Dab tsi yog Bergenin hmoov? Cov txiaj ntsig & Cov Kev Siv

Bergenin yog lub ntuj sib xyaw pom nyob rau hauv cov nroj tsuag li bergenia Hmoov .

1. Dab tsi yog Bergenin hmoov?

• Tau qhov twg los:Feem cais los ntawm:

Rhizomes ntawmBergenia Purpurascens(Cov ntxhw pob ntseg, 岩白菜 -Yan bai caiHauv TCM)

Tawv ntoo ntawmMallotus Philipsis(Kamala ntoo)

Keeb kwm ntawmArdisia Japonica(Marlberry)

• Kev Siv Tsoos:

Ayurveda: Kev tiv thaiv daim siab, qhov txhab zoo

TCM: Relieves hnoos, txo cov hnoos qeev, kho mob ntsws^[1]

• Tus Kheej Yog Tus: A C-Glycoside ntawm 4- o-methyl gallic acid (C₁₄H₁₆O₉).

{{02.} Cov khoom tseem ceeb & specifications

3.} Cov ntaub ntawv pov thawj raws li cov nyiaj tau los & kev sib cav

Lub tswv yim ntawm dual cox -1 / 2 thiab 5- lex inhibition^[9]

✅ Muaj Peev Xwm Tiv Thaiv Tiv Thaiv & Analgesic

• Mechanism:

Sivl inhibition ntawmCox -2(prostaglandins) thiab5- lex(leukottrienes)^[2]→ Txo cov ntsiab lus sib kho mob inkiat .

TxhawbNf-κbthiabTnf- / il -6Kos npe .

• Daim Ntawv Thov:Kev mob caj dab, cov tshuaj tsw qab ntawm cov kua nplaum, IBD txhawb .

✅ Antitionsusive (hnoos suppressant)

• Mechanism:

Central Action ntawm lubMOB ZUS CENTER CENTER(opioid receptor-independent txoj kev)^[3].

Kev txo pob taws rau ntawm cov pa dej .

• Tib neeg cov pov thawj:Clinically tau zoo hauv mob ntsws (piv rau codeine, tsis muaj quav)^[4].

✅ HepatoproTsite (Liiver Shield)

• Mechanism:

Ua kom tiavNpf2 txoj kev→ Upregulates antioxidant enzymes (sod, glutathione)^[5].

InhibitsCyp2e1(txo cov metabolite tsim) {.

Txo cov hepatic fibrosis los ntawm kev tsujTgf - 1 / smadkos npe^[6].

• Kev ua tau zoo:Tiv thaiv cov tshuaj / taug kev ua yeeb ncuab (paracetamol, CCC₄, ethanol) {{1} {1}.

✅ Antioxidant & Antidiabetic

• Mechanism:

Direct Dawb Radical Tsho (• Oh, Dpph) .

↑ Insulin rhiabVia Ampk / Pppar Kev Ua Haujlwm^[7]→ Kev ntshav qab zib & lipids .

✅ Senal (Raum) Tiv Thaiv

• Kev nthuav tawm lub luag haujlwm: Zos Cov Ntshav Qab Zib Mephopathy los ntawm kev txo oxidative kev ntxhov siab & fibrosis^[8].

4.} Daim Ntawv Thov Phiaj Xwm

5. Kev Nyab Xeeb, Dosing & Ntsiab Lus

 Kev Nyab Xeeb Profile:

• Feem ntau zoo-zam: LD₅₀ >2000 mg / kg (kev kawm txog) → qes acute toxicity^[1].
• Tsis paub tias muaj xom:Tsis-GMO, gluten-dawb (paub meej ntawm COA) .
• Kev sib cuam tshuam yeeb tshuaj:Theoretical kev sib cuam tshuam nrog cyp2e1- metabolized tshuaj (e}} g}, permorzoxone) {{4}

 Cov koob tshuaj raug (cov neeg laus - Bergenin 95% extract):

• Hnoos supress:100-300 mg / hnub
• Daim siab txhawb nqa:200-400 mg / hnub
• Pob txha o:250-500 mg / hnub
• Topal (tawv nqaij):{{0 {}}% hauv qab zib / gel

 Contraindications & Ceev Faj:

• Cev xeeb tub / pub niam mis:Zam (cov ntaub ntawv kev nyab xeeb tsis txaus) .
• Bilialy Thaiv:Contraindicated (tej zaum yuav txhawb bile Flow) .
• Kev phais:Tsum tsis ua haujlwm 2 lub lis piam ua ntej / tshaj tawm (tsawg tsawg cov ntaub ntawv) .

6.} Extract Specifications: Sib Xws Li Kev Purity Los Thov

{{0 {}} Vim li cas Bergenin sawv tawm?

1. Multi-Air Kev Tiv Thaiv:Cov tshuaj tiv thaiv kev cuam tshuam ntawm daim siab, lub ntsws, raum & pob qij txha .
2. Cov Tshuaj Uas Tsis Muaj Quav:Kev nyab xeeb hloov rau opioid-based antitussives .
3. Dual anti-inflammatory kev txiav txim siab:Thaiv ob qho tib si cox -2 & {5- lix txoj kev - tsis tshua muaj nyob hauv ntuj sib xyaw.
4. Crystalline Purity: Easily standardized to >98%, ua kom tiav batch li .

Tau qhov twg los-qib Bergenin Hmoov:
Peb muabBergenin muaju(98% HPLC)

Bergenin 50%, 90%, 98% +

Nruj me ntsis kuaj:Cov hlau hnyav, tshuaj tua kab, cov microbes, cov kuab tshuaj uas muaj nyob hauv

ISO 9001 muaj ntawv lees paub tsim

Qhov zoo tagnrho rau:
• Ntuj hnoos & ua pa ua pa • Cov tshuaj tiv thaiv hepatoprotrotive • anti-inflammatory collections • Cov kev noj qab haus huv metabolic

[Tiv tauj peb rau cov qauv & nqi nqi](Txuas rauNplooj ntawv Nplooj ntawv/Kev noog)

References & Cited:

1. Suav Lub Pharmacoploeia Commissional . (2020). Pharmacopoeia ntawm cov neeg lub koom pheej ntawm Tuam Tshoj. vol Kuv .(Monogr rau Bergenin & Bergeniae Herba).
2. Lim, h {., thiab al. (2000)."Anti-inflammatory kev ua ntawm bergenin ntawm inhibition ntawm inhibition ntawm NF-κB thiab CoX-2".CARRA MENERA, 66 (05), 469 - {471. [-2000-8595}}}}}}}}} κb inhibition) *.
3. Nosalova, g {., thiab al. (2011) {3} {3}"Antitionsusive kev ua ntawm glucopyranoside bergenin" .Hnoos, 7 (1), {1.} [doi: 10.1186 / 1745-9974-7-1](Mechanism ntawm hnoos supress).
4. Maiti, {., thiab al. (2019)."Bergenin: ib qho kev cog lus tawm tsam nrog cov pov thawj kuaj mob" .Phau ntawv Journal ntawm Ethnoopharmacology, 245, {112153.} [doi: 10 {}}} 1016 / j. {}}](Chaw kho mob vs . tsov rog mob ntsws).
5. Pradeep, h {. ., thiab al {2} {{4 {4}"Bergenin accordates NRF2 signaling los tiv thaiv hepg2 hlwb tiv thaiv oxidative kev nyuaj siab thiab mitochondrial kawg".Chemico-biological cuam tshuam, 281, 129 - {{138.} [} [{}}} 1016 / J.CBI.2017.12.034](NRF2 Kev Tiv Thaiv & Daim Siab Tiv Thaiv).
6. Li, c ., thiab al . (2020)."Bergenin attenele hepatic fibrosis los ntawm inhibiting tgf {{0 {.Thoob Ntiaj Teb Kev Nyab Xeeb Kev Ntseeg, 82, {{106349. [doi: 10 {}} 1016 / j.intom {}}](Anti-fibrotic tshuab).
7. Zhang, y {{{., thiab al. (2021) {3} {3}"Bergenin txhim kho cov insulin rhiab ntawm kev ua kom ampk hauv cov pob txha pob txha pob txha pob txha" .Phau Ntawv European ntawm Pharmacology, 892, {173749.} [} [}}}}}} 1016 / j.ejphar {{4 4}}](Ampk / PPPPION ua rau cov piam thaj haus).
8. Guo, x {., thiab al . (2022) ."Bergenin Amelior Daj mob Ntshav Qab Zib Mephotraty los ntawm kev thuam Oxidating Oxidative Oxidating Oxid2 / ho} {.Phytomedicine, 99, {{154007. [doi: 10 {}} 1016 / j.phymed {{}}]Kev tiv thaiv (raum tiv thaiv ntshav qab zib).
9. Mithun rudrapal, thiab al . (2023) ."Dual syneroistic Inhibition ntawm Cox thiab LEX los ntawm cov txuj ci tsim los ntawm cov txuj ci tseem ceeb txhua hnub, Tshooj Lus Qhia:8656 (2023)