Taw qhia
Vitamin K2hais txog ib pawg ntawm cov tshuaj hu ua menaquinones (MKs), uas txawv ntawm qhov ntev ntawm lawv cov saw hlau sab. Daim ntawv tshawb fawb tshaj plaws thiab muaj ntau tshaj plaws yogMenaquinone-7 (MK-7). Tsis zoo li cov saw luv luv menaquinones, MK-7 muaj cov saw ntev ntev (xya isoprene units), uas muab nws ib nrab-lub neej txog li 3 hnub hauv cov hlab ntsha. Qhov no txhais tau hais tias ib koob tshuaj ib hnub yog txaus los tswj hwm cov vitamin K2 kev ua haujlwm txhua hnub[1].
Xav txog vitamin K2 (MK-7) raws li koj lub cev"calcium traffic controller."Koj lub cev xav tau calcium los tsim cov pob txha muaj zog, tab sis calcium uas xaus rau hauv qhov chaw tsis ncaj ncees lawm - xws li cov phab ntsa hauv cov hlab ntsha - tuaj yeem ua rau muaj kev phom sij. MK-7 ua kom muaj ob lub ntsiab lus tseem ceeb uas ua haujlwm ua ke: ib qho uas rub cov calcium rau hauv koj cov pob txha (osteocalcin) thiab lwm yam uas thaiv calcium los ntawm kev tso rau hauv koj cov hlab ntsha (matrix Gla protein, lossis MGP)[2].
MK-7 yog tsim los ntawm cov kab mob fermentation ntuj sivBacillus subtilis- tib yam kab mob uas siv los ua natto, ib txwm Japanese fermented soybean tais ib txwm nplua nuj nyob rau hauv vitamin K2. Cov txheej txheem fermentation no yields lub biologically activetag nrho-transconfiguration, uas yog tib daim ntawv pov thawj ua tau zoo qhib lub carboxylase enzyme uas hloov ntawm osteocalcin thiab MGP. Vitamin K2 (MK-7) tau lees paub tus kheej GRAS xwm txheej hauv Tebchaws Meskas, tau txais kev pom zoo Novel Food los ntawm European Food Safety Authority (EFSA), thiab tam sim no tau tso cai ua cov khoom noj khoom haus muaj zog hauv Suav teb raws li GB 1903.81-2025.
Physicochemical Properties & Specifications
| Khoom | Tus nqi |
|---|---|
| CAS Nr .: MK-7 | 2124-57-4 |
| Molecular Formula | C₄₆H₆₄O₂ |
| Molecular Luj | 648.99 - 649.02 g / mol |
| Qhov tshwm sim | Pleev daj kom tawm -dawb mus rau daj crystalline hmoov |
| tsw / Saj | Yuav luag odorless, tasteless |
| Melting Point | 112-115℃(decomposes) |
| Solubility hauv dej | Insoluble |
| Solubility hauv Organic Solvents | Soluble hauv ethanol, methanol, acetone, chloroform, diethyl ether, DMSO; soluble nyob rau hauv zaub roj |
| Isomeric Configuration | All-trans (biologically active nkaus xwb; cis-isomers tsis paub ua haujlwm) |
| Tag nrho-Trans MK-7 Purity | Ntau dua lossis sib npaug li 97% (qib siab purity) |
| Assay Purity | 98.0-102.0% (USP specifications) |
| Poob rau ziab | Tsawg dua lossis sib npaug li 5.0% |
| Total Tshauv | Tsawg dua lossis sib npaug li 0.1% |
| Hnyav Hlau | Tsawg dua lossis sib npaug li 10 ppm |
| Lead (Pb) | Tsawg dua los yog sib npaug li 0.5 ppm |
| Arsenic (As) | Tsawg dua lossis sib npaug li 1 ppm |
| Mercury (Hg) | Tsawg dua lossis sib npaug li 0.1 ppm |
| Cadmium (Cd) | Tsawg dua lossis sib npaug li 1 ppm |
| Tag nrho Aerobic Microbial suav | Tsawg dua lossis sib npaug li 1000 cfu / g |
| Poov & Pwm suav | Tsawg dua lossis sib npaug li 100 cfu / g |
| E. coli | Negative hauv 1g |
| Salmonella | Negative hauv 25g |
| Cia Kub | 2-8℃(tub yees) |
| Kev cia khoom | Lub thawv kaw zoo kom deb ntawm noo noo, lub teeb, thiab oxygen; tiv thaiv los ntawm tshav kub |
| Txee lub neej | 24-48 lub hlis (nyob ntawm kev tsim thiab ntim) |
| GHS Hazard Classification | Tsis raug cais raws li kev phom sij ntawm qhov qis qis (<1%); standard laboratory precautions for concentrated form |
Mechanism ntawm Action
Vitamin K2 (MK-7) ua raws li qhov tseem ceebpab (cofactor)rau ib qho enzyme hu ua gamma-glutamyl carboxylase. Qhov enzyme no "hloov rau" ob lub calcium uas tuav cov proteins uas tseem ceeb rau cov pob txha thiab lub plawv noj qab haus huv [1][2].
Kauj Ruam 1: Ua kom cov Proteins
Yog tias tsis muaj vitamin K2 txaus, ob qho tseem ceeb ntawm cov protein tseem nyob hauv lawv cov ntaub ntawv tsis muaj zog (undercarboxylated):
- Osteocalcin (OC)- cov protein ua lub luag haujlwm rau kev coj cov calcium rau hauv koj cov pob txha matrix.
- Matrix Gla Protein (MGP)- cov protein uas tiv thaiv koj cov hlab ntsha los ntawm kev thaiv cov calcium deposits.
Thaum koj noj MK-7, nws pab cov carboxylase enzyme ntxiv ib pawg carboxyl (–COOH) rau cov proteins, hloov lawv mus rau hauv lawv.cov ntaub ntawv nquag(carboxylated osteocalcin thiab carboxylated MGP)[2].
Kauj ruam 2: Calcium mus qhov twg nws koom - rau hauv pob txha
Active osteocalcin ua zoo li acalcium hlau nplaum. Nws khi rau calcium circulating hauv koj cov ntshav thiab rub nws mus rau hauv cov pob txha matrix, ua rau koj cov pob txha denser, muaj zog dua, thiab tiv taus ntau dua. MK-7 kuj txhawb nqa osteoprotegerin, ib qho protein uas thaiv RANKL - ib qho molecule uas yuav ua rau cov pob txha tawg. Los ntawm inhibiting RANKL, MK-7 pab txo cov pob txha[1].
Kauj Ruam 3: Calcium raug thaiv los ntawm kev nkag mus rau cov hlab ntsha
Active MGP yog ib qho ntawm koj lub cev muaj zog tshaj plaws tiv thaiv tiv thaivvascular calcification- txhim kho calcium crystals hauv cov hlab ntsha phab ntsa. MGP khi rau calcium crystals thiab tiv thaiv lawv los ntawm kev nyob rau hauv cov hlab ntsha, ua kom koj cov hlab ntsha hloov tau thiab koj lub plawv noj qab haus huv.[2].
Cov txiaj ntsig ntxiv: txo qhov mob thiab tiv thaiv cov hlab ntsha
Tshaj li kev tswj hwm calcium, MK-7 kuj pab:
Txo qhov mob- Nws txo qis kev tsim cov kab mob pro-inflammatory xws li IL-1, IL-1, thiab TNF-, uas cuam tshuam rau ntau yam kab mob ntev.[1].
Tiv thaiv cov paj hlwb- Vim tias MK-7 yog cov rog-soluble, nws tuaj yeem hla cov hlab ntsha hauv hlwb thiab tuaj yeem pab tiv thaiv cov paj hlwb. Cov kev tshawb fawb soj ntsuam tau pom tias MK-7 supplementation tuaj yeem txhim kho cov tsos mob ntawm peripheral neuropathy[1].
Nyob rau hauv ib tug nutshell:
| Kev ua | Nws tshwm sim qhov twg | MK-7 Ua li cas |
|---|---|---|
| Activates osteocalcin | Cov pob txha | Rub cov calcium rau hauv cov pob txha matrix → cov pob txha muaj zog |
| Activates MGP | Cov hlab ntsha | Blocks calcium los ntawm depositing nyob rau hauv cov hlab ntsha phab ntsa |
| Txo qhov mob | Lub cev tag nrho | Lowers teeb meem inflammatory signals |
| Tiv thaiv cov hlab ntsha | Lub paj hlwb | Tej zaum yuav txhim kho cov paj hlwb thiab txo cov tsos mob neuropathy |
Yog li thaum koj noj cov vitamin K2 li MK-7, koj muab koj lub cev qhov tseem ceeb uas nws xav tautsim cov pob txha muaj zogthiabtiv thaiv koj lub siab- ob lub luag haujlwm tseem ceeb uas ua haujlwm ua ke kom koj noj qab nyob zoo thaum koj muaj hnub nyoog.
Cov txiaj ntsig kev noj qab haus huv
1 Txhim kho cov pob txha thiab txo qhov pheej hmoo ntawm pob txha
MK-7 activates osteocalcin, uas khi calcium rau hauv koj cov pob txha matrix, txhim kho pob txha zoo thiab microstructure - tsis yog pob txha ntom. Kev tshawb fawb qhia tau hais tias MK-7 supplementation txo qhov kev pheej hmoo ntawm pob txha pob txha, nrog rau cov txiaj ntsig zoo tshaj plaws pom hauv cov neeg uas pib nrog cov vitamin K tsawg.[1][3].
2 Tiv thaiv koj cov hlab ntsha thiab txhawb lub plawv noj qab haus huv
MK-7 activates matrix Gla protein (MGP), koj lub cev lub zog tshaj ntuj inhibitor ntawm artery calcification. Ib xyoo 2025 kev sim tshuaj (VitaK-CAC) tau pom tias ob xyoos ntawm MK-7 supplementation ua rau muaj kev cuam tshuam loj ntawm cov hlab ntsha hauv cov hlab ntsha hauv cov neeg mob uas muaj kab mob me me mus rau nruab nrab. [3].
3 Ua haujlwm ua ke nrog vitamin D3 thiab calcium
Xav txog cov vitamin D3 li covtsheb thauj khoomuas khaws calcium los ntawm koj cov zaub mov thiab xa mus rau hauv koj cov hlab ntsha. Vitamin K2 (MK-7) yog covtus tswj tshebuas coj calcium rau hauv koj cov pob txha thiab ua kom nws tawm ntawm koj cov hlab ntsha. Kev noj cov vitamin D3 yam tsis muaj K2 txaus tuaj yeem ua rau muaj kev pheej hmoo ntawm calcium tso rau hauv qhov chaw tsis raug. Rau cov pob txha thiab lub plawv siab tshaj plaws, MK-7 yuav tsum tau noj nrog D3 thiab calcium.
4 Txo qhov mob ntev
MK-7 pab txo qis ntawm pro-inflammatory molecules xws li IL-1, IL-1, thiab TNF-. Los ntawm kev tswj kev mob o, MK-7 txhawb nqa koj lub cev tiv thaiv kab mob thiab tuaj yeem pab txo qis kev pheej hmoo ntawm cov kab mob inflammatory[1].
5 Txhawb Nerve Health
Vim tias MK-7 yog fat-soluble, nws tuaj yeem hla cov hlab ntsha hauv hlwb. Cov kev tshawb fawb tshiab qhia tias MK-7 tuaj yeem pab tiv thaiv cov paj hlwb thiab txhim kho cov tsos mob ntawm peripheral neuropathy - ib qho mob uas ua rau mob paj hlwb, tingling, thiab loog loog, feem ntau pom nyob rau hauv cov neeg mob metabolic.[1].
Daim ntawv thov
1 Khoom noj khoom haus
MK-7 hmoov yog dav siv nyob rau hauv multivitamins, standalone K2 tshuaj ntxiv (ib txwm koob tshuaj txhua hnub: 45–360 µg), K2+D3 ua ke qauv, kua softgels, ntsiav tshuaj, tsiav tshuaj, sublingual sprays, thiab gummies. MK-7 yog daim ntawv nyiam vim tias nws lub neej ntev ib nrab (kwv yees li 3 hnub) tso cai rau noj ib hnub ib zaug.
2 Khoom noj khoom haus & dej haus ua haujlwm
Feem ntau tiv thaiv cov mis nyuj uas muaj cov nroj tsuag, cov zaub mov noj tshais, cov khoom noj khoom haus, cov hmoov protein, cov khoom noj siv mis, cov dej haus npaj txhij, thiab cov zaub mov ua haujlwm. Microencapsulated MK-7 feem ntau yog siv los tiv thaiv kev ruaj ntseg thaum ua tiav thiab txuas lub neej txee.
3 Pharmaceutical Formulations
Siv raws li API nyob rau hauv cov koob tshuaj K2 koob tshuaj rau pob txha noj qab haus huv, kev sib xyaw D3+K2 cov khoom lag luam rau pob txha, thiab cov qauv tshuaj rau cov mob tshwj xeeb.
4 Me Nyuam Me Nyuam Cov Qauv & Cov Khoom Noj Me Nyuam Me
MK-7 yog ib txwm muaj nyob rau hauv cov mis nyuj thiab yog ib qho tseem ceeb rau kev loj hlob ntawm pob txha nyob rau hauv cov me nyuam mos thiab cov me nyuam. Synthetic MK-7 yog tam sim no tso cai rau siv nyob rau hauv cov me nyuam mos mis nyob rau hauv ntau lub khw.
5 Tsiaj Khoom Noj & Tsiaj Khoom Noj
Ntxiv rau cov tsiaj nyeg, nqaij qaib, thiab aquaculture pub rau cov pob txha noj qab haus huv thiab calcium metabolism. Kuj tseem siv tau rau hauv cov qauv tsiaj laus laus thiab cov khoom noj cog qoob loo.
6 Tshuaj pleev ib ce & Kev Kho Tus Kheej
MK-7 qee zaus siv rau hauv cov tshuaj tiv thaiv kev laus, tshuaj pleev qhov muag (los pab txo cov voj voog tsaus), thiab cov tshuaj pleev xim rau daim tawv nqaij rau nws cov khoom antioxidant.
Cov lus nug nquag nug (FAQ)
Q: Vim li cas MK-7 nyiam dua lwm hom vitamin K2?
A: MK-7 muaj cov saw ntev ntev (xya lub isoprene units), uas muab nws ib nrab-lub neej ntawm li 3 hnub hauv cov ntshav. Qhov no txhais tau hais tias ib koob tshuaj ib hnub twg txaus los tswj kev ua kom tsis tu ncua ntawm osteocalcin thiab MGP txhua hnub. Shorter-chain menaquinones (xws li MK-4) muaj luv luv ib nrab-lub neej thiab xav tau ntau npaum li cas txhua hnub. MK-7 kuj yog daim ntawv tshawb fawb tshaj plaws rau cov pob txha thiab cov hlab plawv[1].
Q: Vim li cas "tag nrho-trans" purity tseem ceeb?
A: Tag nrho-trans configuration yog ib txwm tshwm sim, biologically active daim ntawv ntawm MK-7. Nws yog tib qho isomer uas tuaj yeem khi kom zoo thiab qhib cov enzyme carboxylase uas hloov mus rau osteocalcin thiab MGP. Cis-isomers (tsis yog-natural configurations) tsis paub los yog txo kev ua haujlwm hauv lub cev. Cov khoom lag luam zoo MK-7 yuav tsum tau sau tias "tag nrho-trans"[2].
Q: Puas yog MK-7 haum rau vegan thiab Halal formulations?
A: Yog. Peb MK-7 yog tsim los ntawm cov kab mob ntuj fermentation siv Bacillus subtilis ntawm cov nroj tsuag raws li substrates. Tsis siv cov khoom xyaw tsiaj los ntawm cov tsiaj. Halal, Kosher, thiab Vegan ntawv pov thawj muaj nyob rau ntawm kev thov.
Q: Puas yog MK-7 muaj kev nyab xeeb los noj nrog cov ntshav thinners (anticoagulants)?
A: Vitamin K yog qhov tseem ceeb rau kev ua kom cov ntshav txhaws ntau. Cov neeg mob noj cov tshuaj tiv thaiv qhov ncauj xws li warfarin (Coumadin) yuav tsum tsis txhob noj cov tshuaj vitamin K2 yam tsis tau sab laj nrog lawv tus kws kho mob ua ntej, vim tias vitamin K tuaj yeem cuam tshuam rau cov tshuaj ua haujlwm.
Q: Yuav ua li cas ruaj khov MK-7 hauv cov khoom tiav?
A: MK-7 rhiab heev rau lub teeb, huab cua (oxygen), cua sov, thiab noo noo. Txhawm rau kom muaj kev ruaj ntseg zoo tshaj plaws: siv lub ntim ntim UV-thaiv (cov iav amber iav, cov hnab ntawv ci), ntxiv cov tshuaj antioxidants (tocopherols), khaws cia ntawm 2-8 degree, tsis txhob muaj cua sov thiab shear processing, thiab xav txog microencapsulation. Tsim kom raug, MK-7 khaws cia muaj zog rau 24-48 lub hlis.
Q: Cov kev xaiv ntim khoom twg muaj?
A: Aluminium ntawv ci hnab (1-5 kg, inert gas-flushed), kaw yas nruas (10-25 kg), fiber nruas (25-50 kg), thiab customized ntim.
Q: Kuv puas tuaj yeem tau txais ib qho qauv ua ntej kev txiav txim ntau?
A: Yog. Cov qauv kuaj ntsuas (5-50g) yog muaj rau kev tsim kho thiab kev kuaj kom zoo. Cov qauv xa tuaj hauv 3-5 hnub ua haujlwm.
Vim li cas thiaj xaiv peb?
Koj tus kws tshaj lij kev tsim khoom & Sourcing tus khub
Peb yog ntau tshaj li tus neeg xa khoom - peb yog cov khoom lag luam sib txuas sib txuas rau siab - cov khoom xyaw zoo, cov qauv kev cai, thiab cov khoom tiav thoob plaws ntau qhov kev lag luam.
Cov kws tshaj lij
Nrog rau ntau xyoo ntawm kev paub hauv cov nroj tsuag extracts, khoom noj khoom haus additives, cosmetic raw cov ntaub ntawv, thiab cov khoom noj khoom haus, peb pab neeg coj cov kev txawj ntse txawj ntse thiab kev ua lag luam kev pom zoo rau txhua qhov kev koom tes.
01
Ntau Yam Khoom Muag
Peb muab ntau yam khoom lag luam, suav nrog cov khoom noj khoom haus ntxiv, cov nroj tsuag rho tawm, txiv hmab txiv ntoo & zaub hmoov, cov khoom siv tshuaj pleev ib ce, thiab cov khoom xyaw ua zaub mov.
02
Ib -Stop Shop
Raw Khoom:High -cov khoom xyaw purity rau zaub mov, dej haus, ntxiv, thiab kev siv tshuaj pleev ib ce.
Cov khoom tiav:Hauv -tsev tsim cov tshuaj ntsiav, mos gels, gummies, kua tee, thiab hmoov sib tov.
03
Kev pabcuam OEM / ODM / OBM
Label Design & Ntim:Custom branding tailored rau koj lub hom phiaj kev lag luam.
Formulation & R & D:Cov kws tshaj lij kev txhawb nqa los tsim cov kev cai sib xyaw, cov qauv tsim muaj, thiab cov khoom tsim tshiab.
Ntiaj teb no Logistics:Txhim khu kev xa khoom, cov ntaub ntawv, thiab kev pabcuam kev lis kev cai.
04
Quality Assurance
Kev nruj nruj raws li GMP cov qauv thiab tag nrho cov kev cai pob tshab. Peb nyob twj ywm tam sim no nrog cov kev cai thoob ntiaj teb, suav nrog FDA GRAS, EFSA, thiab lwm yam kev cai hauv cheeb tsam, kom ntseeg tau tias koj cov khoom ua tau raws li qhov kev nyab xeeb siab tshaj plaws thiab ua raws li cov qauv.
05
Ua tam sim no
Npaj los tsim nrog hwmVitamin K2 (MK-7) hmoov?
Kev txiav txim ntau & Daim ntawv cog lus Manufacturing: Nug txog cov nqi luv nqi, daim ntawv cog lus mus sij hawm ntev, thiab kev tsim khoom ntiag tug.
Thov hu rau peb ntawmella.zhang@huilinbio-tech.com.
Cov ntaub ntawv
Cim npe nrov: vitamin k2 (mk-7) hmoov (menaquinone-7), Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, ntuj, zoo, Tshuag, kev muag
