 3,6-dihydroxy-5-cholan-24-oic acid | 3,7-dihydroxy-5-cholan-24-oic acid |
| Qhov Chaw Tseem Ceeb | Poultry bile (nqaij qaib, duck, goose) | Pig bile (cov kua tsib tseem ceeb) | Dais bile (tseem); Tam sim no semi-synthetic los ntawm CDCA |
| Bile Acid Hom | Primary kua tsib acid | Secondary kua tsib acid | Secondary kua tsib acid |
| Hydroxyl txoj hauj lwm | 3 , 7 | 3 , 6 | 3 , 7 |
| Thawj Mechanism | Txo cov roj cholesterol hauv siab thiab cholic acid synthesis; txo biliary cholesterol saturation | Ua kom FXR thiab TGR5; tswj lipid metabolism; inhibits TLR4-mediated mob | Tsim cov kua-crystalline txheej ntawm cov roj cholesterol los txhawb kev sib cais; tsis inhibit cholesterol synthesis |
| Kev siv tshuaj kho mob tseem ceeb | Dissolution ntawm radiolucent cholesterol gallstones; precursor rau UDCA synthesis | Kev tswj hwm metabolic; Kev tshawb nrhiav tshuaj tiv thaiv; kev tiv thaiv kab mob gallstone | Dissolution ntawm cov cholesterol gallstones; thawj biliary cholangitis (PBC); kua tsib reflux gastritis; thawj sclerosing cholangitis |
| Cov nyhuv choleretic | Nruab nrab | Tsis muaj zog (yuav luag tsis muaj) | Muaj zog tshaj |
| Cov teebmeem | Feem ntau ua rau raws plab (txog 50% ntawm cov neeg mob); nce transaminases hauv qee kis; contraindicated nyob rau hauv cev xeeb tub / lactation | Ua tau zoo; tsis tau qhia tias mob raws plab | Tsawg qhov tshwm sim ntawm raws plab; muaj kev nyab xeeb rau siv thaum cev xeeb tub / lactation |
| Clinical Status | Tsawg siv niaj hnub no vim muaj kev phiv | Feem ntau siv rau lipid-txo qis, tiv thaiv kab mob, thiab kev tshawb fawb siv | Feem ntau siv cov kua tsib acid tshuaj hauv kev kho mob |
Kev Sib Raug Zoo:
CDCA, HDCA, thiab UDCA yog qhov chaw thiab stereoisomers - txhua tus sib koom tib lub qauv molecular (C₂₄H₄₀O₄) tab sis txawv ntawm txoj hauj lwm (6 vs . 7 ) lossis stereochemistry (7 vs . 7 ) ntawm pawg hydroxyl. UDCA yog 7-epimer ntawm CDCA.
Cov lus nug nquag nug (FAQ)
Q: Dab tsi yog qhov purity theem ntawm koj Hyodeoxycholic Acid Powder?
A: Peb HDCA Hmoov feem ntau ua tiav ntau dua lossis sib npaug rau 98.0% purity ntawm lub hauv paus tsis muaj dej. Batch- tshwj xeeb COA yog muab rau txhua qhov khoom xa tuaj.
Q: Qhov txawv ntawm HDCA, CDCA, thiab UDCA yog dab tsi?
A: HDCA (3 ,6) txawv ntawm CDCA (3 ,7) thiab UDCA (3,7) nyob rau hauv hydroxyl txoj hauj lwm. HDCA tsuas yog ib qho nrog 6 - pab pawg hydroxy thiab ua rau ob qho tib si FXR thiab TGR5, muab nws qhov tshwj xeeb metabolic thiab tiv thaiv - cov khoom ua rau mob.
Q: Koj siv txoj kev tshuaj ntsuam xyuas dab tsi rau kev tswj kom zoo?
A: Peb siv HPLC rau kev soj ntsuam thiab lwm yam tshuaj, ntxiv rau kev sib hloov kho qhov muag, melting point, poob ntawm ziab, residue ntawm ignition, thiab hnyav hlau kuaj. Kev txheeb xyuas tau lees paub los ntawm HPLC lub sijhawm khaws cia tawm tsam tus qauv siv.
Q: Dab tsi yog cov impurities tseem ceeb hauv HDCA?
A: Cov impurities tseem ceeb suav nrog lwm cov kua tsib acid isomers xws li hyocholic acid, chenodeoxycholic acid, thiab lithocholic acid. Tag nrho cov impurities raug tswj kom tsawg dua lossis sib npaug li 2.0% nrog rau ib tus neeg impurity Tsawg dua lossis sib npaug li 1.0%.
Q: HDCA puas tuaj yeem siv ua ke nrog lwm cov kua qaub?
A: Yog, HDCA tuaj yeem ua ke nrog lwm cov kua qaub los yog cov khoom ntxiv. Kev tshawb fawb txog kev sib raug zoo thiab kev tsim kho kom zoo yog pom zoo kom tau txais txiaj ntsig zoo tshaj plaws.
Q: Dab tsi yog qhov ntau npaum li cas rau HDCA?
A: Hauv kev tshawb fawb soj ntsuam, ntau npaum li cas ntawm 250-750 mg / hnub nyob ntawm qhov qhia. Peb cov khoom yog rau kev tsim khoom thiab kev tshawb fawb siv nkaus xwb, tsis yog tib neeg noj.
Q: HDCA piv rau CDCA li cas ntawm cov kev mob tshwm sim?
A: Tsis zoo li CDCA, HDCA feem ntau tsis ua rau raws plab. Nws yog qhov zoo- zam thiab tsis tsim cov tshuaj lithocholic acid, ib qho hepatotoxic bile acid metabolite.
Peb Qhov Zoo
Koj tus kws tshaj lij kev tsim khoom & Sourcing tus khub
Peb yog ntau tshaj li tus neeg muag khoom - peb yog cov khoom lag luam sib txuas ua ke rau siab - cov khoom xyaw zoo, cov qauv kev cai, thiab cov khoom tiav thoob plaws ntau qhov kev lag luam.
Nrog rau ntau xyoo ntawm kev paub hauv cov nroj tsuag extracts, khoom noj khoom haus additives, cosmetic raw cov ntaub ntawv, thiab cov khoom noj khoom haus, peb pab neeg coj cov kev txawj ntse txawj ntse thiab kev ua lag luam kev pom zoo rau txhua qhov kev koom tes.
01. Ntau yam khoom lag luam
Peb muab ntau yam khoom lag luam, suav nrog cov khoom noj khoom haus ntxiv, cov nroj tsuag rho tawm, txiv hmab txiv ntoo & zaub hmoov, tshuaj pleev ib ce, thiab cov khoom xyaw ua zaub mov.
- Raw Khoom:High -cov khoom xyaw purity rau zaub mov, dej haus, ntxiv, thiab kev siv tshuaj pleev ib ce.
- Cov khoom tiav:Hauv -tsev tsim cov tshuaj ntsiav, softgels, gummies, kua tee, thiab hmoov sib tov.
- Label Design & Ntim:Custom branding tailored rau koj lub hom phiaj ua lag luam.
- Formulation & R & D:Cov kws tshaj lij kev txhawb nqa los tsim cov kev cai sib xyaw, cov qauv tsim muaj, thiab cov khoom tsim tshiab.
- Ntiaj teb no Logistics:Txhim khu kev xa khoom, cov ntaub ntawv, thiab kev pabcuam kev lis kev cai.
04. Kev Ua Haujlwm Zoo
Kev nruj nruj raws li cGMP cov qauv thiab tag nrho cov kev cai pob tshab. Peb nyob twj ywm tam sim no nrog cov kev cai thoob ntiaj teb, suav nrog FDA GRAS, EFSA, thiab lwm yam kev cai hauv cheeb tsam, kom ntseeg tau tias koj cov khoom ua tau raws li cov qauv kev nyab xeeb siab tshaj plaws thiab ua raws.
Yuav tiv tauj li cas
Hu rau peb pab neeg muag khoom los tham txog kojHyodeoxycholic Acid Hmoovkev xav tau.
Thov hu rau peb ntawmella.zhang@huilinbio-tech.com.
Cov ntaub ntawv
Tsis lees paub
Rau kev tsim khoom thiab kev tshawb fawb siv xwb. Tsis yog rau tib neeg noj. B2B cov ntaub ntawv - tsis yog cov lus qhia kho mob. Cov neeg yuav khoom yuav tsum ua raws li cov cai thiab tau txais kev pom zoo. Cov lus qhia tshwj xeeb tuaj yeem hloov pauv; txheeb xyuas cov ntaub ntawv tam sim no ua ntej xaj.
Cim npe nrov: hyodeoxycholic acid hmoov, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, ntuj, zoo, Tshuag, kev muag
