Khoom taw qhia:
Betulinic acid hmoovyog lub ntuj lupane pentacyclic triterpene compound. Lub npe tshuaj yog {{0}}hydroxyl-lup-20 (29)-ene-28-OIC acid, molecular mis C30H48O3, molecular hnyav 456.71, CAS naj npawb 472-15-1, boiling point 550.0 ± 33.0 degree (Predicted), thiab acidity coefficient (PKA) 4.61. Betulinic acid hmoov yog muab rho tawm los ntawm cov tawv ntoo ntawm birch. Nws yog ntuj luminescent pentacyclic triterpenoid compound. Nws muaj ntau yam ntxwv lom. Nws muaj lub luag haujlwm ntawm kev tiv thaiv kab mob, tiv thaiv kab mob, tiv thaiv kab mob thiab tiv thaiv kev laus, thiab muaj kev ua haujlwm siab, tsis muaj tshuaj lom thiab muaj kev phiv ntau.
Qhov chaw thiab kev yuav khoom:
Ntuj betulinic acid feem ntau yog muab rho tawm los ntawm cov tawv ntoo ntawm Betula platyphylla, thiab tseem muaj nyob rau hauv ntau cov nroj tsuag, xws li Peach Tree, Ziziphus Spinosae Noob, Jujube, Platanus acerifolia, Zizyphus spinosa, Prunella vulgaris thiab hais txog.
Muaj ntau txoj hauv kev xws li cog extraction, tshuaj synthesis thiab biotransformation.
1. Cog rho tawm txoj kev
Cov txheej txheem rho tawm ib txwm siv ethanol, ethyl acetate thiab methanol ua cov kuab tshuaj extraction, thiab siv txoj kev immersion, Soxhlet extraction method, cua kub reflux extraction method thiab ultrasonic extraction method. Nyob rau hauv xyoo tas los no, txoj kev tshiab xws li supercritical kua extraction, microwave-pab extraction thiab solid-kua extraction kuj tau tsim. Txawm li cas los xij, vim muaj cov ntsiab lus qis ntawm betulinic acid hauv cov nroj tsuag, txoj kev no muaj teeb meem ntawm kev siv cov khoom siv loj, ntau impurities thiab qis tawm los.
2. Cov txheej txheem tshuaj synthesis
Ib-kauj ruam synthesis method
Kev rho tawm ntawm betulin thiab kev npaj ntawm BA yog ua tiav ib txhij. Cov nroj tsuag tau leached nrog cov kuab tshuaj organic xws li dichloromethane, chloroform, acetone, tetrahydrofuran thiab DMF kom rho tawm betulin nrog cov ntsiab lus siab. Nyob rau tib lub sijhawm, oxidants xws li zinc nitrate thiab chromium nitrate yog txuas rau cov khoom thauj khoom xws li silica gel, alumina thiab jiaolingshi, thiab cov extracted betulin yog oxidized kom tau BA. Cov qauv no tsis yog xaiv, cov xwm txheej nyuaj rau kev tswj hwm, cov txiaj ntsig qis thiab cov kauj ruam purification tseem xav tau.
Txoj kev semi-synthesis
Semi-synthetic txoj kev yog rho tawm betulin los ntawm cov nroj tsuag ua ntej, thiab ces ua BA los ntawm betulin los ntawm ib tug series ntawm tshuaj tiv thaiv. Vim hais tias cov ntsiab lus ntawm betulin nyob rau hauv cov nroj tsuag yog qhov siab, nws tuaj yeem tau txais los ntawm kev rho tawm ncaj qha thiab tus nqi qis, yog li cov txheej txheem semi-synthesis tuaj yeem txo tus nqi. Kev sim qhia tias betulin tuaj yeem xaiv oxidized rau betulinic acid nrog cov txiaj ntsig ntawm 93-98% nyob rau hauv catalysis ntawm Cr(VI) compound hauv acetone (15-25 degree) tov nrog alumina raws li cov cab kuj, thiab ntawm tib lub sij hawm, lub alumina cab kuj tuaj yeem adsorb thiab tshem tawm cov tshuaj lom.
3. Txoj kev Biotransformation
Kev hloov kho cov txheej txheem ntawm cov substrate los ntawm cov kab mob los yog cov enzymes tsim thaum lub sij hawm metabolism; Piv nrog rau cov tshuaj synthesis, biotransformation muaj qhov zoo ntawm ntsuab tsis muaj kuab paug, mob me me, ntau stereoselectivity thiab regional selectivity. Nws tau pom tias cov metabolic txaus tshuav ntawm fatty acid thiab terpenoid precursor synthesis txoj hauv kev tau muaj txiaj ntsig zoo rau BA synthesis, thiab kev tsim cov BA tau nce ntau ntxiv los ntawm kev sib koom ua ke ntawm cov noob tswj tseem ceeb (HFA1, HMG1 thiab ERG 9) hauv cov no. ob txoj kev metabolic. Cov kab ke engineering tuaj yeem tsim cov mg-theem BA ib liter ntawm kab lis kev cai nruab nrab, thiab kev npaj thiab kev sib txuas ntawm BA tau nce mus rau qhov siab tshiab.
Cov yam ntxwv ntawm betulinic acid hmoov:
Cov khoom xyaw ntuj: betulinic acid hmoov yog muab rho tawm los ntawm birch bark, thiab tsis muaj tshuaj additives los yog hluavtaws cov khoom xyaw. Nws yog cov nroj tsuag ntuj extract, uas ua raws li cov neeg niaj hnub nrhiav cov khoom ntuj thiab ntsuab.
Antibacterial inhibition: Betulinic acid hmoov muaj cov tshuaj tua kab mob zoo thiab inhibitory teebmeem. Nws tuaj yeem cuam tshuam kev loj hlob ntawm cov kab mob, cov kab mob thiab lwm yam kab mob thiab pab kom muaj kev huv thiab huv.
Kev tu thiab tshem tawm muaj peev xwm: Betulinic acid hmoov muaj peev xwm ntxuav thiab tshem tawm cov kab mob, uas tuaj yeem tshem cov roj stains thiab lwm yam av. Nws tuaj yeem maj mam tshem tawm cov av thaum lub sijhawm tu thiab tiv thaiv qhov chaw ntawm cov khoom ntxuav tib lub sijhawm.
Adsorption ntawm tsw: Betulinic acid hmoov muaj peev xwm adsorption zoo, uas tuaj yeem pab tshem tawm tsw. Nws tuaj yeem nqus cov ntxhiab tsw molecules hauv huab cua thiab ua rau huab cua tshiab.
Kev tiv thaiv ib puag ncig thiab kev noj qab haus huv: Raws li betulinic acid hmoov yog lub ntuj extract, nws tsis muaj tshuaj lom thiab tsis muaj tshuaj lom thiab tsis muaj mob rau tib neeg lub cev thiab ib puag ncig. Kev siv betulinic acid hmoov rau kev tu thiab tu neeg mob tuaj yeem txo qhov cuam tshuam rau ib puag ncig thiab tiv thaiv tib neeg kev noj qab haus huv zoo dua.
Kev siv ntau yam: Betulinic acid hmoov tuaj yeem siv dav hauv ntau qhov chaw, suav nrog kev tu tsev, tu tus kheej, kev zoo nkauj thiab lwm yam. Nws tuaj yeem siv los ntxuav chav ua noj, chav dej, khaub ncaws, thiab lwm yam, thiab tseem tuaj yeem siv los ua ib feem ntawm cov khoom xws li lub qhov ncauj qhov ntswg thiab cov gels da dej.
Betulinic acid hmoov puas tuaj yeem tiv thaiv kev laus?
Betulinic acid hmoov tuaj yeem pab tiv thaiv kev laus rau qee yam. Betulinic acid nws tus kheej muaj cov tshuaj tua kab mob antioxidant thiab tiv thaiv kab mob, uas pab ua kom cov txheej txheem laus ntawm daim tawv nqaij. Antioxidant muaj peev xwm tuaj yeem pab tshem tawm cov dawb radicals thiab txo kev puas tsuaj rau ntawm daim tawv nqaij, thaum cov khoom siv tshuaj tiv thaiv tuaj yeem pab txo cov tawv nqaij o thiab rhiab heev thiab txhawb kev noj qab haus huv ntawm daim tawv nqaij.
Tsis tas li ntawd, betulinic acid hmoov tuaj yeem siv los ua cov nroj tsuag ntuj hauv cov khoom tu tus kheej thiab cov khoom zoo nkauj. Kev siv cov hmoov betulinic acid hauv cov khoom tu lub ntsej muag tuaj yeem ua rau muaj qee qhov kev tiv thaiv kev laus, xws li pab txo qis wrinkles thiab txhim kho cov xim ntawm daim tawv nqaij.
Daim ntawv thov ntawm betulinic acid hmoov:
Kev tu tsev hauv tsev:Betulinic acid hmoovtuaj yeem siv los ntxuav cov khoom siv hauv tsev thiab qhov chaw, xws li chav ua noj countertops, pem teb, iav thiab lwm yam. Koj tuaj yeem sib tov cov hmoov betulinic acid kom zoo nrog dej kom muab tshuaj txhuam, tom qab ntawd txhuam nws nrog daim ntaub los yog daim txhuam cev thiab maj mam so qhov chaw kom huv.
Kev saib xyuas tus kheej: Betulinic acid hmoov tuaj yeem muab ntxiv rau cov khoom tu tus kheej xws li da dej gel, tshuaj zawv plaub hau thiab lub ntsej muag lub ntsej muag, uas muaj lub luag haujlwm ntawm kev ntxuav, tshuaj tua kab mob thiab tsw ntxhiab. Tus nqi tsim nyog ntawm betulinic acid hmoov tuaj yeem muab ntxiv rau cov khoom raws li xav tau, thiab tom qab ntawd siv raws li kev siv ib txwm siv.
Kev zoo nkauj thiab kev tu tawv nqaij: betulinic acid hmoov tuaj yeem siv los ua daim npog ntsej muag lossis lub ntsej muag ntxuav. Betulinic acid hmoov tuaj yeem sib xyaw nrog cov kua dej uas tsim nyog (xws li dej, dej paj lossis roj hauv paus) kom muab tshuaj txhuam, tom qab ntawd siv rau lub ntsej muag, maj mam zaws thiab ntxuav nrog dej sov.
Slimming: Betulinic acid hmoov kuj siv tau rau hauv cov khoom slimming. Nws muaj peev xwm ntawm kev ntxuav thiab decontamination, uas tuaj yeem pab ntxuav cov tawv nqaij, txhawb cov ntshav ncig thiab txhim kho daim tawv nqaij zoo nkauj.
Kev ua haujlwm ntawm betulinic acid hmoov:
Antibacterial thiab anti-inflammatory: Betulinic acid hmoov muaj cov tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob, uas tuaj yeem cuam tshuam kev loj hlob ntawm cov kab mob thiab cov fungi thiab txo cov tawv nqaij mob. Qhov no ua rau nws muaj txiaj ntsig zoo rau kev kho mob ntawm daim tawv nqaij xws li pob txuv thiab eczema.
Antioxidant: Betulinic acid hmoov muaj cov nyhuv antioxidant, uas tuaj yeem tshem tawm cov dawb radicals thiab txo cov oxidative puas rau ntawm daim tawv nqaij. Qhov no yuav pab ncua kev laus ntawm daim tawv nqaij thiab txo cov tsos ntawm cov kab zoo thiab wrinkles.
Kev ntxuav thiab adsorption: betulinic acid hmoov tuaj yeem nqus cov roj ntau dhau thiab cov impurities, ntxuav daim tawv nqaij pores thiab txo qhov tsim ntawm blackheads thiab pob txuv. Nws tseem tuaj yeem nqus cov tshuaj tsw qab thiab ua kom tawv nqaij tshiab.
Moisturizing thiab moisturizing: Betulinic acid hmoov muaj kev ua haujlwm zoo moisturizing, uas tuaj yeem ua kom cov dej noo ntawm daim tawv nqaij thiab txhim kho softness thiab smoothness ntawm daim tawv nqaij. Nws tuaj yeem tsim cov yeeb yaj kiab tiv thaiv, txo cov dej poob thiab muab cov nyhuv moisturizing ntev.
Txawm tias tawv nqaij tawv: Betulinic acid hmoov pab kom cov tawv nqaij tawv thiab txo qhov pom ntawm pob thiab freckles. Nws tuaj yeem inhibit qhov tsim ntawm melanin, ua kom tawv nqaij tawv thiab ua kom tawv nqaij ci dua thiab zoo ib yam.
Yuav tiv tauj peb li cas?
Peb lub tuam txhab yog ib tus kws tshaj lij ntawm cov khoom siv ua tiav, suav nrog cov khoom cog, txiv hmab txiv ntoo thiab zaub hmoov, tshuaj pleev ib ce, ntsiav tshuaj thiab khoom qab zib. Peb cov khoom raug muab ncaj qha los ntawm cov tuam ntxhab, yog li tus nqi zoo heev thiab qhov zoo yog lav. Koj tuaj yeem yuav nrog kev ntseeg siab. Tam sim no peb lub tuam txhab muag khoom zooBetulinic acid hmoov. Yog tias koj txaus siab rau cov khoom no thiab xav paub txog nws, koj tuaj yeem sab laj nrog peb tus thawj tswj hwm tus account los ntawm thoob ntiaj teb lub vev xaib lossis email. Peb qhov chaw nyob e-mail yogella.zhang@huilinbio-tech.com ib.