Nyob rau hauv lub ntiaj teb ntawm kev kho mob plab zom mov, ob peb lub npe tau dhau los ua li Linzess. Tab sis dab tsi yog zaj dab neeg tom qab no cov tshuaj noj muaj ntau yam dav? Cov blog no yuav muab cov khoom siv sib txawv ntawm linaclotide - cov khoom siv nquag hauv Linzess - tshawb txog nws cov kev txiav txim, thiab kev txiav txim siab muaj kev nyab xeeb thiab kev nyab xeeb kev nyab xeeb. Txawm koj yog tus neeg mob nrhiav cov ntaub ntawv lossis aB2B Buyernyob rau hauvKws Tshuaj Txhuam Tuavnrhiav kev vam meejTus muab khoom AP, Cov lus qhia no yuav xa cov ntsiab lus tseem ceeb koj xav tau.
Linaclivotide thiab linzess: to taub qhov txawv
Ua ntej, wb tau qhia meej lub homphinology, uas yog qhov tseem ceeb rau ob tus neeg siv khoom thiab cov kws tshawb fawb kev lag luam.
- Linaclotride:Nov yog lub npe generic rau covMuaj cov khoom noj muaj (API)Cov. Nws yog cov khoom siv hluavtaws uas ua raws li Guanallate Cyclase - c (gc- c)} agonist. HauvB2B Kev Lag Luam, cov tuam txhabLinaclotride APIlos ntawm cov tuam ntxhab rau kev tsim cov khoom ua tiav cov ntaub ntawv.
- Li li lipzess®:Nov yog lub npe lag luam rau cov tshuaj noj uas muaj cov ntaub pua rooj uas muaj linacloide li nws cov nquag tiv thaiv. Nws yog cov khoom ntawm abbvie thiab cov kws tshuaj kabmob kasmie.
Hauv cov ntsiab lus yooj yim: linacloutide yog cov tshuaj lom neeg cov tshuaj, thaum linzess®Puas yog cov khoom lag luam muag tshuaj uas muaj cov tshuaj no.RauCov Neeg Koom Tes Nrog, kom muaj kev muab lub siab - purity,GMP - Tau muab ntawv pov thawjyog qhov tseem ceeb.
Linzess siv rau dab tsi?
Nkag siab cov kev pom zoo yog qhov tseem ceeb. Linozess feem ntau yog siv rau kev kho mob ntawm kev ua haujlwm ntawm cov quav tsis sib haum xeeb. Raws li FDA - Daim Ntawv Pom Zoo Tso Cai[1]:
- Chim siab plob nrog cem quav (IBS - c):Rau cov neeg laus, Linzess yog qhia los daws qhov mob plab thiab txhim kho rab phom plab.
- Mob Ntev Iongopathic cem ncauj (CIC):Rau cov neeg laus, nws yog siv los ua kom cov kav khib nyiab mus.
Cov lus nug uas nquag peb ntsib yog,"Yuav siv linzess rau qhov hnyav poob?"Nws yog qhov tseem ceeb rau lub xeev uasLinzess tsis tau pom zoo rau kev poob phausCov. Nws lub tshuab cuam tshuam rau cov plab zom mov rau hauv zos thiab tsis yog qhov hnyav hnyav-}} poob tus neeg sawv cev. Siv nws rau lub hom phiaj tsis tsim nyog tuaj yeem ua rau muaj kev phom sij thiab yuav tsumZam Txim.
Linzess ua haujlwm li cas? Kev tshawb fawb tom qab kev nyem
Cov lus teb rau"Linzess ua haujlwm li cas?"lus dag hauv nws lub hom phiaj ua haujlwm. Linacloide ua haujlwm hauv zos hauv txoj hnyuv. Nws khi rau thiab ua kom cov guanlate cyclase - c (gc- c) receptors ntawm cov npoo ntawm lub plab hnyuv ob sab. Qhov kev ua tau zoo no ua rau muaj kev nce ntxiv hauv cancot guanosine monoposphaate (CGMP), uas muaj ob theem tseem ceeb[2]:
- Nws txhawb nqa lub zais ntawm chloride thiab bicarbonate rau hauv txoj hnyuv, kos duab dej rau hauv lumen thiab muag cov quav.
- Nws txo cov haujlwm ntawm kev mob ntawm kev mob -}}}}}}}}}}}}}}} Txoj kev mob plab uas cuam tshuam nrog IBS- c.
Qhov kev txiav txim siab no ntxiv ntawm ob qhocem quav thiab mob mob.
Noj tshuaj thiab sijhawm: Yuav ua li cas xav tau
Cov neeg mob ib txwm xav paub,"Ntev npaum li cas li Linzess coj mus ua haujlwm?"thiab"Linzess ceev npaum li cas?"
Pib ntawm kev txiav txim:Thaum qee tus neeg mob yuav muaj kev sib tw tso quav tsis pub dhau ob peb koob tshuaj, chaw kuaj mob ntsuas ntsuas ntau lub lim tiam ntawm kev kho mob. Cov ntaub ntawv qhia txog cov ntaub ntawv uas qhia tias cov neeg mob tuaj yeem cia siab pom kev txhim kho lawv cov tsos mob nyob rau hauv thawj lub lis piam [1].
Yuav ua li cas coj Linzess:Cov tshuaj noj yog noj ib leeg, ib hnub txhua hnub ntawm lub plab khoob, tsawg kawg 30 feeb ua ntej thawj pluas noj hnub. Qhov no yog qhov tseem ceeb rau kev ua tau zoo thiab txo cov kev mob tshwm sim tsawg.
Dab tsi yog qhov muaj zog ntawm linzess?Rau cov IBS - c, cov koob tshuaj pom zoo yog 290 mcg ib zaug txhua hnub. Rau CIC, cov koob tshuaj pom zoo yog 145 mcg ib zaug txhua hnub. Ib qho koob tshuaj 72 MCG tseem muaj rau CIC, tab sis 290 koob tshuaj yog lub zog tshaj plaws muaj zog.
Vim li cas thiaj li linzess txaus ntshai? Nkag siab txog cov kev pheej hmoo thiab cov kev mob tshwm sim
Cov lus nug"Vim li cas Linzess puas txaus ntshai?"Feem ntau cov qog ntawm kev txhawj xeeb txog nws cov kev mob tshwm sim. Thaum Lrzess yog fda {{1} Kuv pom zoo thiab siv tshuaj kho kom raug, nws nqa cov kev pheej hmoo.
Feem ntau cov khoom siv sab ntau tshaj plaws yograws plab, uas qee zaum tuaj yeem qee zaum hnyav. Hauv kev sim tshuaj sim, raws plab tau tshaj tawm hauv 2% ntawm cov neeg mob[1]Cov. Qhov no yog vim li cas nws yogtsis sib haum(yuav tsum tsis txhob siv) hauv:
- Cov neeg mob pediaric nyob rau hnub nyoog 6 xyoos.
- Cov neeg mob uas muaj lub ntsej muag lossis cov neeg siv dag zog thev naus laus zis.
Kev phom sij tshwm sim los ntawm lub cev qhuav dej hnyav vim yog raws plab, tshwj xeeb tshaj yog nyob rau hauv cov neeg muaj zog.Rau B2B cov neeg yuav khoom thiab cov neeg xa khoom, hais txog cov lus ceeb toom kev nyab xeeb hauv cov ntaub ntawv khoom lag luam yog lub luag haujlwm tseem ceeb.
Tag
Linzess (linaclode) yog lub pob zeb kho rau IBS - c thiab cic, muab kev pab cuam los ntawm kev tshwj xeeb, kev sib cav. Rau cov neeg mob, nkag siab tias nws siv tau zoo, sijhawm, thiab cov kev mob tshwm sim yog qhov tseem ceeb rau kev nyab xeeb thiab siv tau zoo. RauKws tsim tshuaj thiab cov khoom xa tuaj, Linaclotridesawv cev rau ib qho tseem ceebkev caij lag luamHauv GI yeeb tshuaj ua lag luam, tas txhim khu kev qha kom ntseeg tau ntawm qhov siab -}} zooCov khoom xyaw nquagthiab nruj me ntsis rauNtiaj teb kev cai tswj kev ua raws.
Rau kev lag luam nrhiav tus khub uas ntseeg siab rau cov khoom siv raw, thov hu rau peb kom paub txog peb cov ntaub ntawv sau txog peb cov ntaub ntawv sau txog peb cov ntaub ntawv ntawm GMP {{}} Daim ntawv lees paub APIS.
Ntawv Sawv cev
[1] Linzess (LATBACLOTIVIDE) [Cov Ntaub Ntawv Sau Npe]. (2023). Abbvie Inc. Rov Los Los Ntawmhttps://www.rxabbvie.com/pdf/linzess_pi.pdf
[2] RAO, SS, & Quigley, em (2014). LinacLotide: Kev kho tshiab rau kev mob tshiab rau kev mob cuav thiab chim siab plob tsis huv syndrome.Phau ntawv Journal ntawm cov chaw kuaj mob pa roj, 48(1), 13–18.
Tsis paub tseeb:Cov blog no yog rau cov ntaub ntawv qhia xwb thiab tsuas yog ua tsis tau kev kho mob xwb. Cov neeg mob yuav tsum tau sab laj tus kws tshaj lij kev kho mob ua ntej pib lossis hloov pauv txhua yam kev kho mob. Linzess yog tshuaj noj. Rau cov lag luam, txhua yam haujlwm cuam tshuam nrog cov khoom xyaw hauv zos thiab thoob ntiaj teb thiab cov cai.