Xi'an Huilin Bio-Tech Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm folic acid hmoov hauv Suav teb. Nrog kev paub dhau los, peb tau cog lus los muab cov khoom lag luam zoo nrog cov nqi sib tw. Thov koj xav tias dawb rau cov lag luam wholesale bulk ntshiab folic acid hmoov rau muag ntawm no los ntawm peb lub hoobkas.
Taw qhia
Folic Acid, tseem hu ua vitamin B9, folate, los yog pteroylglutamic acid, yog ib tug dej -soluble B-vitamin tseem ceeb rau ntau yam physiological dab nyob rau hauv tib neeg lub cev. Nws ua lub luag haujlwm tseem ceeb hauv ib qho -carbon metabolism, ua haujlwm ua coenzyme hauv kev sib txuas ntawm nucleic acids (DNA thiab RNA), amino acid metabolism, thiab hloov pauv ntawm homocysteine rau methionine.
Raws li ib tug hluavtaws, oxidized daim ntawv folate, folic acid yog ruaj khov thiab bioavailable tshaj li ib txwm tshwm sim folates zaub mov, ua rau nws nyiam daim ntawv rau kev noj haus, zaub mov fortification, thiab kev siv tshuaj. Tsis zoo li ntuj folates uas degrade nkag tau yooj yim thaum ua zaub mov thiab khaws cia, folic acid tseem nyob ruaj khov, kom ntseeg tau tias muaj kev noj qab haus huv thiab zoo ib yam thoob plaws ntau hom khoom.
Folic acid yog ib qho ntawm feem ntau kawm micronutrients nyob rau hauv pej xeem noj qab haus huv, nrog ntau xyoo ntawm kev soj ntsuam pov thawj qhia tau hais tias nws indispensable luag hauj lwm nyob rau hauv kev tiv thaiv neural tube defects (NTDs), txhawb kev tsim cov qe ntshav liab, tswj cov hlab plawv kev noj qab haus huv los ntawm homocysteine regulation, thiab pab mus rau ib txwm kev puas siab puas ntsws kev ua hauj lwm thiab kev tiv thaiv kab mob.
Cov Qauv Khoom & Specifications
| Parameter | Specification | Txoj kev |
|---|---|---|
| Assay (anhydrous hauv paus) | 97.0%–102.0% | HPLC |
| Qhov tshwm sim | Daj mus rau yellowish -txiv kab ntxwv crystalline hmoov | Pom kev |
| Kev txheeb xyuas | Zoo (IR / UV) | IR/UV |
| Cov ntsiab lus dej | 5.0%–8.5% | Karl Fischer |
| Residue ntawm Ignition | Tsawg dua lossis sib npaug li 0.2% | USP |
| Yam Khoom Muaj (Tag nrho) | Tsawg dua lossis sib npaug li 2.0% | HPLC |
| Hnyav Hlau | Tsawg dua lossis sib npaug li 10 ppm | USP |
| Particle Loj | 95% txog 80 mesh | Sieve Analysis |
Folic Acid Cov txiaj ntsig
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Kev tiv thaiv ntawm Neural Tube DefectsPericonceptional folic acid supplementation yog ib qho tseem ceeb tshaj plaws ntawm kev noj qab haus huv pej xeem cov kev pab cuam ntawm lub xyoo dhau los. USPSTF 2023 hloov kho kev tshuaj xyuas tau lees paub tias kev ntxiv cov tshuaj folic acid txo qhov kev pheej hmoo ntawm neural tube defects (NTDs) hauv cov menyuam mos. Kev tsim nyog folate nyob rau thawj 28 hnub ntawm cev xeeb tub-thaum lub raj neural kaw- yog qhov tseem ceeb, thiab kev noj tshuaj ntxiv ntawm 400–800 µg / hnub raug pom zoo rau txhua tus poj niam uas muaj hnub nyoog muaj menyuam. |
Homocysteine txo qis & Kev them nyiaj yug plawvHomocysteine Lowering Trialists' Collaboration meta- tsom xam pom koob tshuaj- nyob ntawm qhov txo qis hauv plasma homocysteine nrog kev ntxiv folic acid. Siab homocysteine yog ib qho kev pheej hmoo txaus ntshai rau cov kab mob plawv thiab cerebrovascular. Folic acid, raws li methyl pub dawb hauv homocysteine remethylation, txo qis homocysteine plasma qib, nrog 0.8 mg / hnub txo qhov concentration ntawm kwv yees li 23%. |
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Kev tsim cov qe ntshav liab & tiv thaiv ntshav qab zibFolic acid yog qhov tseem ceeb rau erythropoiesis, txheej txheem ntawm cov ntshav liab tsim. Folate deficiency ua rau megaloblastic anemia, uas tshwm sim los ntawm kev tsim cov qe ntshav liab loj loj, tsis paub qab hau uas tsis tuaj yeem thauj oxygen zoo. Ntxiv nrog rau folic acid sai kho cov folate -deficiency anemia, kho cov hematological tsis zoo thiab txhim kho cov pa oxygen thoob plaws hauv lub cev. |
DNA Synthesis & Cellular DivisionRaws li ib tug coenzyme nyob rau hauv ib tug -carbon hloov cov tshuaj tiv thaiv, folic acid yog indispensable rau lub biosynthesis ntawm purines thiab thymidylate- lub tsev blocks ntawm DNA. Qhov no ua rau folate tseem ceeb rau txhua lub cell faib sai, suav nrog cov hauv cov pob txha pob txha, plab hnyuv epithelium, thiab tsim cov ntaub so ntswg hauv plab. Cov xwm txheej txaus folate txhawb nqa cov cellular proliferation, kev loj hlob ntawm cov ntaub so ntswg, thiab kho thoob plaws hauv lub neej. |
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Folic Acid siv rau dab tsi?
- Khoom noj khoom haus- Folic acid yog cov folate uas siv dav tshaj plaws hauv multivitamin thiab ib qho - cov khoom xyaw ntxiv hauv cov ntsiav tshuaj, tshuaj ntsiav, softgel, thiab gummy hom, tsom rau kev noj qab haus huv, khoom noj khoom haus ua ntej yug menyuam, thiab kev noj qab haus huv ntawm lub plawv.
- Food Fortification- Yuav tsum muaj folic acid fortification ntawm cereal nplej thiab hmoov nplej tau siv nyob rau hauv ntau dua 80 lub teb chaws thoob ntiaj teb, suav nrog Tebchaws Meskas, Canada, thiab Australia, raws li tus nqi siab heev- cov tswv yim kev noj qab haus huv zoo rau pej xeem los txo qhov tshwm sim ntawm NTDs ntawm cov pej xeem.
- Cov vitamins ua ntej yug menyuam- Raws li tus qauv kub tsim rau kev tiv thaiv NTD, folic acid yog ib qho yuav tsum tau ua ntawm tag nrho cov txheej txheem ua ntej yug menyuam, feem ntau ntawm koob tshuaj 400–800 µg/hnub, nrog cov koob tshuaj ntau dua (4-5 mg / hnub) tau sau rau cov poj niam uas muaj kev pheej hmoo siab.
- Kev npaj tshuaj- Folic acid tau teev nyob rau hauv WHO Tus Qauv Daim Ntawv Teev Cov Tshuaj Tseem Ceeb thiab yog siv rau hauv kev kho mob rau kev kho mob megaloblastic anemia, folate deficiency, thiab ua ib qho ntxiv hauv kev kho methotrexate.
- Functional Foods & Beverages- Folic acid tau muab tso rau hauv cov khoom noj muaj zog noj tshais, khoom noj khoom haus bar, hloov pluas noj, thiab dej haus ua haujlwm los txhim kho lawv cov khoom noj khoom haus thiab txhawb nqa cov lus pom zoo noj folate txhua hnub.
- Tsiaj Noj- Folic acid tau ntxiv rau cov tsiaj pub tsiaj thiab cov khoom noj tsiaj los txhawb kev loj hlob, kev loj hlob, thiab kev noj qab haus huv tag nrho hauv cov tsiaj txhu, nqaij qaib, thiab cov tsiaj ua ke.
Cov lus nug nquag nug (FAQ)
Q: Dab tsi yog qhov txawv ntawm folic acid thiab cov khoom noj ntuj folate?
Folic acid yog tag nrho oxidized, hluavtaws monoglutamate daim ntawv folate uas ruaj khov dua thaum ua thiab cia. Cov zaub mov ntuj folates txo cov polyglutamate cov ntaub ntawv uas tsis ruaj khov thiab muaj kwv yees li 50% bioavailability. Folic acid, piv txwv li, muaj ze li ntawm 100% bioavailability thaum noj ntawm lub plab khoob thiab 85% thaum noj nrog zaub mov, ua kom nws muaj txiaj ntsig zoo ntawm kev nce ntshav folate.
Q: Dab tsi yog qhov pom zoo noj folic acid txhua hnub?
Qhov pom zoo pub noj haus (RDA) rau cov neeg laus yog 400 µg DFE / hnub (Dietary Folate Equivalents). Rau cov poj niam uas muaj hnub nyoog yug me nyuam, 400-800 µg / hnub raug pom zoo rau kev tiv thaiv NTD. Thaum cev xeeb tub, RDA nce mus rau 600 µg DFE / hnub, thiab thaum cev xeeb tub mus txog 500 µg DFE / hnub. Cov koob tshuaj ntau npaum li 5 mg / hnub yog siv nyob rau hauv kev saib xyuas kev kho mob rau cov kev qhia tshwj xeeb.
Q: Vim li cas folic acid nyiam tshaj 5-MTHF rau zaub mov fortification?
Folic acid yog qhov zoo dua rau qhov loj- cov khoom noj khoom noj muaj zog vim nws qhov kev ruaj ntseg zoo dua, zoo - tus yam ntxwv ntawm kev nyab xeeb profile, thiab cov ntaub ntawv pov thawj kev kho mob dav dav nyob rau ntau xyoo lawm. Nws tseem nyob ruaj khov nyob rau hauv ntau qhov kub thiab txias, av noo, thiab pH, thiab tau ua kom pom qhov ua tau zoo hauv kev txo qis NTD tshwm sim los ntawm 25-50% hauv cov tebchaws uas yuav tsum tau muaj kev tiv thaiv kev tiv thaiv.
Q: Puas yog folic acid muaj kev nyab xeeb rau kev siv sijhawm ntev -?
Yog lawm. Folic acid muaj cov ntaub ntawv kev nyab xeeb dav dav uas txhawb nqa los ntawm ntau xyoo ntawm kev siv tshuaj kho mob thiab cov pej xeem- cov kev pab cuam tiv thaiv qib. Qhov siab siab siab siab (UL) rau cov neeg laus yog 1,000 µg / hnub los ntawm cov khoom siv ntxiv. Qhov kev txhawj xeeb tseem ceeb ntawm kev nyab xeeb yog qhov siab - koob tshuaj folic acid tuaj yeem npog cov tsos mob hematological ntawm vitamin B12 tsis txaus, muaj peev xwm ncua kev kuaj mob ntawm B12 tsis txaus- cuam tshuam txog kev puas hlwb. Qhov kev txhawj xeeb no tau txo qis los ntawm kev saib xyuas B12 cov xwm txheej hauv - cov neeg muaj kev pheej hmoo.
Q: Yuav khaws cov hmoov folic acid li cas?
Khaws rau hauv lub thawv kaw nruj nreem ntawm 15-25 degree, tiv thaiv los ntawm lub teeb thiab noo noo. Folic acid yog rhiab heev rau lub teeb ultraviolet, uas tuaj yeem ua rau photodegradation. Raws li kev pom zoo khaws cia, cov khoom lag luam muaj lub neej txee ntawm 36 lub hlis. Tsis txhob raug rau cov oxidizing muaj zog thiab huab cua pH.
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Rau kev nug, hais lus, lossis cov qauv thov, thov hu rau:sales@huilinbio-tech.com
Cov ntaub ntawv
- Teb Chaws Asmeskas Tiv Thaiv Kev Pabcuam Task Force. Folic Acid Supplementation to Prevent Neural Tube Defects: Hloov Cov Ntaub Ntawv Qhia Txog Kev Tshawb Fawb thiab Kev Tshawb Fawb.JAMA. 2023;330(5):454–459. PIB: 37526714
- De-Regil LM, et al. Cov teebmeem thiab kev nyab xeeb ntawm periconceptional qhov ncauj folate supplementation rau kev tiv thaiv kev yug menyuam.Cochrane Database Syst Rev.2015;(12): CD007950.PIB: 26662928
- Homocysteine Lowering Trialists Kev Sib Koom Tes. koob tshuaj -nyob ntawm cov teebmeem ntawm folic acid ntawm cov ntshav siab ntawm homocysteine : ib qho meta- kev tshuaj xyuas ntawm qhov kev sim randomized.Am J Clin Nutr. 2005;82(4):806–812. PIB: 16210710
- Ohrvik VE, Witthoft CM. Tib neeg folate bioavailability.Khoom noj khoom haus. 2011;3(4):475–490. PIB: 22254106
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